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List of works by Trygve O. Tollefsbol

2D Difference Gel Electrophoresis Analysis of Different Time Points during the Course of Neoplastic Transformation of Human Mammary Epithelial Cells ⬇️

scientific article published on December 20, 2010

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

scientific article

A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells

scientific article

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells ⬇️

scientific article published on March 16, 2011

A method to detect DNA methyltransferase I gene transcription in vitro in aging systems

scientific article published on January 2007

A method to study the expression of DNA methyltransferases in aging systems in vitro

scientific article published on January 2007

Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

scientific article (publication date: 16 May 2001)

Advances in Epigenetic Technology ⬇️

scientific article published on January 1, 2011

Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases

scientific article

Aging and energetics' 'Top 40' future research opportunities 2010-2013.

scientific article

Aging cell culture: methods and observations

scientific article published on January 2007

Aging, cancer and nutrition: the DNA methylation connection

scientific article published on December 2003

An integrated analysis of the effects of maternal broccoli sprouts exposure on transcriptome and methylome in prevention of offspring mammary cancer

scientific article published on 09 March 2022

Analysis inEscherichia coliof the Effects ofin VivoCpG Methylation Catalyzed by the Cloned Murine Maintenance Methyltransferase ⬇️

scientific article published on April 28, 1998

Analysis of biomarkers of caloric restriction in aging cells

scientific article published on January 2013

Analysis of telomerase activity and detection of its catalytic subunit, hTERT.

scientific article

Assessment of telomere length and factors that contribute to its stability

scientific article

Bioactive Dietary Supplements Reactivate ER Expression in ER-Negative Breast Cancer Cells by Active Chromatin Modifications ⬇️

scientific article published on May 25, 2012

Carbohydrate metabolism in transforming lymphocytes from the aged

scientific article published on 01 June 1985

Cell senescence culturing methods.

scientific article published on January 2013

Collaborative Molecular Epidemiology Study of Metabolic Dysregulation, DNA Methylation, and Breast Cancer Risk Among Nigerian Women: MEND Study Objectives and Design

scientific article published on 01 June 2019

Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic⁻Mediating Machinery

scientific article published on 27 July 2018

Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy

scientific article published on 14 September 2019

Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells

scientific article published on 12 December 2015

Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression

scientific article published on 24 August 2017

Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals

scientific article published on August 2016

Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice

scientific article published on 13 November 2020

Combined Chromatin Immunoprecipitation and Bisulfite Methylation Sequencing Analysis ⬇️

scientific article published on January 1, 2011

Computational methods and next-generation sequencing approaches to analyze epigenetics data: Profiling of methods and applications

scientific article published on 14 September 2020

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells

scientific article

Control of methylation spreading in synthetic DNA sequences by the murine DNA methyltransferase ⬇️

scientific article published on June 20, 1997

Could epigenetics help explain racial disparities in chronic pain?

scientific article published on 18 February 2019

Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes

scientific article published on 01 January 1985

DNA methylation detection: bisulfite genomic sequencing analysis

scientific article published on January 2011

DNA methylation impacts on learning and memory in aging

scientific article published on 11 September 2007

DNA methylation methods: global DNA methylation and methylomic analyses

scientific article published on 08 October 2020

Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age

scientific article published on 01 April 1985

Dietary epigenetics in cancer and aging

scientific article

Differential expression of epigenetic modulators during human embryonic stem cell differentiation

scientific article published on 25 October 2008

Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts ⬇️

scientific article published on January 1, 2002

Display of adenoregulin with a novel Pichia pastoris cell surface display system

scientific article

Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene

scientific article published on 23 March 2016

EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis.

scientific article

EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase

scientific article published on 08 August 2008

Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells

scientific article published on 27 December 2018

Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane

scientific article published on 17 February 2013

Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation.

scientific article published on 16 January 2013

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

scientific article

Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG

scientific article published on February 2008

Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory.

scientific article published on 11 December 2017

Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems

scientific article

Epigenetic diet: impact on the epigenome and cancer ⬇️

scientific article published on August 1, 2011

Epigenetic linkage of aging, cancer and nutrition

scientific article

Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells

scientific article published on January 2009

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

scientific article published on 4 February 2013

Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells

scientific article published on 25 February 2015

Epigenetic regulation of caloric restriction in aging ⬇️

scientific article published on August 25, 2011

Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation

scientific article published in September 2004

Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein

scientific article

Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells

scientific article published on March 2008

Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.

scientific article published on 19 August 2010

Epigenetic targets of bioactive dietary components for cancer prevention and therapy ⬇️

scientific article published on December 1, 2010

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

scientific article published on 12 October 2015

Epigenomics of ovarian cancer and its chemoprevention

scientific article published on 4 October 2011

Erratum to "Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 cancer cells with PX-866 and Raloxifene" [Exp. Cell Res. 344 (2016) 95-102]

scientific article published on 02 June 2016

Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

scientific article published on 25 October 2006

Expression of intracellular biochemical defects of lymphocytes in aging: proposal of a general aging mechanism which is not cell-specific

scientific article

Gene expression of carbohydrate metabolism in cellular senescence and aging

scientific article published on October 1987

Gene-environment interactions and epigenetic basis of human diseases

scientific article published on January 2008

Genetic and epigenetic modulation of telomerase activity in development and disease

scientific article

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms

scientific article

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

scientific article

Identification of DNA methylation associated enrichment pathways in adults with non-specific chronic low back pain

scientific article published on 01 January 2020

Impact of Epigenetic Dietary Components on Cancer through Histone Modifications

scientific article published on January 2015

Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer

scientific article

Impact of epigenetic dietary compounds on transgenerational prevention of human diseases

scientific article published on 11 October 2013

Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition

scientific article published on 21 December 2017

Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components

scientific article

Impaired glycolysis of human lymphocytes during aging ⬇️

scientific article published on 01 December 1981

Increased lability of triosephosphate isomerase in progeria and Werner's syndrome fibroblasts

scientific article published on 01 October 1982

Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements ⬇️

scientific article published on October 16, 2003

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

scientific article

Insufficient DNA methylation affects healthy aging and promotes age-related health problems ⬇️

scientific article published on June 12, 2011

Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death

scientific article published on 27 February 2006

Mammalian DNA (Cytosine-5-)-methyltransferase Expressed in Escherichia coli, Purified and Characterized ⬇️

scientific article published on 01 August 1995

Maternal epigenetic regulation contributes to prevention of estrogen receptor-negative mammary cancer with broccoli sprout consumption

scientific article published on 17 March 2020

Mechanisms for methylation-mediated gene silencing and aging

scientific article published on 01 July 1993

Mechanisms for telomerase gene control in aging cells and tumorigenesis

scientific article published in June 2001

Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation

scientific article published on 5 February 2017

Medicinal chemistry of the epigenetic diet and caloric restriction

scientific article published on January 2013

Methods of epigenetic analysis

scientific article published in January 2004

Methods of telomerase inhibition

scientific article published on January 2007

Methylated-CpG Island Recovery Assay

scientific article published on January 2011

MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer

scientific article published on 08 October 2019

MicroRNAs: an emerging science in cancer epigenetics ⬇️

scientific article published on March 16, 2013

Mitochondrial regulation of epigenetics and its role in human diseases ⬇️

scientific article published on April 1, 2012

Molecular basis of the accumulation of abnormal proteins in progeria and aging fibroblasts

Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate

scientific article published on 8 February 2014

Molecular resurrection of an extinct ancestral promoter for mouse L1.

scientific article

Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor-negative transgenic mice

scientific article published on 31 December 2020

Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis

scientific article published on April 2014

Polyphenols and aging

scientific article

Prenatal epigenetics diets play protective roles against environmental pollution

scientific article published on 16 May 2019

Profiling DNA methylation by bisulfite genomic sequencing: problems and solutions

scientific article published on 01 January 2004

Proteolytic modification of human phosphoglycerate kinase from lymphoblasts

scientific article published on 01 November 1980

Pterostilbene down-regulates hTERT at physiological concentrations in breast cancer cells: Potentially through the inhibition of cMyc.

scientific article published on 10 November 2017

RETRACTED: Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice ⬇️

scientific article published on December 24, 2010

RNA interference using a plasmid construct expressing short-hairpin RNA

scientific article published on January 2007

Real-time methylomic aberrations during initiation and progression of induced human mammary epithelial cell tumorigenesis

scientific article published on April 2013

Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

scientific article

Regulation of the human catalytic subunit of telomerase (hTERT) ⬇️

scientific article published on February 13, 2012

Retinoid-induced histone deacetylation inhibits telomerase activity in estrogen receptor-negative breast cancer cells.

scientific article

Retrovirus-mediated RNA interference. Targeting hTERT through stable expression of short-hairpin RNA.

scientific article

Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases

scientific article published on April 1986

SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2

scientific article published on 01 January 2020

Strategies targeting telomerase inhibition

scientific article published on 28 October 2008

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines

scientific article

Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells ⬇️

scientific article published on October 14, 2010

Systematic integrated analyses of methylomic and transcriptomic impacts of early combined botanicals on estrogen receptor-negative mammary cancer

scientific article published on 04 May 2021

Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology

scientific article published on 21 February 2019

Targeting cancer epigenetics with CRISPR-dCAS9: Principles and prospects

scientific article published on 18 April 2020

Techniques for analysis of biological aging

scientific article published on January 2007

Telomerase inhibition by retinoids precedes cytodifferentiation of leukemia cells and may contribute to terminal differentiation

scientific article published on August 2004

Telomerase inhibition in cancer therapeutics: molecular-based approaches

scientific article published on January 2006

Telomerase, telomerase inhibition, and cancer

scientific article published on January 2003

Telomeres and telomerase: basic science implications for aging

scientific article

Telomeres, telomerase, and telomerase inhibition: clinical implications for cancer

scientific article

Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms

scientific article published on 15 May 2018

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation.

scientific article published on 13 June 2018

The Epigenetic Connection Between the Gut Microbiome in Obesity and Diabetes

scientific article published on 01 January 2019

The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention

scientific article

The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

scientific article published on 18 September 2020

The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells

scientific article published on September 2008

The Role of Non-coding RNAs and Isothiocyanates in Cancer.

scientific article published on 12 March 2018

The Role of Nutraceuticals in Chemoprevention and Chemotherapy and Their Clinical Outcomes ⬇️

scientific article published on December 7, 2011

The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes

scientific article published on 01 July 1984

The effects of aging on phosphofructokinase induction during lymphocyte mitogenesis in relation to DNA and protein synthesis

scientific article published on 01 June 1987

The impact of metabolism on DNA methylation

scientific article

The influence of an epigenetics diet on the cancer epigenome.

scientific article published on 11 August 2017

The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells

scientific article published on March 2007

The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis

scientific article published on 01 December 1990

The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention ⬇️

scientific article published on January 26, 2011

Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis

scientific article published on 12 June 2008

Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts

scientific article published on October 1, 2003

Transforming Cancer Epigenetics Using Nutritive Approaches and Non-coding RNAs

scientific article published on 3 February 2017

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms.

scientific article published on 21 April 2018

hTERT knockdown in human embryonic kidney cells using double-stranded RNA

scientific article published on January 2007

p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms ⬇️

scientific article published on February 24, 2011

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