List of works - Petr Dzubak

2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.

scientific article

7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.

scientific article published on 27 January 2016

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

scientific article

Aurora kinase inhibitors: progress towards the clinic

scientific article published on 18 February 2012

Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins

scientific article published on 17 November 2018

Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs.

scientific article

Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells

scientific article published on 2 April 2015

Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs

scientific article published on 22 November 2012

Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models.

scientific article

Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells.

scientific article

Correction to "Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides"

scientific article published on 25 January 2019

Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives

scientific article

Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.

scientific article published on 11 April 2012

Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes

scientific article published on 28 January 2016

Estradiol dimer inhibits tubulin polymerization and microtubule dynamics

scientific article published on 24 May 2018

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

scientific article published on 07 March 2017

Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors

scientific article published on 21 February 2020

Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells.

scientific article published on 17 May 2016

Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites

scientific article published on 31 January 2019

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX

scientific article published on 16 October 2019

Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease

scientific article

N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II.

scientific article published on 11 January 2018

New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity.

scientific article published on 8 February 2006

Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.

scientific article published on 25 April 2017

Pharmacological activities of natural triterpenoids and their therapeutic implications.

scientific article published on 3 May 2006

Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin.

scientific article published on 5 November 2015

Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry.

scientific article published in August 2005

Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells.

scientific article published on 3 May 2017

Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation

scientific article published on 25 May 2016

Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response

scientific article published on 29 August 2016

Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization

scientific article

Sugar modified pyrimido[4,5-]indole nucleosides: synthesis and antiviral activity

scientific article published on 25 August 2017

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

scientific article published on 18 May 2020

Synthesis and Biological Profiling of Pyrazolo-fused 7-Deazapurine Nucleosides

scientific article published on 21 July 2020

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.

scientific article published on 21 February 2017

Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid

scientific article published on 13 January 2017

Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides

scientific article published on 10 April 2020

Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides

scientific article published on 3 October 2018

Synthesis and biological activity evaluation of hydrazone derivatives based on a Tröger’s base skeleton

scientific article published on 23 January 2015

Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties

scientific article published on 29 July 2019

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

scientific article published on 31 October 2015

Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells.

scientific article published on April 2015

Synthesis, Photophysical Properties and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides

scientific article published on 20 May 2020

Synthetic approach for rapid preparation of BODIPY conjugates and their use in imaging of cellular drug uptake and distribution.

scientific article published on 7 February 2018

TLR 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates

scientific article published on 29 August 2017

The dual role of asporin in breast cancer progression

scientific article published on 07 July 2016

The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the "classical" cytokinin ribosides

scientific article

Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity.

scientific article published on 17 August 2016

Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM.

scientific article published on 9 February 2018

Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin.

scientific article published on 14 April 2017

[Tumor cells transfer between the patient and laboratory animal as a basic methodological approach to the study of cancerogenesis and identification of biomarkers]

List of works by Petr Dzubak

2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.

7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Aurora kinase inhibitors: progress towards the clinic

Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins

Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs.

Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells

Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs

Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models.

Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells.

Correction to "Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides"

Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives

Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.

Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes

Estradiol dimer inhibits tubulin polymerization and microtubule dynamics

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors

Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells.

Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX

Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease

N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II.

New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity.

Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.

Pharmacological activities of natural triterpenoids and their therapeutic implications.

Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin.

Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry.

Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells.

Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation

Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response

Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization

Sugar modified pyrimido[4,5-]indole nucleosides: synthesis and antiviral activity

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

Synthesis and Biological Profiling of Pyrazolo-fused 7-Deazapurine Nucleosides

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.

Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid

Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides

Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides

Synthesis and biological activity evaluation of hydrazone derivatives based on a Tröger’s base skeleton

Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells.

Synthesis, Photophysical Properties and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides

Synthetic approach for rapid preparation of BODIPY conjugates and their use in imaging of cellular drug uptake and distribution.

TLR 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates

The dual role of asporin in breast cancer progression

The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the "classical" cytokinin ribosides

Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity.

Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM.

Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin.

[Tumor cells transfer between the patient and laboratory animal as a basic methodological approach to the study of cancerogenesis and identification of biomarkers]