List of works - Damian C Crowther

20 years of GPnotebook: from a medical student project to a national resource

scientific article published on February 2014

A Drosophila model of Alzheimer's disease

scientific article published in January 2006

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

scientific article published on 23 September 2011

ANS binding reveals common features of cytotoxic amyloid species

scientific article published in August 2010

Alzheimer's disease: insights from Drosophila melanogaster models

scientific article

CCT complex restricts neuropathogenic protein aggregation via autophagy

scientific article published on 8 December 2016

Central and peripheral circadian clocks and their role in Alzheimer's disease.

scientific article published in October 2017

Characterisation of serpin polymers in vitro and in vivo.

scientific article

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

scientific article published on 15 February 2013

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

scientific article published on 18 February 2011

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development inDrosophila melanogaster ⬇️

scientific article published on September 29, 2011

Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease

scientific article published in January 2016

Endoplasmic reticulum dysfunction in neurological disease

scientific article published on January 2013

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins

scientific article

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity

scientific article

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems

scientific article published on 14 April 2016

Familial conformational diseases and dementias

scientific article

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

scientific article

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model

scientific article

Functional genomics in Drosophila models of human disease ⬇️

scientific article published on August 22, 2012

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

scientific article

Insights into amyloid disease from fly models.

scientific article

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

scientific article

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model

scientific article published on 23 April 2015

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

scientific article

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

scientific article published on 21 June 2021

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity

scientific article (publication date: May 2016)

Methods and models in neurodegenerative and systemic protein aggregation diseases

scientific article published on January 2010

Modeling serpin conformational diseases in Drosophila melanogaster

scientific article published in January 2011

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

scientific article (publication date: 10 May 2002)

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB

scientific article

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease

scientific article

Nucleation of alpha 1-antichymotrypsin polymerization

scientific article published in March 2003

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

scientific article

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival

scientific article published in June 2012

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies

scientific article published in September 2004

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies

scientific article published on March 2004

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease

scientific article published on 10 June 2018

Prion-induced toxicity in PrP transgenic Drosophila ⬇️

scientific article published on January 31, 2012

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

scientific article published on 12 September 2016

Protein misfolding and disease: from the test tube to the organism

scientific article

Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment

scientific article

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo

scientific article

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

scientific article published on 28 June 2013

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis

scientific article published on June 2006

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

scientific article

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

scientific article

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

scientific article published on 30 August 2017

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease

scientific article published on 13 October 2011

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

scientific article

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease

scientific article published on 26 February 2014

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

scientific article

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

scientific article published on 23 June 2011

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

scientific article published on 11 February 2008

The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

scientific article

Therapeutic targets from a Drosophila model of Alzheimer's disease

scientific article published in October 2004

Unravelling the twists and turns of the serpinopathies.

scientific article published on 20 June 2011

Using a Drosophila model of Alzheimer's disease.

scientific article published on January 2008

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

scientific article published on 22 September 2018

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

scientific article published on 14 May 2009

p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress

scientific article published on 22 January 2013

List of works by Damian C Crowther

20 years of GPnotebook: from a medical student project to a national resource

A Drosophila model of Alzheimer's disease

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

ANS binding reveals common features of cytotoxic amyloid species

Alzheimer's disease: insights from Drosophila melanogaster models

CCT complex restricts neuropathogenic protein aggregation via autophagy

Central and peripheral circadian clocks and their role in Alzheimer's disease.

Characterisation of serpin polymers in vitro and in vivo.

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development inDrosophila melanogaster ⬇️

Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease

Endoplasmic reticulum dysfunction in neurological disease

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems

Familial conformational diseases and dementias

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model

Functional genomics in Drosophila models of human disease ⬇️

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

Insights into amyloid disease from fly models.

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity

Methods and models in neurodegenerative and systemic protein aggregation diseases

Modeling serpin conformational diseases in Drosophila melanogaster

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease

Nucleation of alpha 1-antichymotrypsin polymerization

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease

Prion-induced toxicity in PrP transgenic Drosophila ⬇️

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Protein misfolding and disease: from the test tube to the organism

Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

Therapeutic targets from a Drosophila model of Alzheimer's disease

Unravelling the twists and turns of the serpinopathies.

Using a Drosophila model of Alzheimer's disease.

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress