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List of works by Dermot McGovern

A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients

scientific article published on 02 July 2016

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

scientific article published on July 2016

A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals

scientific article published on 01 April 2019

A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study

scientific article published on 01 November 2018

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition

scientific article

A common CTLA4 haplotype associated with coeliac disease

scientific article published on 01 April 2005

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

scientific article

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci

scientific journal article

A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease

scientific article

A novel role for KLF14 in T regulatory cell differentiation

scientific article

A preliminary evaluation of integrated treatment for co-existing substance use and severe mental health problems: Impact on teams and service users

article

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

scientific article published on 09 August 2016

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

scientific article published on 25 April 2018

A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables

scientific article published on 15 November 2015

Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses

scientific article published on 9 May 2016

Altered intestinal ACE2 levels are associated with inflammation, severe disease and response to anti-cytokine therapy in IBD

scientific article published on 02 November 2020

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians

article

An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis

scientific article published on 01 August 2018

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

scientific article

Analysis of protein-coding genetic variation in 60,706 humans

scientific article (publication date: 17 August 2016)

Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease

scientific article published on April 2003

Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease

scientific article

Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis

scientific article published on 13 April 2016

Asians have more perianal Crohn disease and ocular manifestations compared with white Americans.

scientific article published on 18 November 2017

Assessing Health Status in Inflammatory Bowel Disease Using a Novel Single-Item Numeric Rating Scale ⬇️

scientific article published on December 19, 2012

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

article

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

scientific article published on 01 February 2019

Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico

scientific article

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease

scientific article published on 8 April 2017

Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium

scientific article published on 8 January 2016

Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease

scientific article published on 18 June 2019

Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity

scientific article published on 01 March 2002

CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway

scientific article

CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.

scientific article published in January 2018

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor

scientific article published on 10 May 2016

Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study

scientific article published on 2 November 2017

Challenges in IBD Research: Precision Medicine

scientific article published on 01 May 2019

Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda

scientific article published on March 2013

Characterization of candidate genes in inflammatory bowel disease-associated risk loci

scientific article published on 18 August 2016

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans

scientific article

Clinical and demographic characteristics predictive of treatment outcomes for certolizumab pegol in moderate to severe Crohn's disease: analyses from the 7-year PRECiSE 3 study

scientific article published on June 2015

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients

scientific article

Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.

scientific article

Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease

scientific article published on August 2010

Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease

scientific article published on August 2015

Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort

scientific article published on 24 December 2020

Common variants at five new loci associated with early-onset inflammatory bowel disease

scientific article

Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

correction of a scientific article; published on 30 May 2019

Crohn's disease: genetic susceptibility, bacteria, and innate immunity

scientific article published in The Lancet

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

scientific article

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis

scientific article

Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease

scientific article

Development of an index to define overall disease severity in IBD.

scientific article published on 25 October 2016

Disease-specific alterations in the enteric virome in inflammatory bowel disease

scientific article

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

scientific article

Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease?

scientific article published in May 2012

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

scientific article

Early remission status predicts long-term outcomes in patients with Crohn's disease treated with certolizumab pegol

scientific article published on 5 August 2016

Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study.

scientific article published on 26 October 2013

Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

scientific article published on 13 September 2016

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

Erratum: Corrigendum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

scholarly article published in Nature Genetics

Erratum: Genome-wide association identifies multiple ulcerative colitis susceptibility loci

scholarly article published in Nature Genetics

Exploring the attitudes of staff working within mental health settings toward clients who use cannabis

article

Fine mapping of theIBD1 locus did not identify Crohn disease-associatedNOD2 variants: Implications for complex disease genetics

article

Fine-mapping inflammatory bowel disease loci to single-variant resolution

scientific article

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

scientific article

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

scientific article published in January 2018

Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis

scientific article published on December 2003

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

scientific article

Genetic Analysis of Ulcerative Colitis in Japanese Individuals Using Population-specific SNP Array

scientific article published on 19 February 2020

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis

scientific article published on 01 July 2018

Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study

scientific article

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease

scientific article published on June 2009

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

scientific article published on 21 December 2012

Genetic predictors of medically refractory ulcerative colitis

scientific journal article

Genetic variants influencing susceptibility to inflammatory bowel disease and its natural history

doctoral thesis by Dermot P. B. McGovern

Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

scientific article

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

scientific article

Genetics of Inflammatory Bowel Diseases

scientific article published on 06 August 2015

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease

scientific article

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

scientific article published on 28 September 2016

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

scientific article

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

scientific article

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

scientific article published on 5 January 2018

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease

scientific article published on 07 October 2019

HLA-DQA1*05 is associated with the development of antibodies to anti-TNF therapy

article

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

scientific article

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

Host–microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal–luminal interface ⬇️

scientific article published on June 22, 2011

Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function

scientific article

Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis

scientific article published on 13 March 2020

IBD Serology and Disease Outcomes in African Americans With Crohn's Disease

scientific article published in December 2017

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein

scientific article

IL23R haplotypes provide a large population attributable risk for Crohn's disease

scientific article published on September 2008

Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans

scientific article

Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans

scientific article

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups

scientific article published on 01 August 2019

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans

scientific article

Immunochip meta-analysis of inflammatory bowel disease identifies three novel loci and four novel associations in previously reported loci.

scientific article published on 23 March 2018

Increased Prevalence of Inflammatory Bowel Disease in Patients with Mutations in Genes Encoding the Receptor Subunits for TGFβ.

scientific article published on 2 August 2016

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

scientific article (publication date: 15 May 2002)

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

scientific article

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

preprint published 25 September 2016

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

scientific article

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

scientific article

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

scientific article published on 19 March 2020

LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease ⬇️

scientific article published on March 1, 2012

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients

scientific article published on 23 March 2017

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics

scientific article published on 01 October 2018

Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation

scientific article

MAGI2 genetic variation and inflammatory bowel disease

scientific article published on January 2009

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models

scientific article published on 05 March 2019

Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study ⬇️

scientific article published on November 29, 2012

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency

scientific article published on 22 November 2016

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice.

scientific article

Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease

scientific article

Molecular classification of Crohn's disease reveals two clinically relevant subtypes.

scientific article published on 14 October 2016

Molecular patterns in human ulcerative colitis and correlation with response to infliximab

scientific article published on December 2014

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

scientific article published on 29 May 2019

Multidimensional Prognostic Risk Assessment Identifies Association Between IL12B Variation and Surgery in Crohn’s Disease ⬇️

scientific article published on July 1, 2013

Multilevel regularized regression for simultaneous taxa selection and network construction with metagenomic count data

scientific article

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

scientific article published in May 2005

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

scientific article

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

scientific article published on 27 January 2017

NK cells are biologic and biochemical targets of 6-mercaptopurine in Crohn's disease patients

scientific article published on 20 December 2016

NOD2 (CARD15), the first susceptibility gene for Crohn's disease

scientific article published on December 2001

NOD2, not yet: con

scientific article published on 01 May 2005

Nonbloody Diarrhea but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo Crohn's Disease After Ileal Pouch-anal Anastomosis for Ulcerative Colitis

scientific article published on 20 November 2015

Novel Microbial-Based Immunotherapy Approach for Crohn's Disease

scientific article published on 19 July 2019

O-004 Analysis of Chromatin and Transcriptional Profiles in Crohnʼs Disease Reveals Molecular Subclasses and Highlights Functional Regulatory Regions Implicated in Disease

Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits.

scientific article published on 8 October 2015

Outcomes with Anti-Tumour Necrosis Factor-Alpha Therapy and Serology in Patients with Denovo Crohn's Disease After Ileal Pouch Anal Anastomosis

scientific article

Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease

scientific article published on 8 October 2016

Paneth cell defects in Crohn's disease patients promote dysbiosis

scientific article published on 02 June 2016

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway

scientific article published on 02 March 2016

Personalized Medicine in Inflammatory Bowel Disease

scientific article published on October 2014

Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository

scientific article published on 09 June 2009

Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases

scientific article published on 21 May 2018

Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

scientific article published on 08 September 2020

Pre-Pouch Ileitis is Associated with Development of Crohn's Disease-Like Complications and Pouch Failure

scientific article published on 10 December 2020

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

scientific article published on 27 February 2019

Prevalence and Associations of Avascular Necrosis of the Hip in a Large Well-characterized Cohort of Patients With Inflammatory Bowel Disease

scientific article published on 01 January 2019

Prevalence and Effect of Genetic Risk of Thrombo-embolic Disease in Inflammatory Bowel Disease

scientific article published on 19 October 2020

Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study

scientific article

Recent advances in IBD pathogenesis: genetics and immunobiology

scientific article published on December 2008

Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn′s disease

scientific article published on 23 April 2020

Relationship between proximal Crohn's disease location and disease behavior and surgery: a cross-sectional study of the IBD Genetics Consortium

scientific article

Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis

scientific article published on 16 August 2017

Reply

scientific article published on 05 May 2017

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism

scientific article

Review article: the genetics of inflammatory bowel disease

scientific article

Risks and benefits of azathioprine therapy

scientific article

Role ofNOD2 variants in spondylarthritis

scientific article published on 01 June 2002

Sa1868 NK Cells Are Biologic and Biochemical Target of 6-Mercaptopurine in Crohn's Disease Patients

Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location

Service innovations

article

Should biologic agents be stopped before surgery for inflammatory bowel disease?

scientific article published on 04 November 2014

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

scientific article

Smoking status in therapeutic trials in Crohn's disease

scientific article published in July 2005

Sparse Inverse Covariance Estimation with L0 Penalty for Network Construction with Omics Data

scientific article

Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development

scientific article published on April 2014

Staff attitude towards cocaine/crack-cocaine use amongst individuals with severe mental health problems in an inner city area of the UK

article

Surgical Outcome of Ileal Pouch—Anal Anastomosis When Used Intentionally for Well-Defined Crohnʼs Disease ⬇️

scientific article published on January 1, 2013

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand

scientific article

TNFRSF1B Is Associated with ANCA in IBD.

scientific article

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

scientific article

The IBD International Genetics Consortium Provides Further Evidence for Linkage to IBD4 and Shows Gene-Environment Interaction

article

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants

scientific article published on 19 August 2003

The IL23 axis plays a key role in the pathogenesis of IBD.

scientific article published on October 2007

The Influence of Hormonal Fluctuation on Inflammatory Bowel Disease Symptom Severity-A Cross-Sectional Cohort Study.

scientific article published in January 2018

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

scientific article

The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction

scientific article published on 12 October 2016

The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience

scientific article published on 01 August 2019

The efficacy of methotrexate for maintaining remission in inflammatory bowel disease

scientific article

The genetic basis of spondyloarthritis: SPARTAN/IGAS 2009.

scientific article

The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery

scientific article published on March 2015

The role of glycosylation in IBD.

scientific article

Thiopurine therapy: when to start and when to stop

scientific article

Towards personalized care in IBD.

scientific article published on 17 December 2013

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

scientific article published on 22 September 2020

Tu1927 Genetically Driven Chromatin Organization Identifies Regulatory SNPs Associated With Crohn's Disease

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

scientific article

Variants in ZNF365 isoform D are associated with Crohn's disease ⬇️

scientific article published on January 21, 2011

Variation in treatment of patients with inflammatory bowel diseases at major referral centers in the United States

scientific article published on 21 November 2014

Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease.

scientific article

Winter is coming! Clinical, immunological, and practical considerations for vaccinating patients with IBD during the COVID pandemic

scientific article published on 13 October 2020

cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events

scientific article published on 25 May 2020

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