List of works by Paul M Kaye

A Petri net model of granulomatous inflammation: implications for IL-10 mediated control of Leishmania donovani infection

scientific article

A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovani infection.

scientific article published on August 2002

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH.

scientific article

A transcriptomic network identified in uninfected macrophages responding to inflammation controls intracellular pathogen survival.

scientific article published on September 2013

Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.

scientific article published in January 2006

Altered course of visceral leishmaniasis in mice expressing transgenic I-E molecules

scientific article published on February 1, 1992

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies.

scholarly article

An in vivo analysis of cytokine production during Leishmania donovani infection in scid mice.

scientific article published on November 1996

Antigen presentation and the response to parasitic infection.

scientific article published on October 1987

Antigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon-gamma by allogeneic T cells

scientific article published on 01 November 1991

Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.

scientific article published on September 1993

B cell: T cell interactions occur within hepatic granulomas during experimental visceral leishmaniasis

scientific article

Bile canalicular dynamics in hepatocyte sandwich cultures

scientific article published on 18 August 2015

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

scientific article published on June 2016

Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development

scientific article

CD4 T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis

scientific article published on 18 December 2018

CD4+ Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production

scientific article (publication date: 22 September 2016)

CD8+ T-cell priming regulated by cytokines of the innate immune system.

scientific article published in August 2004

CD95 is required for the early control of parasite burden in the liver of Leishmania donovani-infected mice.

scientific article published on April 2001

Cervico-vaginal immunoglobulin G levels increase post-ovulation independently of neutrophils

scientific article

Chronic Leishmania donovani infection promotes bystander CD8+-T-cell expansion and heterologous immunity

scientific article

Co-stimulatory activity of Leishmania-infected macrophages: reply

scientific article published on 01 July 1995

Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds

scientific article published on 7 July 2009

Compartment-specific remodeling of splenic micro-architecture during experimental visceral leishmaniasis.

scientific article

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection

scientific article

Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis

scientific article published on 18 November 2002

Deficient expression of co-stimulatory molecules on Leishmania-infected macrophages.

scientific article published on November 1994

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

scientific article

Dendritic cells at the host-pathogen interface.

scientific article

Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen. ⬇️

scientific article published on 16 November 2009

Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells

scientific article published on July 2006

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection.

scientific article

Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells

scientific article (publication date: March 2010)

Enhanced hematopoietic activity accompanies parasite expansion in the spleen and bone marrow of mice infected with Leishmania donovani

scientific article

Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation.

scientific article published on April 1997

Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection

scientific article published on December 2007

Functional analysis of Leishmania cyclopropane fatty acid synthetase

scientific article

IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis

scientific article

IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells.

scientific article

Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis.

scientific article published on 04 June 2007

Immunomodulators: use in combined therapy against leishmaniasis

scientific article published on 01 July 2010

Immunomodulatory Therapy of Visceral Leishmaniasis in Human Immunodeficiency Virus-Coinfected Patients.

scientific article published in January 2017

Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani.

scientific article published on May 2004

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.

scientific article

In vivo recognition of ovalbumin expressed by transgenic Leishmania is determined by its subcellular localization.

scientific article published on April 2006

Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice

scientific article

Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7

scientific article

Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver.

scientific article

Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection

scientific article

Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation

scientific article

Leishmania-induced inhibition of macrophage antigen presentation analyzed at the single-cell level

scientific article published on December 2003

Leishmaniasis: complexity at the host-pathogen interface.

scientific article published on 11 July 2011

Lessons from other diseases: granulomatous inflammation in leishmaniasis

scientific article (publication date: March 2016)

Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19.

scientific article published on October 2004

Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria

scientific article published on May 2002

Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21.

scientific article published on May 2006

M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis

scientific article published on 23 October 2015

Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling.

scientific article published on 27 March 2018

Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis

scientific article

Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells

scientific article published on 22 April 2020

Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses.

scientific article

Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani.

scientific article published on February 1998

Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate

scientific article

Post kala-azar dermal leishmaniasis: an unresolved mystery

scientific article published on 02 January 2014

Postgenomic research on leishmaniasis: a critical self-appraisal

scientific article (publication date: September 2008)

Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.

scientific article

Presentation ofLeishmania donovani promastigotes occurs via a brefeldin A-sensitive pathway ⬇️

scientific article published on October 1, 1991

Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum.

scientific article published in May 2005

Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice

scientific article published on 04 July 2016

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis.

scientific article

Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following Toll-like receptor 2 stimulation in THP-1 monocytes

scientific article published on 11 June 2013

Role of Lsh in regulating macrophage priming/activation.

scientific article published on October 1989

Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition

scientific article published on 06 February 2017

Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice

scientific article

Skin parasite landscape determines host infectiousness in visceral leishmaniasis

scientific article

Stromal Cell Responses in Infection

scientific article published on 01 January 2018

Stromal cell induction of regulatory dendritic cells.

scientific article published on 21 August 2012

Stromal cell-derived CXCL12 and CCL8 cooperate to support increased development of regulatory dendritic cells following Leishmania infection

scientific article published on 12 July 2010

Stromal cells direct local differentiation of regulatory dendritic cells

scientific article

Stromal-cell regulation of dendritic-cell differentiation and function

scientific article published on 17 October 2006

TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis

scientific article published on 3 July 2017

Tegumentary leishmaniasis and coinfections other than HIV.

scientific article published in March 2018

Temporal regulation of interleukin-12p70 (IL-12p70) and IL-12-related cytokines in splenic dendritic cell subsets during Leishmania donovani infection.

scientific article

The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani

scientific article

The fate of heterologous CD4+ T cells during Leishmania donovani infection.

scientific article

The immunopathology of experimental visceral leishmaniasis

scientific article published in October 2004

The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review

scientific article published on 17 October 2019

The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection

scientific article

The role of dendritic cells in the induction and regulation of immunity to microbial infection.

scientific article

Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasis.

scientific article published on February 2012

Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis

scientific article published on 01 January 2018

Tissue cytokine responses in canine visceral leishmaniasis

scientific article published on 21 March 2001

Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection

scientific article published on 14 March 2014

Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

scientific article published on 10 December 2019

Transgenic Leishmania and the immune response to infection

scientific article published on 04 February 2008

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.

scientific article

VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis

scientific article

miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity

scientific article published on 04 March 2019

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