List of works - Carlos J Orihuela

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis

scientific article published on 21 September 2004

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

scientific article

Microarray analysis of pneumococcal gene expression during invasive disease

scientific article published on October 2004

The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms

scientific article (publication date: 2010)

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease

scientific article

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

article

The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells

scientific article published on 14 July 2009

Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia

scientific article

beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae

scientific article

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

scientific article published on December 11, 2015

Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production

scientific article

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

scientific article

Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge

scientific article

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function

scientific article

Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization

scientific article published on 15 October 2013

Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.

scientific article published in November 2006

Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans

scientific article published in 2005

A role for glycosylated serine‐rich repeat proteins in Gram‐positive bacterial pathogenesis

scientific article published on June 11, 2012

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

scientific article

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

scientific article

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

scientific article

Organ-specific models of Streptococcus pneumoniae disease

scientific article published in January 2003

Incidence of cardiovascular events after hospital admission for pneumonia.

scientific article

Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma

scientific article published on 20 August 2009

Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae

scientific article

Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence

scientific article (publication date: 2011)

Cell wall-mediated neuronal damage in early sepsis

scientific article

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis

scientific article

Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

scientific article

Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia

scientific article

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

scientific article published on 14 June 2017

Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization

scientific article

Pneumococci: immunology of the innate host response.

scientific article published on 20 July 2010

Dysregulated inflammation as a risk factor for pneumonia in the elderly

scientific article published on December 1, 2011

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

scientific article published on 29 February 2016

Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix.

scientific article published on 27 April 2010

Pneumococcal gene complex involved in resistance to extracellular oxidative stress

scientific article published on 3 January 2012

NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

scientific article published on 01 July 2018

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

scientific article

Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

scientific article published on January 7, 2015

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.

scientific article published on August 2016

Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia

scientific article

Future research directions in pneumonia: NHLBI working group report

journal article published in 2018

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

scientific article published on 25 August 2017

Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model.

scientific article published in April 2005

PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type

scientific article

Cardiotoxicity during invasive pneumococcal disease

scientific article

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

scientific article published on 17 January 2014

Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

scientific article

A Non-Human Primate Model of Severe Pneumococcal Pneumonia

scientific article

List of works by Carlos J Orihuela

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

Microarray analysis of pneumococcal gene expression during invasive disease

The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells

Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia

beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function

Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization

Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.

Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans

A role for glycosylated serine‐rich repeat proteins in Gram‐positive bacterial pathogenesis

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

Organ-specific models of Streptococcus pneumoniae disease

Incidence of cardiovascular events after hospital admission for pneumonia.

Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma

Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae

Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence

Cell wall-mediated neuronal damage in early sepsis

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis

Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization

Pneumococci: immunology of the innate host response.

Dysregulated inflammation as a risk factor for pneumonia in the elderly

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix.

Pneumococcal gene complex involved in resistance to extracellular oxidative stress

NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.

Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia

Future research directions in pneumonia: NHLBI working group report

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model.

PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type

Cardiotoxicity during invasive pneumococcal disease

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

A Non-Human Primate Model of Severe Pneumococcal Pneumonia