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List of works by Lauren M Aleksunes

Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes.

scientific article published on 08 May 2008

Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor

scientific article

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

scientific article published in PLoS ONE

Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain

scientific article

Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).

scientific article published on 11 October 2013

Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers

scientific article

Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

scientific article published on 29 July 2016

Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.

scientific article

Brain region-specific regulation of histone acetylation and efflux transporters in mice

scientific article published on 21 March 2019

Cefoxitin Plasma and Subcutaneous Adipose Tissue Concentration in Patients Undergoing Sleeve Gastrectomy

scientific article published on 11 December 2015

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

scientific article published on 30 April 2009

Constitutive activation of nuclear factor‐E2‐related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte‐specific deletion of Kelch‐like ECH‐associated protein 1 ⬇️

scientific article published on 02 May 2011

Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice

scientific article published on 05 February 2009

Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice ⬇️

scientific article published on April 11, 2012

Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

scientific article published on 21 September 2005

Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

scientific article published on 09 July 2008

Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers

scientific article published on 05 February 2016

Correlation between genotype and phenotypic categorization of staphylococci based on methicillin susceptibility and resistance

scientific article

Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates

scientific article published on 29 October 2018

Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice

scientific article published on 2 September 2014

Down-regulation of the placental BCRP/ABCG2 transporter in response to hypoxia signaling.

scientific article

Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.

scientific article published on 12 January 2008

Effects of developmental deltamethrin exposure on white adipose tissue gene expression

scientific article

Efflux Transporters Regulate Arsenite Induced Genotoxicity in Double Negative and Double Positive T Cells.

scientific article

Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease

scientific article published on 19 July 2007

Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells

scientific article

Establishment of metabolism and transport pathways in the rodent and human fetal liver.

scientific article published on 06 December 2013

Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting

scientific article published on 6 May 2016

Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs

scientific article published on 21 December 2011

Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals

scientific article published in 2022

Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.

scientific article

Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats.

scientific article published in March 2008

Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity ⬇️

scientific article published on April 11, 2012

Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter

scientific article published on 5 February 2016

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

scientific article published on 19 June 2015

Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium

scientific article published on 27 April 2015

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

scientific article

In Vitro Screening of Environmental Chemicals Identifies Zearalenone as a Novel Substrate of the Placental BCRP/ABCG2 Transporter

scientific article published on May 2015

In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants.

scientific article published on 12 April 2017

Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling

scientific article published on 08 April 2019

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

scientific article

Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases

scientific article published on 12 July 2007

Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in Microglia ⬇️

scientific article published on August 31, 2012

Inherited disorders of bilirubin clearance

scientific article

Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.

scientific article

Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter

scientific article (publication date: 2015)

Interindividual regulation of the BCRP/ABCG2 transporter in term human placentas

scientific article published on 31 January 2018

Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.

scientific article

Low Oxygen Tension Differentially Regulates the Expression of Placental Solute Carriers and ABC Transporters

scientific article published on 26 September 2020

MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells.

scientific article

Management of rosiglitazone-induced edema: two case reports and a review of the literature.

scientific article

Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver ⬇️

scientific article published on November 23, 2012

NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.

scientific article

Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1)

scientific article

Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

scientific article published on 29 August 2008

Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

scientific article

Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

scientific article published on January 2006

Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin.

scientific article

Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients

scientific article published on 15 September 2018

Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier.

scientific article published on 9 November 2017

Pregnancy Represses Induction of Efflux Transporters in Livers of Type I Diabetic Mice ⬇️

scientific article published on January 15, 2013

Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity.

scientific article published on 21 December 2016

Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.

scientific article published on 19 June 2008

Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase

scientific article published on 15 September 2018

Regional expression of the BCRP/ABCG2 transporter in term human placentas

scientific article

Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation

scientific article (publication date: 2016)

Regulation of hepatic phase II metabolism in pregnant mice

scientific article

Regulation of the placental BCRP transporter by PPAR gamma

scientific article

Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis

scientific article published on 26 October 2006

Renal efflux transporter expression in pregnant mice with Type I diabetes

scientific article

Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment

scientific article published on 02 July 2008

Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.

scientific article

Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064.

scientific article published on 5 September 2016

Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.

scientific article published on 19 November 2006

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.

scientific article published on 04 June 2009

Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).

scientific article published on 24 July 2015

Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium

scientific article published on 14 February 2016

Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice ⬇️

scientific article published on April 23, 2012

The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.

scientific article

The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis.

scientific article published on 30 December 2011

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

scientific article

Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.

scientific article published on 15 March 2014

Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy.

scientific article published in January 2017

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

scientific article

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