List of works by Martha Lappas

2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients

scientific article published on 15 February 2011

A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery.

scientific article published on 14 September 2016

A mobile health intervention promoting healthy gestational weight gain for women entering pregnancy at a high body mass index: the txt4two pilot randomised controlled trial

scientific article published on 20 February 2017

A novel role for GSK3 in the regulation of the processes of human labour

scientific article published on February 2015

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

scientific article published on 26 September 2016

A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes.

scientific article published on September 2017

ATF3 is a negative regulator of inflammation in human fetal membranes

scientific article

Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women

scientific article published on 25 September 2015

Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.

scientific article published on 26 January 2015

Activation of inflammasomes in adipose tissue of women with gestational diabetes

scientific article published on 17 September 2013

Adipose Tissue Exosomal Proteomic Profile Reveals a Role on Placenta Glucose Metabolism in Gestational Diabetes Mellitus

scientific article published on 01 May 2019

Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2

scientific article published on 01 May 2007

Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor

scientific article published on July 2011

Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells

scientific article

Antiinflammatory effects of the cyclopentenone isoprostane 15-A2-IsoP in human gestational tissues

scientific article published on 12 March 2007

Authors' reply re: Self-weighing and simple dietary advice for overweight and obese pregnant women to reduce obstetric complications without impact on quality of life: a randomised controlled trial

scientific article published on 21 February 2017

Autophagy, which is decreased in labouring fetal membranes, regulates IL-1β production via the inflammasome.

scientific article

Bromodomain protein BRD4 is increased in human placentas from women with early-onset preeclampsia.

scientific article

Caspase-1 activation is increased with human labour in foetal membranes and myometrium and mediates infection-induced interleukin-1β secretion.

scientific article published on 15 November 2013

Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women.

scientific article

Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators

scientific article published on 21 July 2014

Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes.

scientific article published in March 2011

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia.

scientific article published on 21 February 2013

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

scientific article published in February 2018

Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells

scientific article

Complement C5A regulates prolabor mediators in human placenta

scientific article published on 28 June 2012

Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery.

scientific article published on 4 January 2016

Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes

scientific article published on 27 September 2017

DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells.

scientific article

Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction

scientific article published on 23 February 2015

Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies

scientific article published on 16 August 2012

Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus.

scientific article published on 29 January 2009

Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue.

scientific article published on 2 December 2009

Diagnostic Accuracy of Maternal Serum Macrophage Inhibitory Cytokine-1 and Pregnancy-Associated Plasma Protein-A at 6–10 Weeks of Gestation to Predict Miscarriage

scientific article published in May 2012

Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro.

scientific article published on 05 June 2013

Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.

scientific article published on 7 March 2013

Differential expression of AP-1 proteins in human myometrium after spontaneous term labour onset

scientific article published on 19 April 2014

Divergent SATB1 expression across human life span and tissue compartments

scientific article published on 25 February 2019

Do Postpartum Levels of Apolipoproteins Prospectively Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes Mellitus?

scientific article published on 12 March 2018

Double stranded viral RNA induces inflammation and insulin resistance in skeletal muscle from pregnant women in vitro.

scientific article published on 14 February 2015

Effect of high oxygen on placental function in short-term explant cultures

scientific article published on 21 February 2007

Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes.

scientific article

Effect of pre-existing maternal obesity, gestational diabetes and adipokines on the expression of genes involved in lipid metabolism in adipose tissue

scientific article published on 24 October 2013

Effect of silibinin in reducing inflammatory pathways in in vitro and in vivo models of infection-induced preterm birth.

scientific article

Effect of spontaneous term labour on the expression of the NR4A receptors nuclear receptor related 1 protein (Nurr1), neuron-derived clone 77 (Nur77) and neuron-derived orphan receptor 1 (NOR1) in human fetal membranes and myometrium

scientific article published on 01 June 2016

Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes.

scientific article published on 11 September 2013

Effects of maternal obstructive sleep apnoea on fetal growth: a prospective cohort study.

scientific article published on 24 July 2013

Endocan expression is increased in the placenta from obese women with gestational diabetes mellitus.

scientific article

Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.

scientific article published on 6 August 2014

Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes

scientific article

Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women.

scientific article

Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium

scientific article published on 13 March 2019

Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranes.

scientific article published on 8 October 2010

Expression and regulation of metallothioneins in myometrium and fetal membranes

scientific article published on 28 August 2018

Expression of Myostatin in Intrauterine Growth Restriction and Preeclampsia Complicated Pregnancies and Alterations to Cytokine Production by First-Trimester Placental Explants Following Myostatin Treatment

scientific article published on 02 March 2015

Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus

scientific article published on 16 October 2020

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

scientific article published on 10 November 2018

Forkhead box O1 (FOXO1) in pregnant human myometrial cells: a role as a pro-inflammatory mediator in human parturition.

scientific article published on 15 June 2013

Formyl peptide receptor-2 is decreased in fetal growth restriction and contributes to placental dysfunction.

scientific article published on 20 December 2017

GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†

scientific article published on 01 June 2019

GSK3β is increased in adipose tissue and skeletal muscle from women with gestational diabetes where it regulates the inflammatory response

scientific article

Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle

scientific article

Gestational weight gain information: seeking and sources among pregnant women

scientific article published on 7 August 2015

Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA.

scientific article published on 3 May 2017

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

scientific article published on 27 January 2020

Human cathelicidin antimicrobial protein 18 (hCAP18/LL-37) is increased in foetal membranes and myometrium after spontaneous labour and delivery.

scientific article published on 11 November 2014

Human labour is associated with decreased cytoplasmic FoxO4.

scientific article

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

scientific article published on 29 November 2018

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta

scientific article published on 19 January 2012

IRF5 is increased in labouring myometrium and regulates pro-labour mediators

scientific article published on 13 July 2018

Identification of SMAD3 as a Novel Mediator of Inflammation in Human Myometrium

scholarly article by Martha Lappas published 2018 in Mediators of Inflammation

In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes

scientific article published on 15 October 2009

In vitro selenium supplementation suppresses key mediators involved in myometrial activation and rupture of fetal membranes

scientific article published on 06 May 2020

Increased chemerin concentrations in fetuses of obese mothers and correlation with maternal insulin sensitivity

scientific article published on 17 May 2012

Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: possible role in human fetal membrane rupture.

scientific article published on 16 March 2009

Inhibition of GPR91 Reduces Inflammatory Mediators Involved in Active Labor in Myometrium

scientific article published on 15 April 2020

Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro.

scientific article

Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses

scientific article published on 31 July 2014

Inverse relationship between gestational weight gain and glucose uptake in human placenta from female foetuses.

scientific article published on 2 December 2013

KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium.

scientific article published on 16 February 2015

Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated k

scientific article published on 19 May 2005

Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cells.

scientific article published on 24 August 2005

Lipopolysaccharide and double stranded viral RNA mediate insulin resistance and increase system a amino acid transport in human trophoblast cells in vitro

scientific article published on 21 January 2017

Localisation and expression of FoxO1 proteins in human gestational tissues

scientific article published on 17 January 2009

Lower circulating levels of complement split proteins C3a and C4a in maternal plasma of women with gestational diabetes mellitus

scientific article published on 01 August 2011

MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes.

scientific article published on 2 October 2011

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin.

scientific article published on 31 January 2012

Markers of endothelial cell dysfunction are increased in human omental adipose tissue from women with pre-existing maternal obesity and gestational diabetes

scientific article published on 14 March 2014

Markers of protein synthesis are increased in fetal membranes and myometrium after human labour and delivery

scientific article published on 13 July 2017

Maternal 25-hydroxyvitamin D is inversely correlated with foetal serotonin.

scientific article

Maternal Prenatal Mental Health and Placental 11β-HSD2 Gene Expression: Initial Findings from the Mercy Pregnancy and Emotional Wellbeing Study

scientific article

Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study

scientific article

Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study.

scientific article published on 14 May 2013

Mercy Pregnancy and Emotional Well-being Study (MPEWS): Understanding maternal mental health, fetal programming and child development. Study design and cohort profile.

scientific article published on 25 January 2017

Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues

scientific article published on 16 April 2007

Myostatin in the placentae of pregnancies complicated with gestational diabetes mellitus

scientific article published in January 2015

N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro.

scientific article published in April 2003

NOD-like receptor pyrin domain-containing-3 (NLRP3) regulates inflammation-induced pro-labor mediators in human myometrial cells

scientific article published on 12 February 2018

NOD1 expression is increased in the adipose tissue of women with gestational diabetes

scientific article published on 14 May 2014

Neonatal adaptation following intrauterine antidepressant exposure: assessment, drug assay levels, and infant development outcomes

scientific article published on 16 August 2017

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

scientific article published on 01 March 2020

Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro.

scientific article

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells

scientific article

Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery

scientific article published on 01 June 2017

Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells

scientific article published on 14 April 2018

Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes

scientific article published on 13 December 2008

Perturbed CD8(+) T cell immunity across universal influenza epitopes in the elderly

scientific article published on 19 September 2017

Phospholipase A2 isozymes in pregnancy and parturition.

scientific article published on February 2004

Placental Pim-1 expression is increased in obesity and regulates cytokine- and toll-like receptor-mediated inflammation.

scientific article published on 13 April 2017

Placental Ras Regulates Inflammation Associated with Maternal Obesity

scientific article published on 08 October 2018

Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction

scientific article

Post-partum plasma C-peptide and ghrelin concentrations are predictive of type 2 diabetes in women with previous gestational diabetes mellitus.

scientific article published on 4 March 2015

Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life

scientific article published on 24 July 2019

Postpartum IGF-I and IGFBP-2 levels are prospectively associated with the development of type 2 diabetes in women with previous gestational diabetes mellitus

scientific article published on 4 July 2016

Postpartum maternal adipokines and infant weight for length at 1 year in women with gestational diabetes

scientific article published on 27 November 2017

Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium

scientific article published on 07 June 2018

Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappaB signalling pathways

scientific article published on 25 October 2008

Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor.

scientific article published on 11 March 2009

Preterm birth rate and dilemma of preterm labor treatment in Asia

scientific article published on 15 February 2019

Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction

scientific article published on 10 April 2013

Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

scientific article published on 01 January 2019

RAF1 is increased in labouring myometrium and modulates inflammation-induced pro-labour mediators.

scientific article published on 25 January 2016

RKIP is decreased in laboring myometrium and modulates inflammation-induced pro-labor mediators.

scientific article published in May 2017

Rational design of immunostimulatory siRNAs.

scientific article

Redefining 3Dimensional placental membrane microarchitecture using multiphoton microscopy and optical clearing.

scientific article published on 30 March 2017

Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone.

scientific article published in October 2002

Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus.

scientific article published in November 2004

Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle

scientific article

Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium.

scientific article published on 9 January 2018

SIRT1 is a novel regulator of key pathways of human labor.

scientific article published on 15 September 2010

SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes.

scientific article

SMAD7 regulates proinflammatory and prolabor mediators in amnion and myometrium.

scientific article

Screening for biomarkers predictive of gestational diabetes mellitus.

scientific article published on 22 May 2008

Self-weighing and simple dietary advice for overweight and obese pregnant women to reduce obstetric complications without impact on quality of life: a randomised controlled trial.

scientific article published on 14 February 2016

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.

scientific article

Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus

scientific article published on 16 August 2013

Slit2 exerts anti-inflammatory actions in human placenta and is decreased with maternal obesity.

scientific article published on 20 October 2014

Slit2 is decreased after spontaneous labour in myometrium and regulates pro-labour mediators.

scientific article

Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression

scientific article

Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.

scientific article published on 24 November 2004

TLR2, TLR3 and TLR5 regulation of pro-inflammatory and pro-labour mediators in human primary myometrial cells

scientific article

TRADD, TRAF2, RIP1 and TAK1 are required for TNF-α-induced pro-labour mediators in human primary myometrial cells.

scientific article published on 24 March 2017

TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization

scientific article published on 11 September 2013

Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization

scientific article published on 11 May 2009

Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

scientific article published on 01 December 2019

Testing the feasibility of a mobile technology intervention promoting healthy gestational weight gain in pregnant women (txt4two) - study protocol for a randomised controlled trial.

scientific article

The Adaptor Protein p62 Mediates Nuclear Factor κB Activation in Response to Inflammation and Facilitates the Formation of Prolabor Mediators in Human Myometrium.

scientific article published on 16 September 2016

The IL-1β signalling pathway and its role in regulating pro-inflammatory and pro-labour mediators in human primary myometrial cells.

scientific article

The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes

scientific article published on 27 August 2014

The Stress-responsive Heme Oxygenase (HO)-1 Isoenzyme is Increased in Labouring Myometrium where it Regulates Contraction-associated Proteins

scientific article published on 4 February 2015

The TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88/TRAF6/NF-κB-dependent signalling

scientific article published on 17 March 2014

The Transcription Factor Interferon Regulatory Factor-1 (IRF1) Plays a Key Role in the Terminal Effector Pathways of Human Preterm Labor.

scientific article published on 16 December 2015

The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth.

scientific article

The effect of pre-existing maternal obesity and diabetes on placental mitochondrial content and electron transport chain activity.

scientific article published on 26 June 2014

The effect of pre-existing maternal obesity on the placental proteome: two-dimensional difference gel electrophoresis coupled with mass spectrometry.

scientific article

The immunoproteasome inhibitor ONX-0914 regulates inflammation and expression of contraction associated proteins in myometrium

scientific article published on 28 June 2018

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics.

scientific article

The presence of coexisting sleep-disordered breathing among women with hypertensive disorders of pregnancy does not worsen perinatal outcome

scientific article published on 26 February 2020

The role and regulation of the nuclear factor kappa B signalling pathway in human labour.

scientific article published on 14 July 2006

The role of oxidative stress in the pathophysiology of gestational diabetes mellitus.

scientific article published on 04 August 2011

The transcription factor Nrf2 is decreased after spontaneous term labour in human fetal membranes where it exerts anti-inflammatory properties.

scientific article

Transcriptional regulation of the processes of human labour and delivery.

scientific article published on 17 November 2008

Type II phospholipase A2 in preterm human gestational tissues

scientific article published on 01 January 2001

Views of Women and Health Professionals on mHealth Lifestyle Interventions in Pregnancy: A Qualitative Investigation.

scientific article

Visfatin regulates the terminal processes of human labour and delivery via activation of the nuclear factor-κB pathway.

scientific article

Why do membranes rupture at term? Evidence of increased cellular apoptosis in the supracervical fetal membranes.

scientific article published on May 2007

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