List of works - Wanli Liu

A PI(4,5)P2-derived "gasoline engine model" for the sustained B cell receptor activation

scientific article published on 01 September 2019

A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

scientific article published in November 2017

A candidate vaccine against influenza virus intensively improved the immunogenicity of a neutralizing epitope.

scientific article

A new and robust method of tethering IgG surrogate antigens on lipid bilayer membranes to facilitate the TIRFM based live cell and single molecule imaging experiments

scientific article

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

scientific article

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

scientific article published in Science

Antigen Receptor Nanoclusters: Small Units with Big Functions

scientific article

Antigen affinity discrimination is an intrinsic function of the B cell receptor.

scientific article

Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.

scientific article

Behçet's disease complicated with thrombosis: a report of 93 Chinese cases.

scientific article

Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China

scientific article

Clinical analysis of 56 patients with rhupus syndrome: manifestations and comparisons with systemic lupus erythematosus: a retrospective case-control study

scientific article

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

scientific article published on 10 July 2019

Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity

scientific article published on 26 April 2019

Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

scientific article published on 14 December 2015

Encoding immunological memory in the initiation of B-cell receptor signaling

scientific article

Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses

scientific article published on 29 November 2017

Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs

scientific article

Farnesyl pyrophosphate is a new danger signal inducing acute cell death

scientific article published on 26 April 2021

Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function

scientific article published on 17 July 2019

FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding

scientific article published on 25 July 2019

Formation of BCR oligomers provides a mechanism for B cell affinity discrimination ⬇️

scientific article published on May 19, 2012

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells.

scientific article published on 26 June 2017

High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins.

scientific article published in February 2005

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232.

scientific article published on 31 October 2016

Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling

scientific article

Lipid in T-cell receptor transmembrane signaling

scientific article published on 30 April 2015

N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication.

scientific article published on March 2003

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

scientific article

PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation.

scientific article published on 23 April 2018

PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies

scientific article published on 06 June 2018

Probing Transient Release of Membrane-Sequestered Tyrosine-Based Signaling Motif by Solution NMR Spectroscopy

scientific article

Profiling the origin, dynamics, and function of traction force in B cell activation

scientific article published on 07 August 2018

Regulation of B cell fate by chronic activity of the IgE B cell receptor

scientific article published on 09 December 2016

SHIP-1 Deficiency in AID(+) B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity.

scientific article published on 2 October 2017

Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design.

scientific article published on 25 December 2004

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.

scientific article

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold.

scientific article

The epitope recognized by a monoclonal antibody in influenza A virus M2 protein is immunogenic and confers immune protection.

scientific article

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

scientific article (publication date: July 2012)

The molecular assembly and organization of signaling active B-cell receptor oligomers.

scientific article

The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors

scientific article

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

scientific article published on 15 May 2015

The tipping points in the initiation of B cell signalling: how small changes make big differences.

scientific article

Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19.

scientific article published on 30 April 2014

Transmembrane domain dependent inhibitory function of FcγRIIB.

scientific article published in March 2018

Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19).

scientific article published on 20 May 2014

Understanding of B Cell Receptor Signaling Through a Photo-Activatable Antigen Presentation System

scientific article published in January 2018

Understanding the Initiation of B Cell Signaling Through Live Cell Imaging ⬇️

scientific article published on January 1, 2012

List of works by Wanli Liu

A PI(4,5)P2-derived "gasoline engine model" for the sustained B cell receptor activation

A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

A candidate vaccine against influenza virus intensively improved the immunogenicity of a neutralizing epitope.

A new and robust method of tethering IgG surrogate antigens on lipid bilayer membranes to facilitate the TIRFM based live cell and single molecule imaging experiments

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

Antigen Receptor Nanoclusters: Small Units with Big Functions

Antigen affinity discrimination is an intrinsic function of the B cell receptor.

Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.

Behçet's disease complicated with thrombosis: a report of 93 Chinese cases.

Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China

Clinical analysis of 56 patients with rhupus syndrome: manifestations and comparisons with systemic lupus erythematosus: a retrospective case-control study

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity

Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

Encoding immunological memory in the initiation of B-cell receptor signaling

Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses

Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs

Farnesyl pyrophosphate is a new danger signal inducing acute cell death

Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function

FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding

Formation of BCR oligomers provides a mechanism for B cell affinity discrimination ⬇️

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells.

High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins.

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232.

Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling

Lipid in T-cell receptor transmembrane signaling

N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication.

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation.

PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies

Probing Transient Release of Membrane-Sequestered Tyrosine-Based Signaling Motif by Solution NMR Spectroscopy

Profiling the origin, dynamics, and function of traction force in B cell activation

Regulation of B cell fate by chronic activity of the IgE B cell receptor

SHIP-1 Deficiency in AID(+) B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity.

Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design.

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold.

The epitope recognized by a monoclonal antibody in influenza A virus M2 protein is immunogenic and confers immune protection.

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

The molecular assembly and organization of signaling active B-cell receptor oligomers.

The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

The tipping points in the initiation of B cell signalling: how small changes make big differences.

Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19.

Transmembrane domain dependent inhibitory function of FcγRIIB.

Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19).

Understanding of B Cell Receptor Signaling Through a Photo-Activatable Antigen Presentation System

Understanding the Initiation of B Cell Signaling Through Live Cell Imaging ⬇️