List of works - Kaori Ishikawa

A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy.

scientific article published on 26 January 2017

A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.

scientific article published on 10 June 2015

Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior

scientific article published on 03 January 2019

An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats

scientific article

Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.

scientific article published in July 2005

Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats ⬇️

scientific article published on October 1, 2012

Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

scientific article published on 04 March 2019

Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.

scientific article published on 9 September 2017

Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders

scientific article published on 05 November 2019

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects.

scientific article published on 22 May 2015

G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.

scientific article published on 23 February 2015

Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes.

scientific article

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.

scientific article published on 31 January 2006

Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells.

scientific article published on 3 August 2010

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

scientific article

Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism

scientific article published on 04 July 2018

Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.

scientific article

Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.

scientific article published on 14 September 2015

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.

scientific article published on 11 April 2016

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

scientific article

Regulation of metastasis; mitochondrial DNA mutations have appeared on stage ⬇️

scientific article published on December 1, 2012

Reversible regulation of metastasis by ROS-generating mtDNA mutations.

scientific article published on 08 August 2008

Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system

scientific article

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.

scientific article published on 13 April 2006

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

scientific article

Trading mtDNA uncovers its role in metastasis.

scientific article published on 21 January 2009

Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders

scientific article published on 12 December 2014

Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model.

scientific article published on 23 March 2018

List of works by Kaori Ishikawa

A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy.

A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.

Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior

An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats

Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.

Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats ⬇️

Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.

Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects.

G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.

Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes.

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.

Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells.

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism

Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.

Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

Regulation of metastasis; mitochondrial DNA mutations have appeared on stage ⬇️

Reversible regulation of metastasis by ROS-generating mtDNA mutations.

Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

Trading mtDNA uncovers its role in metastasis.

Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders

Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model.