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List of works by Xiaofei Liang

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.

scientific article published on 29 April 2016

Ammonia Induces Autophagy through Dopamine Receptor D3 and MTOR

scientific article

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.

scientific article

Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmo

scientific article published on 12 November 2020

Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor

scientific article published on 17 July 2018

Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome

scientific article published on 31 January 2017

Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia

scientific article published on 08 January 2019

Drug design from the cryptic inhibitor envelope

scientific article published on 25 February 2016

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

scientific article published on 20 June 2016

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.

scientific article

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design ⬇️

scientific article published on December 16, 2010

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

scientific article

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

scientific article

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