List of works - Valentina Grossi

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

scientific article published on 3 January 2013

A rare MSH2 mutation causes defective binding to hMSH6, normal hMSH2 staining, and loss of hMSH6 at advanced cancer stage

scientific article published on 30 June 2014

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models ⬇️

scientific article published on May 11, 2012

Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape

scientific article published on 23 March 2019

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs

scientific article published on 13 June 2019

Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3'-end

scientific article published on 07 October 2019

Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay

scientific article published on 09 July 2019

In Silico Deciphering of the Potential Impact of Variants of Uncertain Significance in Hereditary Colorectal Cancer Syndromes

scientific article published on 6 August 2024

In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS).

scientific article published on 16 March 2018

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

scientific article published on 01 December 2018

Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.

scientific article

Molecular and Functional Characterization of Three Different Postzygotic Mutations in PIK3CA-Related Overgrowth Spectrum (PROS) Patients: Effects on PI3K/AKT/mTOR Signaling and Sensitivity to PIK3 Inhibitors.

scientific article published on 27 April 2015

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

scientific article published on 17 September 2012

Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38αKinase ⬇️

scientific article published on March 11, 2012

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

scientific article published on 9 November 2013

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.

scientific article published on 4 May 2018

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

scientific article published on 14 February 2018

Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer

scientific article published on 21 August 2012

p38alpha is required for ovarian cancer cell metabolism and survival.

scientific article

p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.

scientific article

List of works by Valentina Grossi

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

A rare MSH2 mutation causes defective binding to hMSH6, normal hMSH2 staining, and loss of hMSH6 at advanced cancer stage

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models ⬇️

Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs

Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3'-end

Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay

In Silico Deciphering of the Potential Impact of Variants of Uncertain Significance in Hereditary Colorectal Cancer Syndromes

In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS).

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.

Molecular and Functional Characterization of Three Different Postzygotic Mutations in PIK3CA-Related Overgrowth Spectrum (PROS) Patients: Effects on PI3K/AKT/mTOR Signaling and Sensitivity to PIK3 Inhibitors.

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38αKinase ⬇️

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer

p38alpha is required for ovarian cancer cell metabolism and survival.

p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.