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List of works by Francisco Ciruela

A modification of the split-tobacco etch virus method for monitoring interactions between membrane proteins in mammalian cells.

scientific article published on 31 January 2012

A new interpretative paradigm for Conformational Protein Diseases.

scientific article published on March 2013

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R.

scientific article

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

scientific article

Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor

scientific article

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.

scientific article published on 31 December 2014

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease

scientific article published on 22 November 2017

Adenosine A1-A2A Receptor-Receptor Interaction: Contribution to Guanosine-Mediated Effects

scientific article published on 13 December 2019

Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain

scientific article

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent

scientific article published on 9 April 2015

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

scientific article

Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment

scientific article published on 04 January 2019

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics.

scientific article

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on 21 August 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

scientific article published on July 2004

Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes

Adenosine Receptors ⬇️

scientific article published on 01 May 2011

Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain.

scientific article published on 18 February 2011

Adenosine receptor heteromers and their integrative role in striatal function

scientific article

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation

scientific article published in November 2004

Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling

scientific article published on 31 October 2009

Adenosine-glutamate receptor-receptor interactions in the central nervous system

Adenosine/dopamine receptor-receptor interactions in the central nervous system

scholarly article by Rafael Franco et al published January 2001 in Drug Development Research

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family.

scientific article

Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands.

scientific article published on 5 July 2011

An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors

scientific article published in October 2010

An update on adenosine A2A receptors as drug target in Parkinson's disease

scientific article published on September 2011

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia

scientific article

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

scientific article published on 4 October 2017

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression

scientific article published on 5 August 2017

Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers

scientific article

Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors.

scientific article published on October 2010

Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners

scientific article

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization

scientific article published on 12 May 2017

Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD)

scientific article published on 06 March 2011

Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.

scientific article published on 24 January 2017

Cell Membrane Composition Affects GPCR Aggregation

article

Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum

scientific article published on 6 December 2007

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6

scientific article published on 24 July 2020

Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices

scientific article published on 30 October 2010

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

scientific article published on 28 January 2019

Coassembly and coupling of SK2 channels and mGlu5 receptors.

scientific article

Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A2A receptors in mice.

scientific article published on 24 August 2017

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

scientific article published on September 2004

Control of glutamate release by complexes of adenosine and cannabinoid receptors

scientific article published on 23 January 2020

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article

Deciphering G protein-coupled receptor biology with fluorescence-based methods

scientific article published on January 2014

Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

scientific article published on 03 October 2020

Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators

scientific article published on 27 March 2020

Detection of heteromerization of more than two proteins by sequential BRET-FRET

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

scientific article

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

scientific article

Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique

scientific article

Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

scientific article published on 25 November 2017

Dimer-based model for heptaspanning membrane receptors

scientific article published on 01 July 2005

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

scientific article published on 10 October 2020

Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation.

scientific article

Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.

scientific article published on 23 April 2013

Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers.

scientific article published on October 2010

Dopamine D4 receptor oligomerization--contribution to receptor biogenesis

scientific article

Dopamine receptor heteromers: biasing antipsychotics

Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal dopamine D<sub>2</sub>- muscarinic acetylcholine M<sub>1</sub> receptor heteromer

scientific article published on 01 July 2021

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

scientific article published on 19 September 2017

Ecto-adenosine deaminase: An ecto-enzyme and a costimulatory protein acting on a variety of cell surface receptors

Editorial: Purinergic Pharmacology

scholarly article by Francisco Ciruela & Kenneth A Jacobson published 2019 in Frontiers in Pharmacology

Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine- Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors

scientific article published on 01 January 2018

Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.

scientific article published on 6 May 2015

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

scientific article published on 9 April 2018

Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits

scientific article published on 16 September 2010

Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system

scientific journal article

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor

scientific article published on 17 January 2017

Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks.

scientific article published on 4 June 2012

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells

scientific article published on 3 December 2015

Fentanyl–trazodone–paracetamol triple drug combination: Multimodal analgesia in a mouse model of visceral pain ⬇️

scientific article published on February 4, 2011

Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity

scientific article

Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface

scientific article published on 06 June 2012

Fluorescence-based methods in the study of protein-protein interactions in living cells

scientific article published on 16 July 2008

Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers

scientific article published on 17 September 2019

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct

scientific article published on 14 August 2018

Functional relevance of neurotransmitter receptor heteromers in the central nervous system.

scientific article published on 10 August 2007

G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum

scientific article published on 01 November 2019

G protein-coupled receptor heterodimerization in the brain

scientific article published in January 2013

G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission.

scientific article published on 07 May 2012

G protein-coupled receptor oligomerization for what?

scientific article published on 01 October 2010

G protein-coupled receptors interacting proteins: towards the druggable interactome

scientific article published on 01 January 2012

G-protein-coupled receptor heteromer dynamics.

scientific article

GABAB Receptors-Associated Proteins: Potential Drug Targets in Neurological Disorders? ⬇️

scientific article published on January 1, 2012

GPCR oligomerization analysis by means of BRET and dFRAP.

scientific article published in January 2015

Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice

scientific article

Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

scientific article published on 01 November 2006

Glutamate mGlu5-Adenosine A2A-Dopamine D2 Receptor Interactions in the Striatum. Implications for Drug Therapy in Neuro-psychiatric Disorders and Drug Abuse

scholarly article published 1 March 2003

Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation

scientific article

Guanosine behind the scene.

scientific article published in July 2013

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors

scientific article published on 05 December 2020

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

scientific article

Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release.

scientific article published on 17 May 2006

Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.

scientific article published on 2 May 2010

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on February 2004

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

scientific article published on 19 December 2016

Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop

scientific article published on 23 March 2010

Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-<i>In Vitro</i> and <i>In Vivo</i> Investigations

scientific article published on 26 November 2020

Inhibitory Control of Basolateral Amygdalar Transmission to the Prefrontal Cortex by Local Corticotrophin Type 2 Receptor

scientific article published on 01 February 2020

Introductory and Basic aspects

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes

scientific article

Kainic acid-induced status epilepticus decreases mGlu5 receptor and phase-specifically downregulates Homer1b/c expression

scientific article published on 28 December 2019

L-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy

scientific article published on 18 June 2019

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism

scientific article published on 15 September 2020

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

scientific article published on April 2003

Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization

scientific article published on January 2008

Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.

scientific article

Lighting up multiprotein complexes: lessons from GPCR oligomerization

scientific article

Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors

scientific article

Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions

scientific article published in August 2003

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

scientific article published on 01 October 2018

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells

scientific article published on 30 March 2009

Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.

scientific article

Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts

scientific article published on 30 May 2011

Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration.

scientific article

Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field

scientific article published on 06 September 2013

Muscarinic receptor family interacting proteins: role in receptor function.

scientific article published on 4 December 2010

Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity

scientific article published on October 2004

Neuromodulatory Effects of Guanine-Based Purines in Health and Disease

article

Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

scientific article

New ionic targets of 3,3',5'-triiodothyronine at the plasma membrane of rat Sertoli cells

scientific article published on 09 January 2019

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

scientific article published on 14 June 2007

Oligomerization of G protein-coupled receptors: Still doubted?

scientific article published on 12 December 2019

On the existence and function of galanin receptor heteromers in the central nervous system

scientific article published on 26 October 2012

On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.

scientific article published on 20 January 2011

On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.

scientific article published on October 2010

On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons

scientific article published on February 2012

Optical Modulation of Metabotropic Glutamate Receptor Type 5 In Vivo Using a Photoactive Drug

scientific article published on 01 January 2019

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article published on 11 April 2017

PBF509, an Adenosine A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

scholarly article by Fabiana Núñez et al published 2018 in Frontiers in Pharmacology

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

scientific article published on 19 December 2016

Partners for adenosine A1 receptors

scientific article

Pharmacological activation of mGlu5 receptors with the positive allosteric modulator, VU0360172 modulates thalamic GABAergic transmission

scientific article published on 05 August 2020

Pharmacology

scholarly article

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome.

scientific article

Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand

scientific article

Plasma membrane diffusion of G protein-coupled receptor oligomers

scientific article published on 21 July 2008

Portraying G protein-coupled receptors with fluorescent ligands

scientific article

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

scientific article

Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor

scientific article published on 20 December 2013

Preface

Preface. In cells

scientific article published in January 2013

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

scientific article published on 19 January 2016

Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum

scientific article published in 2022

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

scientific article

Pridopidine Reverses Phencyclidine-Induced Memory Impairment

scientific article

Proximity Ligation Assay Image Analysis Protocol: Addressing Receptor-Receptor Interactions

scientific article published on 01 January 2019

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels

scientific article

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

scientific article published on 01 May 2003

Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist

scientific article published on 31 May 2018

Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement

scientific article

Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

scientific article published on 23 July 2019

Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.

scientific article

Role of electrostatic interaction in receptor-receptor heteromerization

scientific article published in January 2005

SK2 Channels Associate With mGlu Receptors and Ca2.1 Channels in Purkinje Cells

scientific article published on 19 September 2018

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

scientific article published on 19 January 2017

Special Issue: Adenosine Receptors.

scientific article

Special Issue: G Protein-Coupled Adenosine Receptors: Molecular Aspects and Beyond

scientific article published on 15 March 2020

Striatal Dopamine D2-Muscarinic Acetylcholine M1 Receptor-Receptor Interaction in a Model of Movement Disorders

scientific article published on 13 March 2020

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

scientific journal article

Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation

scientific article

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

scientific article published on 22 June 2009

Synergistic Interaction Between Fentanyl and a Tramadol:Paracetamol Combination on the Inhibition of Nociception in Mice

scientific article published on February 3, 2012

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

scientific article

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

scientific article

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

scientific article published on 15 March 2017

The ADORA1 mutation linked to early-onset Parkinson’s disease alters adenosine A1-A2A receptor heteromer formation and function

scientific article published in 2022

The Exonuclease Trex2 Shapes Psoriatic Phenotype

scientific article published on 27 June 2016

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation

scientific article

The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization

scientific article published on 14 April 2010

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

scientific article published on 25 August 2017

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

scientific article published on 3 March 2013

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin

scientific journal article

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

scientific article

The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions

scientific article published on October 2010

The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration

scientific article published on 18 October 2007

The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity

scientific journal article

The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals

scientific article

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor

scientific article

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

scientific article published on 21 April 2015

The two-state dimer receptor model: a general model for receptor dimers

scientific article published on 24 February 2006

The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells

scientific article

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression

scientific article published on 7 August 2012

Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism

scientific article published on 28 August 2018

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism

scientific article

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats

scientific article

Visualizing G Protein-Coupled Receptor-Receptor Interactions in Brain Using Proximity Ligation In Situ Assay

scientific article

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

scientific article published on 7 July 2006

β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.

scientific article published on 13 September 2013

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