List of works - Lea Eisenbach

'1-8 interferon inducible gene family': putative colon carcinoma-associated antigens.

scientific article published on 11 December 2007

A novel lytic peptide composed of DL-amino acids selectively kills cancer cells in culture and in mice

scientific article published on 19 March 2003

A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice.

scientific article

A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival

scientific article published on 05 December 2018

Adenosine 3',5'-monophosphate suppresses metastatic spread in nude mice of steroidogenic rat granulosa cells transformed by simian virus-40 and Ha-ras oncogene

scientific article published on July 1, 1992

Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens

scientific article published on 01 January 2002

Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells

scientific article published on 01 February 1993

Anti-tumor vaccination in heterozygous congenic F1 mice: presentation of tumor-associated antigen by the two parental class I alleles

scientific article published on 01 May 2000

Antigenicity and immunogenicity of an intracellular delivery system of major histocompatibility complex class I epitopes that bypasses proteasome processing.

scientific article

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine interleukin 12

scientific article published on 01 October 1998

Antitumor vaccination using peptide based vaccines.

scientific article

Biochemical studies of the excitable membrane of paramecium tetraurelia. IX. Antibodies against ciliary membrane proteins.

scientific article

CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity.

scientific article published on March 2002

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

scientific article published in Nature

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

scientific article published on 01 May 1994

Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs

scientific article

Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/D(b)-beta2m transgenic mice

scientific article

Combined dendritic cell cryotherapy of tumor induces systemic antimetastatic immunity.

scientific article published in July 2005

Combined therapy with IL-6 and inactivated tumor cells suppresses metastasis in mice bearing 3LL lung carcinomas

scientific article published on 01 March 1993

Coupling presentation of MHC class I peptides to constitutive activation of antigen-presenting cells through the product of a single gene

scientific article published on 07 June 2011

Cryoimmunotherapy with local co-administration of ex vivo generated dendritic cells and CpG-ODN immune adjuvant, elicits a specific antitumor immunity.

scientific article published on 23 January 2014

DAP kinase links the control of apoptosis to metastasis

scientific article published in Nature

Development of novel genetic cancer vaccines based on membrane-attached β2 microglobulin

scientific article published on 06 February 2013

Differentiation patterns of CD4/CD8 thymocyte subsets in cocultures of fetal thymus and lymphohemopoietic cells from c-fos transgenic and normal mice

scientific article published in May 1992

Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity

scientific article

Effective anti-metastatic melanoma vaccination with tumor cells transfected with MHC genes and/or infected with Newcastle disease virus (NDV).

scientific article published in December 1994

Electrophoretic mobility of membrane fragments on a sucrose gradient. Application to isolated purple membrane fragments from Halobacterium halobium

scientific article published on January 1979

Expression of FasL by tumor cells does not abrogate anti-tumor CTL function.

scientific article published in February 2004

Exuberated numbers of tumor-specific T cells result in tumor escape.

scientific article

G6PD molecules devoid of catalytic activity are present in the nucleus of the rat lens

scientific article published on 01 May 1986

H-2Db gene transfer into highly metastatic D122 cells results in tumor rejection in allogeneic recipients, but does not affect metastasis in syngeneic recipients. Implications for mechanisms of allorejection

scientific article published on 01 November 1992

Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy

scientific article published on July 2005

IFNgamma secretion following stimulation with total tumor peptides from autologous human tumors

scientific article published on 01 July 2000

Immunogenic capacity of macrophage hybridomas.

scientific article published in January 1989

Immunogenicity of H-2Kb-low affinity, high affinity, and covalently-bound peptides in anti-tumor vaccination.

scientific article published in October 1999

In vivo rejection of tumor cells dependent on CD8 cells that kill independently of perforin and FasL.

scientific article published on March 2004

Induction of antitumor immunity by CTL epitopes genetically linked to membrane-anchored beta2-microglobulin

scientific article published on 01 January 2006

Induction of antitumor immunity with modified autologous cells expressing membrane-bound murine cytokines

scientific article published on 01 December 1999

Interleukin-6: effects on tumor models in mice and on the cellular regulation of transcription factor IRF-1

scientific article published on 01 July 1995

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells

scientific article

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

scientific article

MAGE-A8 overexpression in transitional cell carcinoma of the bladder: identification of two tumour-associated antigen peptides

scientific article published on July 2004

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

scientific article published on 01 October 1999

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

scientific article published on 01 July 1983

Membrane-anchored beta 2-microglobulin stabilizes a highly receptive state of MHC class I molecules.

scientific article published on February 2005

Modification of PDGFalpha receptor expression or function alters the metastatic phenotype of 3LL cells

scientific article published on 01 September 1997

Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cells

scientific article

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

scientific article published on 3 January 2018

Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues

scientific article published on 01 March 2004

O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma.

scientific article published on January 2006

Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models

scientific article published on 26 March 2018

Optimizing T-cell receptor avidity with somatic hypermutation

scientific article published on 24 August 2019

Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive.

scientific article published on February 2008

Porcine carboxypeptidase B. Arsanilazocarboxypeptidase, spectral and functional consequences of modification of tyrosine-"248"

scientific article published on 01 February 1972

Preventive and therapeutic vaccination with PAP-3, a novel human prostate cancer peptide, inhibits carcinoma development in HLA transgenic mice.

scientific article

Production of LacZ inducible T cell hybridoma specific for human and mouse gp100₂₅₋₃₃ peptides

scientific article

Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug

scientific article published on 01 August 1993

Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

scientific article published on 01 November 1995

Selective targeting of melanoma and APCs using a recombinant antibody with TCR-like specificity directed toward a melanoma differentiation antigen.

scientific article

Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells.

scientific article published on 12 October 2011

T cell vaccination induces the elimination of EAE effector T cells: analysis using GFP-transduced, encephalitogenic T cells

scientific article published on 26 June 2010

T-cell seeding: neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of experimental autoimmune encephalitis

scientific article

T-cell subset analysis of 3LL tumor growth ⬇️

scientific article published on January 1, 1991

The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

scientific article published on 13 December 2017

The differential expression of H-2K versus H-2D antigens, distinguishing high-metastatic from low-metastatic clones, is correlated with the immunogenic properties of the tumor cells.

scientific article published on October 1984

The effect of age on the regulation of glucose-6-phosphate dehydrogenase in mouse liver.

scientific article published in January 1976

The expression of PDGF-alpha but not PDGF-beta receptors is suppressed in Swiss/3T3 fibroblasts over-expressing protein kinase C-alpha

scientific article published on April 1994

The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene.

scientific article

The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients

scientific article published on 06 November 2003

The use of [35S]methionine as a target cell label in long term cytotoxic assays

scientific article published on 01 May 1992

Trogocytosis of MHC-I/peptide complexes derived from tumors and infected cells enhances dendritic cell cross-priming and promotes adaptive T cell responses.

scientific article

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

scientific article published on 12 September 2019

Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: growth inhibition and differentiation of B16-F10.9 tumor cells

scientific article published on 01 July 1997

c-fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence.

scientific article published in June 1990

mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model

scientific article published on 22 April 2016

mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity

scientific article published on 22 May 2015

“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation.

scientific article published on 7 November 2013

List of works by Lea Eisenbach

'1-8 interferon inducible gene family': putative colon carcinoma-associated antigens.

A novel lytic peptide composed of DL-amino acids selectively kills cancer cells in culture and in mice

A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice.

A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival

Adenosine 3',5'-monophosphate suppresses metastatic spread in nude mice of steroidogenic rat granulosa cells transformed by simian virus-40 and Ha-ras oncogene

Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens

Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells

Anti-tumor vaccination in heterozygous congenic F1 mice: presentation of tumor-associated antigen by the two parental class I alleles

Antigenicity and immunogenicity of an intracellular delivery system of major histocompatibility complex class I epitopes that bypasses proteasome processing.

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine interleukin 12

Antitumor vaccination using peptide based vaccines.

Biochemical studies of the excitable membrane of paramecium tetraurelia. IX. Antibodies against ciliary membrane proteins.

CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity.

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs

Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/D(b)-beta2m transgenic mice

Combined dendritic cell cryotherapy of tumor induces systemic antimetastatic immunity.

Combined therapy with IL-6 and inactivated tumor cells suppresses metastasis in mice bearing 3LL lung carcinomas

Coupling presentation of MHC class I peptides to constitutive activation of antigen-presenting cells through the product of a single gene

Cryoimmunotherapy with local co-administration of ex vivo generated dendritic cells and CpG-ODN immune adjuvant, elicits a specific antitumor immunity.

DAP kinase links the control of apoptosis to metastasis

Development of novel genetic cancer vaccines based on membrane-attached β2 microglobulin

Differentiation patterns of CD4/CD8 thymocyte subsets in cocultures of fetal thymus and lymphohemopoietic cells from c-fos transgenic and normal mice

Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity

Effective anti-metastatic melanoma vaccination with tumor cells transfected with MHC genes and/or infected with Newcastle disease virus (NDV).

Electrophoretic mobility of membrane fragments on a sucrose gradient. Application to isolated purple membrane fragments from Halobacterium halobium

Expression of FasL by tumor cells does not abrogate anti-tumor CTL function.

Exuberated numbers of tumor-specific T cells result in tumor escape.

G6PD molecules devoid of catalytic activity are present in the nucleus of the rat lens

H-2Db gene transfer into highly metastatic D122 cells results in tumor rejection in allogeneic recipients, but does not affect metastasis in syngeneic recipients. Implications for mechanisms of allorejection

Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy

IFNgamma secretion following stimulation with total tumor peptides from autologous human tumors

Immunogenic capacity of macrophage hybridomas.

Immunogenicity of H-2Kb-low affinity, high affinity, and covalently-bound peptides in anti-tumor vaccination.

In vivo rejection of tumor cells dependent on CD8 cells that kill independently of perforin and FasL.

Induction of antitumor immunity by CTL epitopes genetically linked to membrane-anchored beta2-microglobulin

Induction of antitumor immunity with modified autologous cells expressing membrane-bound murine cytokines

Interleukin-6: effects on tumor models in mice and on the cellular regulation of transcription factor IRF-1

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

MAGE-A8 overexpression in transitional cell carcinoma of the bladder: identification of two tumour-associated antigen peptides

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

Membrane-anchored beta 2-microglobulin stabilizes a highly receptive state of MHC class I molecules.

Modification of PDGFalpha receptor expression or function alters the metastatic phenotype of 3LL cells

Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cells

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues

O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma.

Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models

Optimizing T-cell receptor avidity with somatic hypermutation

Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive.

Porcine carboxypeptidase B. Arsanilazocarboxypeptidase, spectral and functional consequences of modification of tyrosine-"248"

Preventive and therapeutic vaccination with PAP-3, a novel human prostate cancer peptide, inhibits carcinoma development in HLA transgenic mice.

Production of LacZ inducible T cell hybridoma specific for human and mouse gp100₂₅₋₃₃ peptides

Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug

Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

Selective targeting of melanoma and APCs using a recombinant antibody with TCR-like specificity directed toward a melanoma differentiation antigen.

Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells.

T cell vaccination induces the elimination of EAE effector T cells: analysis using GFP-transduced, encephalitogenic T cells

T-cell seeding: neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of experimental autoimmune encephalitis

T-cell subset analysis of 3LL tumor growth ⬇️

The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

The differential expression of H-2K versus H-2D antigens, distinguishing high-metastatic from low-metastatic clones, is correlated with the immunogenic properties of the tumor cells.

The effect of age on the regulation of glucose-6-phosphate dehydrogenase in mouse liver.

The expression of PDGF-alpha but not PDGF-beta receptors is suppressed in Swiss/3T3 fibroblasts over-expressing protein kinase C-alpha

The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene.

The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients

The use of [35S]methionine as a target cell label in long term cytotoxic assays

Trogocytosis of MHC-I/peptide complexes derived from tumors and infected cells enhances dendritic cell cross-priming and promotes adaptive T cell responses.

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: growth inhibition and differentiation of B16-F10.9 tumor cells

c-fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence.

mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model

mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity

“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation.