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List of works by Damian J Krysan

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

scientific article published on 31 July 2018

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

scientific article published on 22 June 2015

A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis ⬇️

scientific article published on April 1, 2011

A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis.

scientific article published on 27 May 2010

A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms ⬇️

scientific article published on June 15, 2011

Adenylate Kinase Release as a High-Throughput-Screening-Compatible Reporter of Bacterial Lysis for Identification of Antibacterial Agents ⬇️

scientific article published on October 1, 2012

Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children.

scientific article published in March 2011

Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.

scientific article

Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization

scientific article published on June 2009

Antifungal drug development: challenges, unmet clinical needs, and new approaches.

scientific article published on May 2014

Antifungal drug discovery: something old and something new

scientific article

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase

scientific article

Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans

scientific article published on 26 February 2020

Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo

scientific article

Candida albicans morphogenesis is not required for macrophage interleukin 1β production.

scientific article

Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.

scientific article published on 27 December 2013

Candida auris: The Canary in the Mine of Antifungal Drug Resistance

scientific article published on 01 August 2019

Candida-streptococcal interactions in biofilm-associated oral diseases

scientific article published on 13 December 2018

Catching fire: Candida albicans, macrophages, and pyroptosis

scientific article

Challenges in the development of novel anticryptococcal agents

scientific article published on 3 August 2016

Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans

scientific article

Cryptococcus neoformans Phosphoinositide-Dependent Kinase 1 (PDK1) Ortholog Is Required for Stress Tolerance and Survival in Murine Phagocytes ⬇️

scientific article published on October 19, 2012

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

scientific article published on 26 September 2019

Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis

scientific article

Enantioselective Synthesis of (+)-Hippolide J and Reevaluation of Antifungal Activity

scientific article published on 24 September 2020

Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

scientific article

Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae

scientific article

Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency.

scientific article published on 09 August 2017

High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

scientific article published on 6 November 2015

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

article

Human Tooth as a Fungal Niche: Candida albicans Traits in Dental Plaque Isolates

scientific article published in 2023

Identification, in Vitro Activity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules ⬇️

scientific article published on February 22, 2011

Live Candida albicans suppresses production of reactive oxygen species in phagocytes

scientific article

Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel derivatives as homoenolate equivalents ⬇️

scientific article published on 01 August 1988

Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides

scientific article published on 01 August 1999

Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

scientific article published on 18 December 2018

Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

scientific article

Serum procalcitonin levels aid in distinguishing bacterial from aseptic meningitis in children

scientific article published on 01 May 2009

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

scientific article

Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen ⬇️

scientific article published on 27 May 2015

Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo.

scientific article published on 24 February 2014

Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2

scientific article published on 01 May 2000

Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes

scientific article published on 22 February 2018

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

scientific article published on 11 September 2017

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis

scientific article

The RAM network in pathogenic fungi.

scientific article

The unmet clinical need of novel antifungal drugs

scientific article published on 17 January 2017

Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs.

scientific article

Transcription factor network efficiency in the regulation of Candida albicans biofilms: it is a small world

scientific article published on 9 January 2018

Treatment with oseltamivir decreases the length of hospital stay in critically ill children with influenza

scientific article published on 01 March 2012

Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1.

scientific article

Voriconazole Therapeutic Drug Monitoring

scientific article published on 30 March 2014

Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.

scientific article

Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment

scientific article

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