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List of works by Heikki Hyoty

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes

scientific article published on 18 November 2017

A T-helper cell epitope overlaps a major B-cell epitope in human papillomavirus type 18 E2 protein

scientific article published on 01 November 1992

A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates

scientific article published on 06 May 2020

A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

scientific article published on 8 January 2018

A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses

scientific article published on 09 November 2019

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.

scientific article published on 5 November 2014

A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group

scientific article published on 01 June 1995

Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia

scientific article published on 01 April 2007

An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children.

scientific article published on 25 July 2014

Analysis of pancreas tissue in a child positive for islet cell antibodies.

scientific article published on 12 August 2008

Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4. Childhood Diabetes in Finland Study Group

scientific article published on 01 June 1996

Antibody reactivity against thyroid peroxidase and myeloperoxidase in autoimmune thyroiditis and systemic vasculitis

scientific article published on 01 July 1997

Antibody reactivity to an Epstein-Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 beta chain. Childhood Diabetes in Finland Study Group.

scientific article

Antipeptide antibodies to adenovirus E1b protein indicate enhanced risk of celiac disease and dermatitis herpetiformis

scientific article published on 01 January 1993

Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

scientific article published on 14 October 2020

Can enteroviruses cause type 1 diabetes?

scientific article published in November 2003

Circulating myeloperoxidase may cause false negative findings in the analysis of myeloperoxidase antibodies in systemic vasculitis

scientific article published on 01 September 1994

Circulating vitamin D concentrations in two neighboring populations with markedly different incidence of type 1 diabetes

scientific article published on 01 June 2006

Cis-urocanic acid stereospecifically modulates human monocyte IL-1 production and surface HLA-DR antigen expression, T-cell IL-2 production and CD4/CD8 ratio

scientific article published on 01 December 1989

Co-occurrence of allergic sensitization and type 1 diabetes

scientific article published on 01 July 2010

Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity.

scientific article published on October 2010

Comparison of enterovirus-specific cellular immunity in two populations of young children vaccinated with inactivated or live poliovirus vaccines

scientific article published on 01 July 1999

Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes

scientific article

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes

scientific article published on 5 February 2018

Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity

scientific article published on 20 February 2014

Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.

scientific article published on 28 January 2014

Cross-reactions between microbes and tissue as an inducer of autoimmune responses

scientific article published in January 1991

Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase

scientific article published on 01 March 1991

Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase

scientific article published on 01 January 1993

DETECTION OF LACTOBACILLI IN MONTHLY MAIL-IN STOOL SAMPLES FROM 3-18 MONTHS OLD INFANTS AT GENETIC RISK FOR TYPE 1 DIABETES.

scientific article

Decline of mumps antibodies in type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland. Childhood Diabetes in Finland Study Group

scientific article published on 01 December 1993

Decreased antibody reactivity to Epstein-Barr virus capsid antigen in type 1 (insulin-dependent) diabetes mellitus ⬇️

scientific article published on April 1, 1991

Defective HLA class II expression in monocytes of type 1 diabetic patients. The Childhood Diabetes in Finland Study Group

scientific article published on 01 May 1993

Defective autologous mixed leukocyte reaction in newly diagnosed type 1 diabetes mellitus

scientific article published on 01 March 1988

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

scientific article published on 16 January 2014

Detection of enterovirus in the thyroid tissue of patients with graves' disease

scientific article published on 21 December 2012

Detection of enteroviruses in the intestine of type 1 diabetic patients

scientific article published on 07 November 2007

Development and maturation of norovirus antibodies in childhood

scientific article

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

scientific article published on 09 June 2017

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

scientific article published on 23 March 2012

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling

article

Effect of coincident enterovirus infection and cows' milk exposure on immunisation to insulin in early infancy

scientific article published on 01 April 2002

Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study.

scientific article published on 23 July 2014

Enterovirus antibodies in relation to islet cell antibodies in two populations with high and low incidence of type 1 diabetes

scientific article published on 01 December 1999

Enterovirus antibody levels during the first two years of life in prediabetic autoantibody-positive children.

scientific article published in July 2001

Enterovirus infection during pregnancy is not a risk factor for celiac disease in the offspring

scientific article published on 01 November 2002

Enterovirus infections and enterovirus specific T-cell responses in infancy

article

Enterovirus infections and insulin dependent diabetes mellitus--evidence for causality.

scientific article published on April 1998

Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study

scientific article published on 01 January 2003

Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial.

scientific article published in May 2003

Enterovirus infections in young infants: are children still protected by maternal antibodies?

scientific article published in September 2011

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes

scientific article published on 8 November 2017

Enteroviruses and the risk of MS in the Finnish Twin Cohort.

scientific article published in September 2005

Evaluation of infectious etiology in subacute thyroiditis--lack of association with coxsackievirus infection.

scientific article published on April 1998

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

scientific article published on 5 November 2013

Evolution and conservation in human parechovirus genomes.

scientific article

Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes

scientific article published on 12 December 2009

Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study

scientific article published on 15 June 2007

First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age.

scientific article published on 2 March 2018

Food diversity in infancy and the risk of childhood asthma and allergies.

scientific article published on 25 January 2014

Gut virome sequencing in children with early islet autoimmunity.

scientific article published on 12 February 2015

Half-lives of PAHs and temporal microbiota changes in commonly used urban landscaping materials.

scientific article published on 19 March 2018

High-throughput multiplex quantitative polymerase chain reaction method for Giardia lamblia and Cryptosporidium species detection in stool samples

scientific article published on 27 April 2015

Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices.

scientific article published on 17 April 2018

Human enterovirus 71 strains in the background population and in hospital patients in Finland.

scientific article published on 21 December 2012

Human parechovirus 1 infections in young children--no association with type 1 diabetes

scientific article published on 01 April 2007

Human parechovirus and the risk of type 1 diabetes.

scientific article

Human parechovirus as a minor cause of acute otitis media in children.

scientific article published on 8 November 2014

Human parechovirus seroprevalence in Finland and the Netherlands.

scientific article published on 23 July 2013

Human parechoviruses are frequently detected in stool of healthy Finnish children.

scientific article published on 8 March 2012

Human rhinoviruses including group C are common in stool samples of young Finnish children

scientific article published on 27 December 2012

Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome.

scientific article published in September 2003

Humoral immunity against viral antigens in type 1 diabetes: altered IgA-class immune response against Coxsackie B4 virus.

scientific article published in April 1986

Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease.

scientific article published on 15 January 2014

Increased chemiluminescence of whole blood and normal T-lymphocyte subsets in severe nodular acne and acne fulminans

scientific article published on 01 January 1995

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

scientific article published on 19 November 2013

Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis.

scientific article

Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E

scientific article published on 01 December 2008

Interaction of enterovirus infection and cow's milk-based formula nutrition in type 1 diabetes-associated autoimmunity

article

Intrauterine exposure to maternal enterovirus infection as a risk factor for development of autoimmune thyroiditis during childhood and adolescence.

scientific article

Introduction of complementary foods in infancy and atopic sensitization at the age of 5 years: timing and food diversity in a Finnish birth cohort

scientific article published on 15 February 2013

Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran

scientific article published on 5 June 2015

Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. Childhood Diabetes in Finland (DiMe) Study Group

scientific article published on 01 March 1997

Isolation of enterovirus strains from children with preclinical Type 1 diabetes.

scientific article published in February 2004

Low mumps antibody levels induced by mumps-measles-rubella vaccinations in type 1 diabetic children

scientific article published on 01 December 1994

Maternal antibodies in breast milk protect the child from enterovirus infections

scientific article published on 01 May 2007

Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus

scientific article published on 01 August 2002

Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY

scientific article published on October 2013

Mumps infections in the etiology of type 1 (insulin-dependent) diabetes

scientific article published on 01 November 1988

Mumps virus infects beta cells in human fetal islet cell cultures upregulating the expression of HLA class I molecules.

scientific article

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

scientific article published on 22 September 2008

Nature-derived microbiota exposure as a novel immunomodulatory approach.

scientific article

New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms.

scientific article published on 6 February 2018

Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

scientific article

No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children.

scientific article published in December 2001

Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.

scientific article published on June 2017

PCR inhibition in stool samples in relation to age of infants.

scientific article

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

article

Paralytic poliomyelitis in Finland

scientific article published on 01 August 1985

Predominance of serum antibodies to synthetic peptide stemming from HPV 18 open reading frame E2 in cervical adenocarcinoma ⬇️

scientific article published on June 1, 1992

Presence of human enteric viruses in the stools of healthy Malawian 6-month-old infants.

scientific article published on April 2014

Quantitative CrAssphage real-time PCR assay derived from data of multiple geographically distant populations.

scientific article published on 3 January 2018

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

scientific article published on 9 January 2017

Real-time PCR for rapid diagnosis of entero- and rhinovirus infections using LightCycler

scientific article published on 01 February 2004

Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project.

scientific article published in April 2004

Relationship between the incidence of type 1 diabetes and maternal enterovirus antibodies: time trends and geographical variation

scientific article published on 19 May 2005

Responses of coxsackievirus B4-specific T-cell lines to 2C protein-characterization of epitopes with special reference to the GAD65 homology region.

scientific article published on May 2001

Restricted TCR V beta gene expression and enterovirus infection in type I diabetes: a pilot study

scientific article published on 01 December 2000

Role of enterovirus infections in IgE sensitization

scientific article published on 01 February 2012

Seroconversion to islet autoantibodies after enterovirus infection in early pregnancy

scientific article published on 02 July 2012

Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: a prospective study. The Childhood Diabetes in Finland Study Group

scientific article published on 01 June 1995

Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments

scientific article published on 11 December 2007

Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate.

scientific article published in January 2007

Soluble adhesion molecules in young children with signs of beta-cell autoimmunity--prospective follow-up from birth

scientific article published on 01 May 2006

Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group

scientific article published on 01 January 1997

Suppression of autologous mixed leukocyte reaction in type 1 diabetes mellitus by in vivo-activated T lymphocytes

Synthetic peptides as diagnostic tools in virology.

scientific article

T cell responses to enterovirus antigens and to beta-cell autoantigens in unaffected children positive for IDDM-associated autoantibodies

article

T-cell responses to enterovirus antigens in children with type 1 diabetes

scientific article published on 01 August 2000

The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens

scientific article published on 05 July 2003

The diagnosis of insulitis in human type 1 diabetes.

scientific article

The role of viruses in human diabetes.

scientific article

Time trends in allergic sensitisation and Helicobacter pylori prevalence in Finnish pregnant women.

scientific article published on 2 April 2009

Time-resolved fluorescence imaging of islet cell autoantibodies

scientific article published on 01 October 2006

Urbanization Reduces Transfer of Diverse Environmental Microbiota Indoors.

scientific article

Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue

scientific article published on 21 August 2010

Vipie: web pipeline for parallel characterization of viral populations from multiple NGS samples.

scientific article

Viral infections and atopy in Brazil

scientific article published on 08 March 2012

Virus infections as potential targets of preventive treatments for type 1 diabetes

scientific article published on 28 December 2012

Why is juvenile-onset diabetes common in Finland?

scientific article published on January 1, 1990

[Delayed effects of viral infections]

scientific article published on 01 January 2000

[The role of enterovirus in the pathogenesis of Insulin-dependent diabetes mellitus]

scientific article published on 01 January 1996

[Why has the occurence of diabetes mellitus type I increased in Finland after the second World War?]

scientific article published on 01 January 2004

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