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List of works by Gloria Bonuccelli

A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX

scholarly article by Federica Sotgia published in September 2018

A novel mutation, Y103X, and exon skipping in a patient with Hunter disease

scientific article published on 01 April 2000

ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection

scientific article

Aberrant splicing at catalytic site as cause of infantile onset glycogen storage disease type II (GSDII): molecular identification of a novel IVS9 (+2GT-->GC) in combination with rare IVS10 (+1GT-->CT)

scientific article published on 01 June 2001

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

scientific article

CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway

scientific article

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

scientific article published on 10 September 2015

Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation

scientific article published on 22 December 2012

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature

scientific article published on May 2009

Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition

scientific article published on November 2011

Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation

scientific journal article

Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers

scientific article published on November 2006

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

scientific article published on March 2009

Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection

scientific article

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

scientific article

Evidence for a founder effect in Sicilian patients with glycogen storage disease type II

scientific article published on 01 November 2000

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

scientific article published on April 2009

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

scientific article published on 30 August 2008

Identification of a novel recombinant allele in three unrelated Italian Gaucher patients: implications for prognosis and genetic counseling

scientific article published on 01 August 2000

Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.

scientific article

Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells.

scientific article published on June 2002

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

scientific article

Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo

scientific article

Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice

scientific article published on 27 May 2007

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

scientific journal article

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways

article by Gloria Bonuccelli et al published 23 August 2018 in Aging

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

scientific article

Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

scientific article

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

scientific article published on 19 January 2018

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

scientific article published on 28 September 2015

Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast ⬇️

scientific article published on 7 July 2017

Molecular analysis of 40 Italian patients with mucopolysaccharidosis type II: New mutations in the iduronate-2-sulfatase (IDS) gene

scientific article published on 01 August 2001

NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting "stemness".

scientific article

Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment

scientific article

Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease

scientific article published on 2 July 2003

Phosphofructokinase muscle-specific isoform requires caveolin-3 expression for plasma membrane recruitment and caveolar targeting: implications for the pathogenesis of caveolin-related muscle diseases

scientific article published in December 2003

Prenatal diagnosis of Pelizaeus-Merzbacher disease: detection of proteolipid protein gene duplication by quantitative fluorescent multiplex PCR

scientific article published on 01 August 2001

Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins

scientific article published on October 2003

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells.

scientific article published on September 2014

Somatic mosaicism in a patient with Gaucher disease type 2: implication for genetic counseling and therapeutic decision-making

scientific article published on 01 December 2000

Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas

scientific article published on May 2013

Stat3 promotes metastatic progression of prostate cancer.

scientific article published on 15 May 2008

Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells

scientific article published on November 2006

Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

scientific article

Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy ⬇️

scientific article

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

scientific article

The effect of four mutations on the expression of iduronate-2-sulfatase in mucopolysaccharidosis type II

scientific article published on 01 November 2001

The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis

scientific article

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

scientific article

Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies

scientific article

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

scientific article published in June 2009

Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

scientific article

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion.

scientific article

Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation

scientific article

V-ATPase is a candidate therapeutic target for Ewing sarcoma

scientific article published on 8 April 2013

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

scientific article published on 9 June 2017

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