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List of works by Markus S Huber-Lang

'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing

scientific article published on 18 April 2018

A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response

scientific article published on 29 February 2012

A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis

scientific article published on 26 July 2013

A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages

scientific article

Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury

scientific article

Acute lung injury induced by lipopolysaccharide is independent of complement activation

scientific article published on June 2008

Adrenergic regulation of complement-induced acute lung injury

scientific article published on January 2008

Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils

scientific article published in October 2007

Alteration of complement hemolytic activity in different trauma and sepsis models

scientific article

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

scientific article published on May 2002

Anti-complement Strategies in Experimental Sepsis ⬇️

scientific article published on January 1, 2003

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury ⬇️

scientific article published on March 1, 2013

Association of Kidney Tissue Barrier Disrupture and Renal Dysfunction in Resuscitated Murine Septic Shock

scientific article published on 25 February 2016

Association of adiponectin levels and insulin demand in critically ill patients ⬇️

scientific article published on January 26, 2011

Association of child maltreatment subtypes and long-term physical health in a German representative sample

article

Associations of adverse childhood experiences and bullying on physical pain in the general population of Germany

article

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

Author Correction: A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing.

scientific article published on 2 July 2018

Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma ⬇️

scientific article published on January 13, 2011

Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions

scientific article published on 12 September 2017

Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2.

scientific article published on 30 July 2015

Bride and groom in systemic inflammation – The bells ring for complement and Toll in cooperation ⬇️

scientific article published on November 1, 2012

C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing

scientific article published on 26 October 2016

C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing

scientific article published on 15 September 2011

C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10

scholarly article by Yvonne Mödinger et al published December 2018 in Journal of Cellular and Molecular Medicine

Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated mice

scientific article published in February 2010

Catecholamines and the septic heart: opening Pandora's box?

scientific article published in April 2013

Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?

scientific article

Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.

scientific article published on 14 January 2012

Challenge to the Intestinal Mucosa During Sepsis

Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans ⬇️

scientific article published on March 11, 2013

Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans

scientific article

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

scientific article published on 13 April 2019

Combined hemorrhage/trauma models in pigs-current state and future perspectives

scientific article published on October 2013

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis

scientific article

Complement After Trauma: Suturing Innate and Adaptive Immunity

Complement C3 and C5 deficiency affects fracture healing

scientific article

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.

scientific article

Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock.

scientific article published on 29 May 2018

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

scientific article published on 10 May 2017

Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation

scientific article

Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro

scientific article

Complement in Human Disease ⬇️

scientific article published on January 17, 2013

Complement in Pancreatic Disease-Perpetrator or Savior?

scientific article

Complement in Sepsis - when Science meets Clinics

scientific article published on 04 July 2020

Complement in lung disease

scientific article published on August 2006

Complement involvement in bone homeostasis and bone disorders

scientific article published on 29 January 2018

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

scientific article published on 25 October 2017

Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation - closing Pandora's box?

scientific article published on 3 May 2016

Complement-coagulation crosstalk on cellular and artificial surfaces

scientific article

Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction

scientific article published on June 2017

Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis

scientific article published on 19 August 2016

Complement-induced impairment of innate immunity during sepsis

scientific article (publication date: 15 September 2002)

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

scientific article

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F Osuchowski et al published October 2018 in Infection

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

scientific article published on 03 May 2019

Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways

scientific article

Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma

scientific article published on 6 January 2015

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

scientific article

Deceleration during 'real life' motor vehicle collisions - a sensitive predictor for the risk of sustaining a cervical spine injury?

scientific article published on 08 March 2009

Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin

scientific article

Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis.

scientific article published on 5 June 2018

Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study

scientific article

Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis ⬇️

scientific article published on December 30, 2011

Does complement play a role in bone development and regeneration?

scientific article published on 02 February 2012

Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice

scientific article published on 30 April 2014

Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma

scientific article

Early complementopathy after multiple injuries in humans

scientific article published on April 2012

Early structural changes of the heart after experimental polytrauma and hemorrhagic shock

scientific article published on 30 October 2017

Effects and sustainability of trainings for the oral and practical part of the German final exam in medicine

scientific article published on 15 August 2013

Effects of Prior Psychosocial Trauma on Subsequent Immune Response After Experimental Thorax Trauma

scientific article published on 25 August 2017

Effects of intrarenal administration of the calcium antagonist nimodipine during porcine aortic occlusion-induced ischemia/reperfusion injury

scientific article

Effects of intrarenal administration of the cox-2 inhibitor parecoxib during porcine suprarenal aortic cross-clamping

scientific article

Epinephrine kinetics in septic shock--a means to understand variable catecholamine efficiency?

scientific article published on 13 August 2009

Erratum to: Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

scientific article

Evaluation of Gut-Blood Barrier (GBB) dysfunction in various models of trauma, haemorrhagic shock and burn injury

scientific article

Experimental blunt chest trauma-induced myocardial inflammation and alteration of gap-junction protein connexin 43.

scientific article published on 9 November 2017

Expression and function of the C5a receptor in rat alveolar epithelial cells

scientific journal article

Extracellular Vesicles: Packages Sent With Complement

scientific article published on 11 April 2018

Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a.

scientific article published on 3 February 2012

Functional immune monitoring in severely injured patients-A pilot study

scientific article published on 03 November 2019

Functional roles for C5a receptors in sepsis

scientific article published on 04 May 2008

Functions of the complement components C3 and C5 during sepsis

scientific article published on 27 June 2008

Generation of C5a by phagocytic cells

scientific article published on November 2002

Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands

scientific article

Granzyme B: a new crossroad of complement and apoptosis

scientific article published on January 2012

Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

scientific article published on 16 November 2017

How do German medical students perceive role models during clinical placements ("Famulatur")? An empirical study.

scientific article

How many general and inflammatory variables need to be fulfilled when defining sepsis due to the 2003 SCCM/ESICM/ACCP/ATS/SIS definitions in critically ill surgical patients: a retrospective observational study ⬇️

scientific article published on December 21, 2010

How to treat esophageal perforations when determinants and predictors of mortality are considered

scientific article

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells

scientific article

Hypercapnic Conditions After Experimental Blunt Chest Trauma Increase Efferocytosis of Alveolar Macrophages and Reduce Local Inflammation

scientific article

Hyperoxia in Septic Shock: Crafty Therapeutic Weapon or Double-Edged Sword?

scientific article published in October 2017

IKK2/NF-κB signaling protects neurons after traumatic brain injury

scientific article published on 29 November 2017

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration

scientific article published on December 2015

Immunodesign of experimental sepsis by cecal ligation and puncture

scientific article published on January 2009

Immunopathophysiology of trauma-related acute kidney injury

scientific article published on 21 September 2020

Immunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest trauma.

scientific article

In-Depth Characterization of the Effects of Cigarette Smoke Exposure on the Acute Trauma Response and Hemorrhage in Mice

scientific article published on 8 February 2018

Inflammatory Effects of Hypothermia and Inhaled H2S During Resuscitated, Hyperdynamic Murine Septic Shock ⬇️

scientific article published on April 1, 2011

Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice: distinct early response compared with single trauma or "double-hit" injury

scientific article

Inhaled Hydrogen Sulfide Induces Suspended Animation, But Does Not Alter the Inflammatory Response After Blunt Chest Trauma ⬇️

scientific article published on February 1, 2012

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

scientific article published on 06 February 2009

Innate immune responses to trauma

scientific article published on 5 March 2018

Interaction between the coagulation and complement system

scientific article published on January 2008

Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

scientific article published on 06 June 2016

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses

scientific article published on 9 October 2017

Medusa's Head: The Complement System in Traumatic Brain and Spinal Cord Injury

scientific article

Mesenchymal Stem Cells after Polytrauma: Actor and Target

scientific article

Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release

scientific article

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F. Osuchowski et al published 14 August 2018 in Infection

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Modeling traumatic-hemorrhagic shock--nothing is simple and easy

scientific article

Molecular events in the cardiomyopathy of sepsis

scientific article published on May 2008

Molecular intercommunication between the complement and coagulation systems

scientific article

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"? ⬇️

scientific article published on November 30, 2011

Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses

scientific article published on 4 January 2018

Neutrophil heterogeneity and its role in infectious complications after severe trauma.

scientific article

Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin.

scientific article

New Insights into the Role of Peroxisome Proliferator-Activated Receptors in Regulating the Inflammatory Response after Tissue Injury ⬇️

scientific article published on February 29, 2012

New insights of an old defense system: structure, function, and clinical relevance of the complement system

scientific article

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

scientific article

Oxygen in the Heart: How Much is too Much?

scientific article published on 5 October 2016

Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system

scientific article published on 5 October 2013

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma.

scientific article

Pathophysiology of septic encephalopathy--an unsolved puzzle

scientific article

Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock ⬇️

scientific article published on January 12, 2011

Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma

scientific article

Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock

Pyrosequencing-based strategy for a successful SNP detection in two hypervariable regions: HV-I/HV-II of the human mitochondrial displacement loop

scientific article published in January 2010

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

scientific article published on 14 July 2006

Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?

scientific article published on 24 August 2017

Relationship of acute lung inflammatory injury to Fas/FasL system

scientific article

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo

scientific article published on 18 September 2017

Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI).

scientific article

Role of Complement in Multiorgan Failure ⬇️

scientific article published on December 20, 2012

Role of Complement on Broken Surfaces After Trauma

scientific article published on January 2015

Role of Hemorrhagic Shock in Experimental Polytrauma

scientific article published on 13 June 2017

Role of alveolar macrophages in the inflammatory response after trauma

scientific article published on July 2014

Role of extracellular histones in the cardiomyopathy of sepsis.

scientific article published on 13 February 2015

Role of the Purinergic Receptor P2XR4 After Blunt Chest Trauma in Cigarette Smoke-Exposed Mice

scientific article published on 24 August 2016

Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients

scientific article

Sepsis-Induced Adipokine Change with regard to Insulin Resistance ⬇️

scientific article published on 09 January 2012

Structure-function relationships of human C5a and C5aR.

scientific article

Systemic recovery and therapeutic effects of transplanted allogenic and xenogenic mesenchymal stromal cells in a rat blunt chest trauma model

scientific article published on 6 December 2017

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

scientific article published on 22 November 2018

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

Temperature and cell-type dependency of sulfide effects on mitochondrial respiration

scientific article

The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.

scientific article published in April 2019

The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice

scientific article published on 28 September 2016

The Role of Troponin in Blunt Cardiac Injury After Multiple Trauma in Humans

scientific article published on 8 August 2016

The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro

scientific article

The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis

scientific journal article

The dual role of academic surgeons as clinicians and researchers - an attempt to square the circle?

scientific article

The immune response after fracture trauma is different in old compared to young patients

scientific article

The impact of a dedicated training program for oral examiners at a medical school in Germany: a survey among participants from operative and non-operative disciplines ⬇️

scientific article published on 03 July 2013

The molecular fingerprint of lung inflammation after blunt chest trauma

scientific article

The neuroprotective effect of ethanol intoxication in TBI is associated with the suppression of ErbB signaling in PV-positive interneurons

scientific article

The obesity paradox revisited: does increased body mass protect against circulatory shock?

scientific article

The role of complement in bone healing: Fracture healing in C3 and C5-deficient mice

scholarly article by Christian M. Ehrnthaller et al published November 2012 in Immunobiology

The role of complement in trauma and fracture healing

scientific article published on February 2013

The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome

scientific article published on July 2006

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure

Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis

scientific article published on 10 January 2020

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

scientific article published on 23 January 2017

Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response

scientific article published on 12 February 2009

Visions and reality: the idea of competence-oriented assessment for German medical students is not yet realised in licensing examinations

scientific article

Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system ⬇️

scientific article published on 05 April 2013

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