List of works - Ian Dransfield

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

scientific article published on 19 August 2019

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

scientific article published on 23 December 2016

A blast from the past: clearance of apoptotic cells regulates immune responses.

scientific article

A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.

scientific article published on 8 March 2004

A cut above the rest?

scientific article published on 01 April 2002

Activation of human lung mast cells by monomeric immunoglobulin E

scientific article published on 01 October 2005

Activation of neutrophil function via CD66: differential effects upon β 2 integrin mediated adhesion

scientific article published on 01 September 1997

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

scientific article published on 01 December 1995

Analysis of neutrophil apoptosis.

scientific article published in January 2007

Apoptotic Tumor Cell-Derived Extracellular Vesicles as Important Regulators of the Onco-Regenerative Niche.

scientific article

Assessment of neutrophil apoptosis.

scientific article published in January 2014

Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity.

scientific article published in June 2009

Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?

scientific article

C-reactive protein does not opsonize early apoptotic human neutrophils, but binds only membrane-permeable late apoptotic cells and has no effect on their phagocytosis by macrophages

scientific article

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages ⬇️

scientific article published on July 15, 1997

CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion

scientific article published on 01 July 1995

CD66: role in the regulation of neutrophil effector function

scientific article published on 01 December 1996

Characterization of a monoclonal antibody recognizing a novel leucocyte adhesion molecule

scientific article published on 01 April 1990

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.

scientific article

Choice of anticoagulant critically affects measurement of circulating platelet-leukocyte complexes.

scientific article

Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes

scientific article published on 29 June 2015

Clearance of apo Nph induces an immunosuppressive response in pro-inflammatory type-1 and anti-inflammatory type-2 MΦ

scientific article published on 01 May 2009

Clearance of dying cells and autoimmunity

scientific article published on June 2007

Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states

scientific article published on 01 March 1988

Constitutive neutrophil apoptosis in culture is modulated by cell density independently of β2 integrin-mediated adhesion

article

Copy Number Variation of FCGR3B Is Associated with Susceptibility to Idiopathic Pulmonary Fibrosis

scientific article published in 2011

Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway.

scientific article

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

scientific article

Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi

scientific article published on 12 December 2002

Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions

scientific article published on 01 March 1988

Differential effects of bacterial lipopolysaccharides upon neutrophil function.

scientific article

Distribution of isoforms of the myofibrillar proteins in myoid cells of thymus

scientific article published on 01 August 1986

Divalent cation-dependent and -independent augmentation of macrophage phagocytosis of apoptotic neutrophils by CD44 antibody

scientific article published on 01 December 2004

Diversification of TAM receptor tyrosine kinase function

scientific article

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.

scientific article published on 2 March 2006

Early events of the immune response mediated by leukocyte integrins.

scientific article published on April 1990

Effects of glucocorticoids on apoptosis and clearance of apoptotic cells.

scientific article published on 17 August 2007

Electric fields and inflammation: may the force be with you.

scientific article

Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation.

scientific article

Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.

scientific article

Fetuin/α2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages ⬇️

scientific article published on September 1, 2003

Functional and clinical consequences of Fc receptor polymorphic and copy number variants.

scientific article published on August 2009

Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation.

scientific article

Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes

scientific article published on 01 March 1999

Granulocyte apoptosis and the control of inflammation.

scientific article published on August 1994

Granulocyte apoptosis: who would work with a 'real' inflammatory cell?

scientific article published on June 2004

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.

scientific article

Identification of a novel monocyte cell surface molecule involved in the generation of antigen-induced proliferative responses

article

Immune complexes bind preferentially to Fc gamma RIIA (CD32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cytokines

scientific article published in February 2004

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes

scientific article published on 01 September 1996

Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes

scientific article published on 01 May 2002

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.

scientific article

Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.

scientific article

Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis

scientific article published in February 2002

Inhibitory Fc RIIb and CD20 internalization

scientific article published on 01 January 2014

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function ⬇️

scientific article published on March 1, 1992

Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells.

scientific article published in June 2004

Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.

scientific article published in September 2005

LFA-1 and ICAM-1 in Homotypic Aggregation of Rat Alveolar Macrophages: Organic Dust-mediated Aggregation by a Non-Protein Kinase C-dependent Pathway

scientific article published on 01 August 1993

Leukocyte integrin activation

scientific article published on 01 March 1992

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

scientific article published on 29 October 2008

Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

scientific article published on 17 April 2020

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.

scientific article

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

scientific article published on 8 February 2018

Monocyte Functional Responsiveness After PSGL-1–Mediated Platelet Adhesion Is Dependent on Platelet Activation Status

scientific article published in August 2008

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

scientific article

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression

scientific article published on 01 August 1994

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation.

scientific article

Neutrophils: dead or effete? Cell surface phenotype and implications for phagocytic clearance

scientific article published on 01 November 2005

Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils

scientific article published on October 2016

Peritonitis activates transcription of the human prolactin locus in myeloid cells in a humanized transgenic rat model.

scientific article published on 11 April 2012

Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry.

scientific article

Phagocytosis of apoptotic cells.

scientific article published on March 2008

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.

scientific article

Priming differentially regulates neutrophil adhesion molecule expression/function

scientific article published on 01 September 1996

Recognition of apoptotic cells by phagocytes.

scientific article

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis

scientific article published on 01 June 1995

Regulation of granulocyte apoptosis by NF-kappaB.

scientific article published on June 2004

Regulation of granulocyte apoptosis by hemopoietic growth factors, cytokines and drugs: potential relevance to allergic inflammation.

scientific article published on December 2003

Regulation of leukocyte integrin function

scientific article published on January 1, 1991

Regulation of macrophage phagocytosis of apoptotic cells by cAMP

scientific article published on 01 April 1998

Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin

scientific article published on 01 November 1998

Regulation of neutrophil apoptosis and removal of apoptotic cells.

scientific article

Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro

scientific article published on 01 October 1997

Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites

scientific article published on 01 April 1998

Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites

scientific article published on 01 February 1998

Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis

scientific article

Role of selectiris In development of adult respiratory distress syndrome

article

Soluble E-selectin Acts in Synergy with Platelet-activating Factor to Activate Neutrophil β2-Integrins

scientific article published on 01 May 2000

Specific binding of an antigen-antibody complex to apoptotic human neutrophils

scientific article published on March 2003

Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype.

scientific article

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells

scientific article

Technical Advance: Autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production ⬇️

scientific article published on May 10, 2013

The "Phagocytic Synapse" and Clearance of Apoptotic Cells.

scientific article published on 4 December 2017

The importance of the macrophage within the human endometrium.

scientific article published on 29 October 2012

The uncoupling of monocyte-platelet interactions from the induction of proinflammatory signaling in monocytes.

scientific article published on 16 October 2013

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

scientific article published in Nature

You can lead a macrophage to an inflammatory site but can you make it eat?

scientific article

List of works by Ian Dransfield

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

A blast from the past: clearance of apoptotic cells regulates immune responses.

A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.

A cut above the rest?

Activation of human lung mast cells by monomeric immunoglobulin E

Activation of neutrophil function via CD66: differential effects upon β 2 integrin mediated adhesion

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

Analysis of neutrophil apoptosis.

Apoptotic Tumor Cell-Derived Extracellular Vesicles as Important Regulators of the Onco-Regenerative Niche.

Assessment of neutrophil apoptosis.

Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity.

Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?

C-reactive protein does not opsonize early apoptotic human neutrophils, but binds only membrane-permeable late apoptotic cells and has no effect on their phagocytosis by macrophages

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages ⬇️

CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion

CD66: role in the regulation of neutrophil effector function

Characterization of a monoclonal antibody recognizing a novel leucocyte adhesion molecule

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.

Choice of anticoagulant critically affects measurement of circulating platelet-leukocyte complexes.

Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes

Clearance of apo Nph induces an immunosuppressive response in pro-inflammatory type-1 and anti-inflammatory type-2 MΦ

Clearance of dying cells and autoimmunity

Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states

Constitutive neutrophil apoptosis in culture is modulated by cell density independently of β2 integrin-mediated adhesion

Copy Number Variation of FCGR3B Is Associated with Susceptibility to Idiopathic Pulmonary Fibrosis

Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway.

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi

Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions

Differential effects of bacterial lipopolysaccharides upon neutrophil function.

Distribution of isoforms of the myofibrillar proteins in myoid cells of thymus

Divalent cation-dependent and -independent augmentation of macrophage phagocytosis of apoptotic neutrophils by CD44 antibody

Diversification of TAM receptor tyrosine kinase function

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.

Early events of the immune response mediated by leukocyte integrins.

Effects of glucocorticoids on apoptosis and clearance of apoptotic cells.

Electric fields and inflammation: may the force be with you.

Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation.

Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.

Fetuin/α2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages ⬇️

Functional and clinical consequences of Fc receptor polymorphic and copy number variants.

Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation.

Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes

Granulocyte apoptosis and the control of inflammation.

Granulocyte apoptosis: who would work with a 'real' inflammatory cell?

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.

Identification of a novel monocyte cell surface molecule involved in the generation of antigen-induced proliferative responses

Immune complexes bind preferentially to Fc gamma RIIA (CD32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cytokines

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes

Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.

Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.

Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis

Inhibitory Fc RIIb and CD20 internalization

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function ⬇️

Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells.

Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.

LFA-1 and ICAM-1 in Homotypic Aggregation of Rat Alveolar Macrophages: Organic Dust-mediated Aggregation by a Non-Protein Kinase C-dependent Pathway

Leukocyte integrin activation

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

Monocyte Functional Responsiveness After PSGL-1–Mediated Platelet Adhesion Is Dependent on Platelet Activation Status

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation.

Neutrophils: dead or effete? Cell surface phenotype and implications for phagocytic clearance

Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils

Peritonitis activates transcription of the human prolactin locus in myeloid cells in a humanized transgenic rat model.

Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry.

Phagocytosis of apoptotic cells.

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.

Priming differentially regulates neutrophil adhesion molecule expression/function

Recognition of apoptotic cells by phagocytes.

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis

Regulation of granulocyte apoptosis by NF-kappaB.

Regulation of granulocyte apoptosis by hemopoietic growth factors, cytokines and drugs: potential relevance to allergic inflammation.