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List of works by Alberto C Costa

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

scientific article published on 15 August 2007

An assessment of optokinetic nystagmus (OKN) in persons with Down syndrome.

scientific article published on 14 August 2011

An assessment of the vestibulo-ocular reflex (VOR) in persons with Down syndrome ⬇️

scientific article published on August 13, 2011

Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial ⬇️

scientific article published on July 17, 2012

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).

scientific article

Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

scientific article

Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference

scientific article

Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance

scientific article published on 28 October 2008

Down syndrome and genetics - a case of linked histories.

scientific article

Dynamics of the actions of tetrahydro-9-aminoacridine and 9-aminoacridine on glutamatergic currents: concentration-jump studies in cultured rat hippocampal neurons

scientific article published on 01 January 1994

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

scientific article published on 18 November 2011

Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome.

scientific article

Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

scientific article

Functional Properties of the Nicotinic and Glutamatergic Receptors ⬇️

scientific article published on January 1, 1991

G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses.

scientific article published in August 2005

Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome

scientific article published on 01 September 2004

Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down Syndrome

scientific article published on 28 March 2017

Genetic analysis of Down syndrome-associated heart defects in mice.

scientific article published on 26 March 2011

Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection

scientific article

Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome.

scientific article published in May 2006

Improved technique for studying ion channels expressed in Xenopus oocytes, including fast superfusion.

scientific article

Intracellular chloride accumulation: a possible mechanism for cognitive deficits in Down syndrome.

scientific article

Machine Learning Methods Predict Locomotor Response to MK-801 in Mouse Models of Down Syndrome ⬇️

scientific article published on March 10, 2011

Molecular effects of dimethylanatoxin on the peripheral nicotinic acetylcholine receptor

scientific article published on 01 February 1990

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

scientific article published on October 2008

Motor dysfunction in a mouse model for Down syndrome.

scientific article published in December 1999

Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study

scientific article published on 01 June 2020

On the Design of Broad-Based Neuropsychological Test Batteries to Assess the Cognitive Abilities of Individuals with Down Syndrome in the Context of Clinical Trials

scientific article published on 26 November 2018

On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome ⬇️

scientific article published on September 2, 2011

Pharmacokinetic Properties of Memantine after a Single Intraperitoneal Administration and Multiple Oral Doses in Euploid Mice and in the Ts65Dn Mouse Model of Down's Syndrome.

scientific article published on 30 May 2017

Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome.

scientific article

Prospects for Improving Brain Function in Individuals with Down Syndrome ⬇️

scientific article published on September 1, 2013

Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome

scientific article

Protein profiles associated with context fear conditioning and their modulation by memantine

scientific article published on 27 January 2014

Report and abstracts of the ninth international workshop on the molecular biology of human chromosome 21 and Down syndrome. Bar Harbor, Maine, USA. 23-26 September 2000

scientific article published on 01 January 2001

Soluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease

scientific article published on 3 March 2016

Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5

scientific article

The glutamatergic hypothesis for Down syndrome: the potential use of N-methyl-D-aspartate receptor antagonists to enhance cognition and decelerate neurodegeneration

scientific article published on February 2014

Ultrasonic vocalizations during male-female interaction in the mouse model of Down syndrome Ts65Dn.

scientific article published on 15 February 2014

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