List of works - Heiko Düssmann

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

scientific article published on 05 January 2012

ALISSA: an automated live-cell imaging system for signal transduction analyses

scientific article

APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

scientific article published on 19 January 2007

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells

scientific article published on 22 December 2015

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study

scientific article published on 16 December 2020

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.

scientific article published on 25 May 2018

BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.

scientific article published on 05 October 2015

Bax regulates neuronal Ca2+ homeostasis.

scientific article

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

scientific article published on 27 August 2009

Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation

scientific article

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

scientific article published on February 2012

Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform

scientific article published on 16 November 2017

Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis

scientific article

Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

scientific article

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

scientific article published on 9 January 2009

ER stress signalling has an activating transcription factor 6α (ATF6)-dependent 'off-switch'

scientific article published in Journal of Biological Chemistry

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. ⬇️

scientific article

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. ⬇️

scientific article

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

scientific article

Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.

scientific article published on 22 October 2013

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1

scientific article published on 11 September 2018

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

scientific article published in August 2007

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

scientific article published in April 2012

Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.

scientific article published in November 2001

Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells.

scientific article published in January 2002

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

scientific article

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

scientific article

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

scientific article published on 3 June 2008

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

scientific article published on 18 April 2002

Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation

scientific article published in July 2014

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

scientific article published on 27 November 2013

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

scientific article

Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release

scientific article published on June 2017

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

scientific article

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells

scientific article published on 19 January 2018

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

scientific article published on 7 September 2008

The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

scientific article

The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.

scientific article published on January 2003

Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

scientific article

Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models.

scientific article

List of works by Heiko Düssmann

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

ALISSA: an automated live-cell imaging system for signal transduction analyses

APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.

BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.

Bax regulates neuronal Ca2+ homeostasis.

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform

Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis

Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

ER stress signalling has an activating transcription factor 6α (ATF6)-dependent 'off-switch'

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. ⬇️

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. ⬇️

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.

Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells.

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.

Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models.