List of works - Robert J Lucas

'In a dark place, we find ourselves': light intensity in critical care units.

scientific article published on 7 February 2017

2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo.

scientific article published on April 2007

A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.

scientific article

A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling.

scientific article published on 16 January 2018

Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay.

scientific article

Addition of human melanopsin renders mammalian cells photoresponsive

scientific article

An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor

scientific article published on 23 February 2018

Cartilage repair using human embryonic stem cell-derived chondroprogenitors

scientific article

Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

scientific article published in 2021

Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice

scientific article published on 13 July 2016

Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram.

scientific article published in November 2016

Chromatic clocks: Color opponency in non-image-forming visual function.

scientific article

Circadian clocks: A cry in the dark?

scientific article published in November 1999

Circadian oscillation of photopigment transcript levels in the mouse retina.

scientific article published in September 1999

Clocks, criteria and critical genes

scientific article published on 01 July 1999

Colour as a signal for entraining the mammalian circadian clock

scientific article

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight

scientific article published on 01 December 2019

Convergence of visual and whisker responses in the primary somatosensory thalamus (ventral posterior medial region) of the mouse

scientific article published on 08 August 2016

Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish.

scientific article published on 23 May 2018

Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina

scientific journal article

Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.

scientific article

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

scientific article

Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice.

scientific article

Encephalic photoreception and phototactic response in the troglobiont Somalian blind cavefish Phreatichthys andruzzii.

scientific article

Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans.

scientific article published on 26 September 2017

Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates

scientific article

Expression of opsin genes early in ocular development of humans and mice.

scientific article

Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamster.

scientific article

Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment

scientific article published on 22 October 2019

Form vision from melanopsin in humans

scientific article published on 22 May 2019

Free running circadian rhythms of melatonin, luteinizing hormone, and cortisol in Syrian hamsters bearing the circadian tau mutation

scientific article published on 01 February 1999

Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.

scientific article

How rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock

scientific article published on January 2012

How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments

scientific article published on 26 June 2019

Human melanopsin forms a pigment maximally sensitive to blue light (λmax ≈ 479 nm) supporting activation of G(q/11) and G(i/o) signalling cascades

scientific article

Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.

scientific article

Influence of the rod photoresponse on light adaptation and circadian rhythmicity in the cone ERG.

scientific article published on 30 October 2009

Light, endocrine systems, and cancer--a view from circadian biologists

scientific article published on 01 July 2002

Mammalian Inner Retinal Photoreception ⬇️

scientific article published on February 4, 2013

Measuring vision using innate behaviours in mice with intact and impaired retina function

scientific article published on 17 July 2019

Melanopsin Contributions to the Representation of Images in the Early Visual System

scientific article

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

scientific article

Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision

scientific article

Melanopsin regulates visual processing in the mouse retina.

scientific article published in February 2006

Melanopsin supports irradiance-driven changes in maintained activity in the superior colliculus of the mouse

scientific article published on 16 July 2016

Melanopsin-Based Brightness Discrimination in Mice and Humans ⬇️

scientific article published on May 24, 2012

Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina.

scientific article

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn

scientific article

Melanopsin-driven light adaptation in mouse vision

scientific article published on 9 October 2014

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

scientific article published in January 2017

Multiple hypothalamic cell populations encoding distinct visual information.

scientific article published on 10 January 2011

Multiplexing Visual Signals in the Suprachiasmatic Nuclei.

scientific article published in November 2017

Neural reprogramming in retinal degeneration.

scientific article published on July 2007

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue

scientific article (publication date: 20 November 2003)

Non-rod, non-cone photoreception in rodents and teleost fish.

scientific article published on January 2003

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator.

scientific article

Persistence of masking responses to light in mice lacking rods and cones.

scientific article published in December 2001

Photoreceptive retinal ganglion cells control the information rate of the optic nerve

article published in the Proceedings of the National Academy of Sciences of the United States of America

Postnatal growth rate and gonadal development in circadian tau mutant hamsters reared in constant dim red light

scientific article published on 01 March 2000

Pupil responses to hidden photoreceptor-specific modulations in movies

article

Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.

scientific article

Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.

scientific article

Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool

scientific article

Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.

scientific article

Responses to Spatial Contrast in the Mouse Suprachiasmatic Nuclei

scientific article published on 11 May 2017

Restoration of Vision with Ectopic Expression of Human Rod Opsin

scientific article published on 28 July 2015

Retinal output changes qualitatively with every change in ambient illuminance

scientific article

Rods progressively escape saturation to drive visual responses in daylight conditions.

scientific article published on 27 November 2017

Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones.

scientific article

Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development

scientific article (publication date: 15 July 2001)

The electroretinogram as a method for studying circadian rhythms in the mammalian retina.

scientific article published on December 2008

The impact of temporal modulations in irradiance under light adapted conditions on the mouse suprachiasmatic nuclei (SCN).

scientific article

The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions

scientific article

The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment.

scientific article published on February 2002

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

scientific article published in January 2016

Visual responses in mice lacking critical components of all known retinal phototransduction cascades

scientific article

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.

scientific article published on 13 August 2010

List of works by Robert J Lucas

'In a dark place, we find ourselves': light intensity in critical care units.

2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo.

A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.

A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling.

Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay.

Addition of human melanopsin renders mammalian cells photoresponsive

An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor

Cartilage repair using human embryonic stem cell-derived chondroprogenitors

Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice

Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram.

Chromatic clocks: Color opponency in non-image-forming visual function.

Circadian clocks: A cry in the dark?

Circadian oscillation of photopigment transcript levels in the mouse retina.

Clocks, criteria and critical genes

Colour as a signal for entraining the mammalian circadian clock

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight

Convergence of visual and whisker responses in the primary somatosensory thalamus (ventral posterior medial region) of the mouse

Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish.

Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina

Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice.

Encephalic photoreception and phototactic response in the troglobiont Somalian blind cavefish Phreatichthys andruzzii.

Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans.

Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates

Expression of opsin genes early in ocular development of humans and mice.

Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamster.

Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment

Form vision from melanopsin in humans

Free running circadian rhythms of melatonin, luteinizing hormone, and cortisol in Syrian hamsters bearing the circadian tau mutation

Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.

How rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock

How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments

Human melanopsin forms a pigment maximally sensitive to blue light (λmax ≈ 479 nm) supporting activation of G(q/11) and G(i/o) signalling cascades

Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.

Influence of the rod photoresponse on light adaptation and circadian rhythmicity in the cone ERG.

Light, endocrine systems, and cancer--a view from circadian biologists

Mammalian Inner Retinal Photoreception ⬇️

Measuring vision using innate behaviours in mice with intact and impaired retina function

Melanopsin Contributions to the Representation of Images in the Early Visual System

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision

Melanopsin regulates visual processing in the mouse retina.

Melanopsin supports irradiance-driven changes in maintained activity in the superior colliculus of the mouse

Melanopsin-Based Brightness Discrimination in Mice and Humans ⬇️

Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina.

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn

Melanopsin-driven light adaptation in mouse vision

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

Multiple hypothalamic cell populations encoding distinct visual information.

Multiplexing Visual Signals in the Suprachiasmatic Nuclei.

Neural reprogramming in retinal degeneration.

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue

Non-rod, non-cone photoreception in rodents and teleost fish.

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator.

Persistence of masking responses to light in mice lacking rods and cones.

Photoreceptive retinal ganglion cells control the information rate of the optic nerve

Postnatal growth rate and gonadal development in circadian tau mutant hamsters reared in constant dim red light

Pupil responses to hidden photoreceptor-specific modulations in movies

Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.

Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.

Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool

Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.

Responses to Spatial Contrast in the Mouse Suprachiasmatic Nuclei

Restoration of Vision with Ectopic Expression of Human Rod Opsin

Retinal output changes qualitatively with every change in ambient illuminance

Rods progressively escape saturation to drive visual responses in daylight conditions.

Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones.

Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development

The electroretinogram as a method for studying circadian rhythms in the mammalian retina.

The impact of temporal modulations in irradiance under light adapted conditions on the mouse suprachiasmatic nuclei (SCN).

The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions

The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment.

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

Visual responses in mice lacking critical components of all known retinal phototransduction cascades

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.