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List of works by Darragh G. McArt

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

scientific article published on 27 June 2019

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

scientific article published on 13 February 2019

ACE: A Workbench using Evolutionary Genetic Algorithms for analysing association in TCGA Data

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

scientific article published on 29 October 2013

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.

scientific article published on 26 September 2014

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

scientific article published on 17 December 2018

Automated tumor analysis for molecular profiling in lung cancer

scientific article

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

scientific article published on 13 February 2018

Building a 'Repository of Science': The importance of integrating biobanks within molecular pathology programmes.

scientific article published on 23 September 2016

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

scientific article published on 31 May 2017

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

scientific article published on 5 May 2016

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches

scientific article published on 31 December 2019

Comet sensitivity in assessing DNA damage and repair in different cell cycle stages.

scientific article published on 16 February 2010

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.

scientific article

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

scientific article (publication date: 2013)

Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

scientific article published on 22 December 2015

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.

scientific article published on 29 March 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

scientific article

Digital pathology and image analysis in tissue biomarker research

scientific article published on 15 July 2014

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.

scientific article published on 02 June 2016

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

scientific article

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

scientific article

Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma.

scientific article

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

scientific article

Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping

scientific article

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

scientific article published on 13 May 2016

Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

article

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

scientific article

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

scientific article published on 10 December 2016

Modelling the comet assay.

scientific article published on August 2009

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

scientific article published on 9 December 2015

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

scientific article published on 16 June 2017

PICan: An integromics framework for dynamic cancer biomarker discovery

scientific article published on 4 March 2015

PP28. THERAPEUTIC COMPOUND DISCOVERY AND VALIDATION OF DRUGS TARGETING A RECURRENT GLIOBLASTOMA (GBM) PHENOTYPE USING LINCS COMPOUNDS VIA QUADRATIC ANALYSES.

scientific article published in January 2017

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer.

scientific article published on 5 December 2013

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

scientific article published on 7 February 2018

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

scientific article

QuPath: Open source software for digital pathology image analysis

scientific article published on 4 December 2017

QuPath: Open source software for digital pathology image analysis

Quantification of HER2 heterogeneity in breast cancer-implications for identification of sub-dominant clones for personalised treatment

scientific article published on 21 March 2016

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.

scientific article published on 2 May 2016

Systematic random sampling of the comet assay.

scientific article

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities

scientific article

The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

scientific article published on 16 April 2014

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

scientific article published in May 2015

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

scientific article published on 01 June 2018

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

scientific article published on 26 October 2016

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

scientific article

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis

scientific article

cudaMap: a GPU accelerated program for gene expression connectivity mapping

scientific article

p16 as a prognostic indicator in ovarian/tubal high-grade serous carcinoma

scientific article published on 14 July 2015

samExploreR: exploring reproducibility and robustness of RNA-seq results based on SAM files.

scientific article published on 10 July 2016

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