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List of works by Charles P Hart

14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment ⬇️

scientific article published on February 22, 2011

A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.

scientific article

ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.

scientific article published on April 2007

Activity of the hypoxia-activated prodrug, TH-302, in preclinical human acute myeloid leukemia models.

scientific article published on 2 October 2013

Cognate homeo-box loci mapped on homologous human and mouse chromosomes

scientific article

Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models

scientific article

Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.

scientific article published on 28 January 2016

DD-02PHARMACODYNAMIC BIOMARKER ASSESSMENTS IN A PHASE I/II TRIAL OF THE HYPOXIA-ACTIVATED PRODRUG TH-302 AND BEVACIZUMAB IN BEVACIZUMAB-REFRACTORY RECURRENT GLIOBLASTOMA

scientific article published in November 2014

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer

scientific article

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

scientific article published on 21 May 2015

Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer

scientific article

Genetic Recombination as a Reporter for Screening Steroid Receptor Agonists and Antagonists ⬇️

scientific article published on April 10, 1998

Genetic linkage analysis of the murine developmental mutant velvet coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1, Rar-g, Wnt-1, and Krt-2

scientific article published on August 1, 1992

Homeo box genes in murine development.

scientific article published on January 1987

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

scientific article published on October 29, 1992

Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models.

scientific article published on September 2016

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

scientific article published on March 6, 2012

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

scientific article published on 24 November 2015

Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas

scientific article

MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts

scientific article

Mammalian homeo box genes

scientific article published on 01 January 1985

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

scientific article

Molecular cloning and chromosome assignment of murine N-ras

scientific article

Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.

scientific article published in October 1984

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

scientific article

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

scientific article

Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.

scientific article published on 20 July 2016

Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

scientific article

Reproducible subcellular alterations in hepatocytes resulting from ultrasound

scientific article published on 01 January 1980

Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.

scientific article

Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons.

scientific article published on October 1987

Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.

scientific article published in March 1986

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.

scientific article published on 24 March 2015

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.

scientific article published on 02 March 2012

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