List of works - Timothy D Le Cras

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

scientific article

Angiopoietins as serum biomarkers for lymphatic anomalies.

scientific article

Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice

scientific article

Comment on: Potential biomarkers of kaposiform lymphangiomatosis

scientific article published on 23 December 2019

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation

scientific article published on 30 April 2020

Diesel exhaust particle exposure increases severity of allergic asthma in young mice.

scientific article published in December 2013

Diesel exhaust particle induction of IL-17A contributes to severe asthma

scientific article published on 20 September 2013

Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma

scientific article

Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma

scientific article (publication date: 2013)

Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress ⬇️

scientific article published on May 13, 2011

Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

scientific article published on 27 January 2014

Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization

scientific article

Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice

scientific article published on 02 February 2009

Effects of Chronic Hypoxia and Altered Hemodynamics on Endothelial Nitric Oxide Synthase and Preproendothelin-1 Expression in the Adult Rat Lung ⬇️

scientific article published on July 1, 1998

Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.

scientific article

Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease

scientific article published on 11 August 2015

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

scientific article

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.

scientific article

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium

scientific article

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis

scientific article

IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation

scientific article published on 11 June 2016

Independent and combined effects of airway remodelling and allergy on airway responsiveness

scientific article published on 02 February 2018

Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis

scientific article

Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin-2 levels

scientific article published on 07 July 2020

Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.

scientific article published on 14 June 2004

Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease.

scientific article

Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.

scientific article published on 27 April 2007

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization ⬇️

scientific article published on September 26, 2010

Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma.

scientific article published on 21 October 2011

Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease.

scientific article published on 8 September 2011

Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

scientific article

Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term.

scientific article published in July 2000

Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus ⬇️

scientific article published on January 1, 1998

Signaling pathways and inhibitors of cells from patients with kaposiform lymphangiomatosis

scientific article published on 02 May 2019

Sox17 is required for normal pulmonary vascular morphogenesis

scientific article published on 10 January 2014

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

scientific article

Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.

scientific article

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.

scientific article published on 19 March 2004

Vascular changes after intra-amniotic endotoxin in preterm lamb lungs.

scientific article

Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice.

scientific article published on 19 November 2004

Vascular growth and remodeling in compensatory lung growth following right lobectomy

scientific article published on 29 October 2004

p27Kip1 Is Important in Modulating Pulmonary Artery Smooth Muscle Cell Proliferation ⬇️

scientific article published on November 1, 2001

List of works by Timothy D Le Cras

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

Angiopoietins as serum biomarkers for lymphatic anomalies.

Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice

Comment on: Potential biomarkers of kaposiform lymphangiomatosis

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation

Diesel exhaust particle exposure increases severity of allergic asthma in young mice.

Diesel exhaust particle induction of IL-17A contributes to severe asthma

Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma

Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma

Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress ⬇️

Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization

Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice

Effects of Chronic Hypoxia and Altered Hemodynamics on Endothelial Nitric Oxide Synthase and Preproendothelin-1 Expression in the Adult Rat Lung ⬇️

Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.

Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis

IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation

Independent and combined effects of airway remodelling and allergy on airway responsiveness

Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis

Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin-2 levels

Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.

Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease.

Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization ⬇️

Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma.

Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease.

Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term.

Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus ⬇️

Signaling pathways and inhibitors of cells from patients with kaposiform lymphangiomatosis

Sox17 is required for normal pulmonary vascular morphogenesis

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.

Vascular changes after intra-amniotic endotoxin in preterm lamb lungs.

Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice.

Vascular growth and remodeling in compensatory lung growth following right lobectomy

p27Kip1 Is Important in Modulating Pulmonary Artery Smooth Muscle Cell Proliferation ⬇️