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List of works by Irina Pikuleva

,-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

scientific article published on 25 July 2018

2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production

scientific article published on 22 July 2020

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier.

scientific article published on 08 December 2013

A simple and rapid method to measure cholesterol binding to P450s and other proteins

scientific article published on 16 April 2005

Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis

scientific article

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

scientific journal article

An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1)

scientific article

Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1

scientific article

Assessment of cholesterol homeostasis in the living human brain

scientific article published in 2022

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1: UNUSUAL FEATURES AND SPECTRAL RESPONSE

scientific article

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

scientific article (publication date: 9 December 2003)

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

scientific article published on 01 July 2019

CYP46A1-dependent and independent effects of efavirenz treatment

scientific article published on 29 October 2020

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

scientific article published in October 2003

Chemical modification of adrenocortical cytochrome P-450scc with tetranitromethane

scientific article published on 01 November 1984

Chemical modification of rabbit IgG with N-dansylaziridine. Investigation of the properties of dansylated antibodies

scientific article published on 01 April 1991

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. ⬇️

scientific article

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

scientific article published on 01 July 2019

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis

scientific article published in March 2005

Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols

scientific article published on 29 July 2015

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis

scientific article published on 2 December 2015

Cholesterol in the retina: the best is yet to come.

scientific article

Cholesterol-metabolizing cytochromes P450

scientific article

Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering

scientific article published on 01 November 2008

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.

scientific article published on 24 June 2017

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

scientific article published on 10 January 2009

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

scientific article

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

scientific article

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

scientific article published on 11 February 2017

Cytochromes p450: roles in diseases

scientific article published on 30 April 2013

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies

scientific article published on 01 April 2006

Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo

scientific article published on 30 November 2017

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

scientific article

Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction

scientific article published in November 1997

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications

scientific article

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

scientific article published in July 1997

Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.

scientific article published on 29 December 2011

Genetically engineered bacterial cells and applications.

scientific article published on December 1995

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice.

scientific article published on 25 June 2015

In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine

scientific article

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

scientific article published on 03 November 2019

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

scientific article published on 22 June 2017

Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents

scientific article published on 23 October 2012

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

scientific article

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

scientific article published on 04 March 2020

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

scientific article published on 07 April 2016

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

scientific article

Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters

scientific article

Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy

scientific article

Mass spectrometry detection of isolevuglandin adduction to specific protein residues

scientific article

Mass spectrometry quantification of PICALM and AP180 in human frontal cortex and neural retina

scientific article published on 13 August 2013

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)

scientific article (publication date: July 2002)

Mechanisms that minimize retinal impact of apolipoprotein E absence

scientific article published on 17 October 2018

Membrane binding and substrate access merge in cytochrome P450 7A1, a key enzyme in degradation of cholesterol

scientific article

Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1.

scientific article

Metabolism of 4 beta -hydroxycholesterol in humans.

scientific article published on 20 June 2002

Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.

scientific article

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.

scientific article

Novel sterols synthesized via the CYP27A1 metabolic pathway.

scientific article published in December 2003

On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain

scientific article published on 12 December 2016

Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina

scientific article

Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments

scientific article

Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice

scientific article published on 18 December 2013

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

scientific article published in September 2004

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

scientific article published on 11 March 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

scientific article published on 22 August 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

scientific article

Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1

scientific article (publication date: 26 June 2001)

Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain

scientific article

Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain

scientific article published on 11 May 2015

Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol

scientific article published on 16 August 2018

Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells

scientific article published on 11 August 2016

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal

scientific article published on 16 November 2018

Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

scientific article

Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins

scientific article

Selective chemical modification of cytochrome P-450SCC lysine residues. Identification of lysines involved in the interaction with adrenodoxin

scientific article

Spatial distribution of the pathways of cholesterol homeostasis in human retina

scientific article

Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry

scientific article published on May 2009

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

scientific article

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

scientific article

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain

scientific article

Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels

scientific article published on 21 May 2020

Studies of distant members of the P450 superfamily (P450scc and P450c27) by random chimeragenesis.

scientific article

Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1

scientific article

The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina

scientific article published on 12 December 2019

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection

scientific article

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

scientific article

The tertiary structure of full-length bovine adrenodoxin suggests functional dimers

scientific article

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

scientific article published on 26 October 2017

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

scientific article published on 19 April 2008

[Chemical modification of cholesterol-hydroxylating cytochrome P450 from bovine adrenal cortex mitochondria by acetylimidazole]

scientific article published on 01 October 1987

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