List of works - Anna Waszkielewicz

Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains

scientific article published on 13 February 2018

Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239.

scientific article published on 27 October 2017

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.

scientific article published on 2 November 2015

Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives

scientific article published on 07 June 2020

Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone.

scientific article

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

scientific article

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

scientific article

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

scientific article published on 29 November 2015

Antimutagenic compounds and their possible mechanisms of action

scientific article published on 11 March 2014

Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin

scientific article published on 13 April 2019

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

scientific article published on 3 August 2016

Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders--A Review of Structure-Activity Relationships

scientific article published on 17 June 2015

Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone

scientific article

Correction: Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

scientific article published in 2018

Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols

scientific article published on 17 May 2022

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents

scientific article published on 03 March 2016

Design, synthesis and activity against Staphylococcus epidermidis of 5-chloro-2- or 5-chloro-4-methyl-9H-xanthen-9-one and some of its derivatives

scientific article published on 08 October 2020

Design, synthesis and anticonvulsant-analgesic activity of new -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols

scientific article published on 11 November 2016

Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone

scientific article published on 18 April 2018

Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system

scientific article published on 09 September 2019

Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties.

scientific article published on 28 September 2016

Effect of Vita Glucan on some antioxidant parameters of the human blood. In vitro study

scientific article published in November 2006

Effect of some newly synthesized xanthone and piperazine derivatives with cardiovascular activity on rheology of human erythrocytes in vitro.

scientific article published on 16 August 2016

Evaluation of anticonvulsants for possible use in neuropathic pain.

scientific article published on January 2011

Four N-(E)-cinnamoyl (cinnamamide) derivatives of aminoalkanols with promising anticonvulsant and analgesic activity

scientific article published on 04 April 2019

Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system.

scientific article

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats

scientific article

HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice.

scientific article

HBK-14 and HBK-15, triple 5-HT 1A , 5-HT 7 and 5-HT 3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

scientific article published on 17 July 2017

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

scientific article published on 22 June 2017

HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

scientific article published on 16 October 2018

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

scientific article published on 27 April 2016

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.

scientific article published on 24 July 2016

Influence of protonation on the geometry of 2-{[(2,6-dimethylphenoxy)ethyl]amino}-1-phenylethan-1-ol: crystal structures of the free base and of its chloride and 3-hydroxybenzoate salt forms

scientific article published in January 2022

Influence of the position of the methyl substituent and N-oxide formation on the geometry and intermolecular interactions of 1-(phenoxyethyl)piperidin-4-ol derivatives

scientific article published on 01 January 2020

Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline α1-adrenoceptor antagonists.

scientific article

Ion channels as drug targets in central nervous system disorders

scientific article

KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

scientific article published on 04 September 2020

Kolagen – struktura oraz zastosowanie w kosmetologii i medycynie estetycznej

scientific article published in 2012

MH-76, a Novel Non-Quinazoline α-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats

scientific article published on 18 May 2021

N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties.

scientific article published on 27 June 2015

Novel Xanthone Derivatives Impair Growth and Invasiveness of Colon Cancer Cells In Vitro

scientific article published on 7 October 2021

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

scientific article

Physicochemical and biological evaluation of a cinnamamide derivative R,S-(2E)-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders.

scientific article

Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives

scientific article published in January 2012

Preliminary antifungal activity assay of selected chlorine-containing derivatives of xanthone and phenoxyethyl amines

scientific article published on 04 July 2018

Preliminary assessment of mutagenic and anti-mutagenic potential of some aminoalkanolic derivatives of xanthone by use of the Vibrio harveyi assay

scientific article published on 24 April 2014

Preliminary evaluation of anticonvulsant activity of some aroxyacetamides and aroxyethylamines.

scientific article published in September 2005

Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives

scientific article published in January 2006

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties – design, synthesis and pharmacological evaluation

scientific article published on 17 June 2022

Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist

scientific article published on 12 March 2019

Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands

scientific article

Short Commentary on Current Trends in Medicinal Chemistry of the Central Nervous System

scientific article published in 2014

Simultaneous LC/ESI-MS separation method for the enantioseparation of some new anticonvulsant drugs

scientific article published on 30 January 2014

Single Administration of HBK-15-a Triple 5-HT1A, 5-HT7, and 5-HT3 Receptor Antagonist-Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

scientific article published on 26 May 2017

Sirtuins as a potential molecular target of cosmetic ingredients

scientific article published on 25 March 2022

Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals

scientific article published on 09 April 2015

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

scientific article published on 11 November 2016

Supramolecular architectures of succinates of 1-hydroxypropan-2-aminium derivatives

scientific article published on 19 June 2018

Synthesis and Anticonvulsant Activity of N-(trans)- 3-phenylprop-2-en-1-yl (Cinnamyl) Derivatives of Aminoalkanols

scientific article published on 8 August 2014

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl)Piperazine Derivatives

scientific article published on 14 August 2014

Synthesis and activity of di- or trisubstituted N -(phenoxyalkyl)- or N -{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

scientific article published on 25 April 2018

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems

scientific article published on 15 September 2016

Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

scientific article published on 19 October 2018

Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs

scientific article published on 14 September 2011

Synthesis and antimycobacterial assay of some xanthone derivatives

scientific article published in January 2008

Synthesis and evaluation of anticonvulsant activity of N-(2,5-dimethylphenoxy)- and N-[(2,3,5-trimethylphenoxy)alkyl]aminoalkanols

scientific article published in January 2015

Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.

scientific article

Synthesis and in vitro Evaluation of the Anticancer Potential of New Aminoalkanol Derivatives of Xanthone

scientific article published on 4 April 2016

Synthesis and preliminary evaluation of anticonvulsant activity of some [4-(benzyloxy) benzoyl]- and [4-(benzyloxy) benzyl] aminoalkanol derivatives

scientific article published on 01 March 2007

Synthesis of N ‐(phenoxyalkyl)‐, N ‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N ‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System

scientific article published on 27 August 2019

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice.

scientific article published on May 2016

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation

scientific article published on 22 July 2015

The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments

scientific article published on 27 June 2020

The nitric oxide/soluble cyclic guanylase/cyclic guanosine monophosphate pathway is involved in the cardiovascular effects of a novel α1- and β-adrenoceptor antagonist

scientific article published on 17 December 2014

The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity.

scientific article

List of works by Anna Waszkielewicz

Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains

Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239.

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.

Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives

Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone.

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

Antimutagenic compounds and their possible mechanisms of action

Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders--A Review of Structure-Activity Relationships

Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone

Correction: Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents

Design, synthesis and activity against Staphylococcus epidermidis of 5-chloro-2- or 5-chloro-4-methyl-9H-xanthen-9-one and some of its derivatives

Design, synthesis and anticonvulsant-analgesic activity of new -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols

Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone

Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system

Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties.

Effect of Vita Glucan on some antioxidant parameters of the human blood. In vitro study

Effect of some newly synthesized xanthone and piperazine derivatives with cardiovascular activity on rheology of human erythrocytes in vitro.

Evaluation of anticonvulsants for possible use in neuropathic pain.

Four N-(E)-cinnamoyl (cinnamamide) derivatives of aminoalkanols with promising anticonvulsant and analgesic activity

Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system.

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats

HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice.

HBK-14 and HBK-15, triple 5-HT 1A , 5-HT 7 and 5-HT 3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.

Influence of protonation on the geometry of 2-{[(2,6-dimethylphenoxy)ethyl]amino}-1-phenylethan-1-ol: crystal structures of the free base and of its chloride and 3-hydroxybenzoate salt forms

Influence of the position of the methyl substituent and N-oxide formation on the geometry and intermolecular interactions of 1-(phenoxyethyl)piperidin-4-ol derivatives

Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline α1-adrenoceptor antagonists.

Ion channels as drug targets in central nervous system disorders

KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

Kolagen – struktura oraz zastosowanie w kosmetologii i medycynie estetycznej

MH-76, a Novel Non-Quinazoline α-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats

N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties.

Novel Xanthone Derivatives Impair Growth and Invasiveness of Colon Cancer Cells In Vitro

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

Physicochemical and biological evaluation of a cinnamamide derivative R,S-(2E)-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders.

Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives

Preliminary antifungal activity assay of selected chlorine-containing derivatives of xanthone and phenoxyethyl amines

Preliminary assessment of mutagenic and anti-mutagenic potential of some aminoalkanolic derivatives of xanthone by use of the Vibrio harveyi assay

Preliminary evaluation of anticonvulsant activity of some aroxyacetamides and aroxyethylamines.

Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties – design, synthesis and pharmacological evaluation

Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist

Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands

Short Commentary on Current Trends in Medicinal Chemistry of the Central Nervous System

Simultaneous LC/ESI-MS separation method for the enantioseparation of some new anticonvulsant drugs

Single Administration of HBK-15-a Triple 5-HT1A, 5-HT7, and 5-HT3 Receptor Antagonist-Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

Sirtuins as a potential molecular target of cosmetic ingredients

Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

Supramolecular architectures of succinates of 1-hydroxypropan-2-aminium derivatives

Synthesis and Anticonvulsant Activity of N-(trans)- 3-phenylprop-2-en-1-yl (Cinnamyl) Derivatives of Aminoalkanols

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl)Piperazine Derivatives

Synthesis and activity of di- or trisubstituted N -(phenoxyalkyl)- or N -{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems

Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs

Synthesis and antimycobacterial assay of some xanthone derivatives

Synthesis and evaluation of anticonvulsant activity of N-(2,5-dimethylphenoxy)- and N-[(2,3,5-trimethylphenoxy)alkyl]aminoalkanols

Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.

Synthesis and in vitro Evaluation of the Anticancer Potential of New Aminoalkanol Derivatives of Xanthone

Synthesis and preliminary evaluation of anticonvulsant activity of some [4-(benzyloxy) benzoyl]- and [4-(benzyloxy) benzyl] aminoalkanol derivatives

Synthesis of N ‐(phenoxyalkyl)‐, N ‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N ‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice.

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation

The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments

The nitric oxide/soluble cyclic guanylase/cyclic guanosine monophosphate pathway is involved in the cardiovascular effects of a novel α1- and β-adrenoceptor antagonist

The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity.