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List of works by José Neptuno Rodríguez-López

A continuous spectrophotometric method for the determination of monophenolase activity of tyrosinase using 3-methyl-2-benzothiazolinone hydrazone

scientific article published on 01 January 1994

A review on spectrophotometric methods for measuring the monophenolase and diphenolase activities of tyrosinase.

scientific article published on 25 October 2007

Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols

scientific article published on 01 April 2000

Analysis and interpretation of the action mechanism of mushroom tyrosinase on monophenols and diphenols generating highly unstable o-quinones.

scientific article published in July 2001

Analysis of cholinesterases in human prostate and sperm: implications in cancer and fertility.

scientific article published on 29 March 2010

Antifolates as antimycotics? Connection between the folic acid cycle and the ergosterol biosynthesis pathway in Candida albicans

scientific article published on 13 October 2006

Binding of natural and synthetic polyphenols to human dihydrofolate reductase.

scientific article

Calculating molar absorptivities for quinones: application to the measurement of tyrosinase activity.

scientific article published on 26 January 2006

Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer.

scientific article

Catalysis and inactivation of tyrosinase in its action on hydroxyhydroquinone.

scientific article published on 27 February 2014

Catalytic oxidation of o-aminophenols and aromatic amines by mushroom tyrosinase

scientific article published on 22 July 2011

Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.

scientific article published on 7 February 2011

Compound I formation in artichoke (Cynara scolymus L.) peroxidase is modulated by the equilibrium between pentacoordinated and 6-aquo hexacoordinated forms of the heme and by calcium ions.

scientific article published in July 2003

Determination and applications of the molar absorptivity of phenolic adducts with captopril and mesna.

scientific article published in February 2009

Deuterium isotope effect on the oxidation of monophenols and o-diphenols by tyrosinase.

scientific article published on June 2004

Directed phenotype switching as an effective antimelanoma strategy.

scientific article

Effect of distal cavity mutations on the binding and activation of oxygen by ferrous horseradish peroxidase

scientific article published on 01 January 1997

Effect of tetrahydropteridines on the monophenolase and diphenolase activities of tyrosinase

scientific article published in August 2007

Effects of a synthetic antitumoral catechin and its tyrosinase-processed product on the structural properties of phosphatidylcholine membranes

scientific article published on 8 February 2014

Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase.

scientific article published on 7 May 2010

Ellagic acid: characterization as substrate of polyphenol oxidase.

scientific article

Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine.

scientific article published in August 2005

Enzyme inactivation analysis for industrial blanching applications: comparison of microwave, conventional, and combination heat treatments on mushroom polyphenoloxidase activity

scientific article published on 01 November 1999

Factors influencing the antifolate activity of synthetic tea-derived catechins.

scientific article published on 16 July 2013

Generation of hydrogen peroxide in the melanin biosynthesis pathway.

scientific article published on 15 April 2009

Hydrogen peroxide helps in the identification of monophenols as possible substrates of tyrosinase

scientific article published on 07 December 2013

Hydroxylation of p-substituted phenols by tyrosinase: further insight into the mechanism of tyrosinase activity.

scientific article published on 22 June 2012

Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.

scientific article published on 11 April 2013

Inhibition of Stenotrophomonas maltophilia dihydrofolate reductase by methotrexate: a single slow-binding process

scientific article published on 01 August 2007

Kinetic characterisation of o-aminophenols and aromatic o-diamines as suicide substrates of tyrosinase ⬇️

scientific article published on February 10, 2012

Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.

scientific article published in December 2002

Kinetic characterization of the enzymatic and chemical oxidation of the catechins in green tea.

scientific article

Kinetic characterization of the oxidation of carbidopa and benserazide by tyrosinase and peroxidase.

scientific article

Kinetic characterization of the oxidation of chlorogenic acid by polyphenol oxidase and peroxidase. Characteristics of the o-quinone

scientific article published on 01 February 2007

Kinetic characterization of the oxidation of esculetin by polyphenol oxidase and peroxidase

scientific article published on 07 February 2007

Kinetic study of the effects of calcium ions on cationic artichoke (Cynara scolymus L.) peroxidase: calcium binding, steady-state kinetics and reactions with hydrogen peroxide.

scientific article published in September 2004

Kinetic study of the inactivation of ascorbate peroxidase by hydrogen peroxide.

scientific article published on June 2000

Laser Photolysis Behavior of Ferrous Horseradish Peroxidase with Carbon Monoxide and Cyanide: Effects of Mutations in the Distal Heme Pocket ⬇️

scientific article published on November 14, 1995

Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

scientific article published on August 2010

Mechanisms of compound I formation in heme peroxidases.

scientific article

Melanogenesis Inhibition Due to NADH ⬇️

scientific article published on September 7, 2010

Melanogenesis inhibition by tetrahydropterines.

scientific article published on 18 August 2009

Melanoma activation of 3-o-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin to a potent irreversible inhibitor of dihydrofolate reductase.

scientific article

Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.

scientific article published on 29 March 2012

Method for the determination of molar absorptivities of thiol adducts formed from diphenolic substrates of polyphenol oxidase.

scientific article published in October 2002

Michaelis constants of mushroom tyrosinase with respect to oxygen in the presence of monophenols and diphenols

scientific article published on 01 April 2002

Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.).

scientific article published in June 2005

Mutation of Distal Residues of Horseradish Peroxidase: Influence on Substrate Binding and Cavity Properties†

scientific article published on 01 February 1997

Opposite effects of peroxidase in the initial stages of tyrosinase-catalysed melanin biosynthesis.

scientific article

Oxidation by mushroom tyrosinase of monophenols generating slightly unstable o-quinones.

scientific article

Oxymetric and spectrophotometric study of the ascorbate oxidase activity shown by frog epidermis tyrosinase

scientific article published on 01 August 1996

Persister state-directed transitioning and vulnerability in melanoma

scientific article published on 01 June 2022

Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells

scientific article

Purification and Kinetic Characterization of an Anionic Peroxidase from Melon (Cucumis meloL.) Cultivated under Different Salinity Conditions

scientific article published on 01 May 2000

Purification and characterization of a new cationic peroxidase from fresh flowers of Cynara scolymus L

scientific article published on 01 March 2003

Purification and kinetic properties of human recombinant dihydrofolate reductase produced in Bombyx mori chrysalides.

scientific article published on November 2010

Quantification of the antioxidant capacity of different molecules and their kinetic antioxidant efficiencies

scientific article published on 01 February 2010

Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

scientific article

Reactivity of horseradish peroxidase compound II toward substrates: kinetic evidence for a two-step mechanism

scientific article published on 01 October 2000

Stereospecific inactivation of tyrosinase by L- and D-ascorbic acid.

scientific article

Stopped-flow and steady-state study of the diphenolase activity of mushroom tyrosinase

scientific article published on 01 August 2000

Study of umbelliferone hydroxylation to esculetin catalyzed by polyphenol oxidase

scientific article published on 01 January 2013

Suicide inactivation of the diphenolase and monophenolase activities of tyrosinase.

scientific article published on July 2010

Suicide inactivation of tyrosinase in its action on tetrahydropterines

scientific article

Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.

scientific article

Targeting the epigenetic machinery of cancer cells

scientific article published on 27 January 2014

Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.

scientific article

Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans

scientific article published on 03 April 2006

Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase

scientific article

The Distal Cavity Structure of Carbonyl Horseradish Peroxidase As Probed by the Resonance Raman Spectra of His 42 Leu and Arg 38 Leu Mutants†

scientific article published on 01 September 1998

The Relationship between the IC<sub>50</sub> Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition

scientific article published on 13 May 2022

The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.

scientific article published on October 2008

The antifolate activity of tea catechins.

scientific article published in March 2005

The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate.

scientific article

The inactivation and catalytic pathways of horseradish peroxidase with m-chloroperoxybenzoic acid. A spectrophotometric and transient kinetic study

scientific article published on 01 February 1997

The inactivation of horseradish peroxidase isoenzyme A2 by hydrogen peroxide: an example of partial resistance due to the formation of a stable enzyme intermediate.

scientific article published in June 2001

Thermal inactivation of mushroom polyphenoloxidase employing 2450 MHz microwave radiation

scientific article published on 01 August 1999

Tyrosinase-catalyzed hydroxylation of hydroquinone, a depigmenting agent, to hydroxyhydroquinone: A kinetic study

scientific article published on 04 May 2014

Unification for the expression of the monophenolase and diphenolase activities of tyrosinase

scientific article published on 01 September 2002

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