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List of works by Tsuyoshi Goto

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.

scientific article published on 28 July 2017

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.

scientific article published on 5 March 2015

13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor γ in adipocytes

scientific article published on 27 November 2014

4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages.

scientific article published on 17 December 2012

4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages.

scientific article published on 13 March 2015

4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells.

scientific article

6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

scientific article

9-Oxo-10(E),12(Z),15(Z)-Octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor α in Hepatocytes.

scientific article published on 19 September 2015

9-oxo-10(E),12(E)-Octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

scientific article published on 18 November 2010

A Phytol-Enriched Diet Activates PPARα in the Liver and Brown Adipose Tissue to Ameliorate Obesity-Induced Metabolic Abnormalities.

scientific article published on 27 January 2018

A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression

scientific article published on 20 May 2019

A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors

scientific article published on 20 December 2018

Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism.

scientific article published on August 2003

Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle.

scientific article

Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes.

scientific article published on 18 June 2016

Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice

scientific article published on 01 September 2013

Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

scientific article published on 2 April 2011

Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity

scientific article published on 01 July 2011

An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice

scientific article published on 01 January 2015

Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor.

scientific article

Apo-12'-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-Activated Receptor γ Activation

scientific article published on 04 December 2018

Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice.

scientific article published on 28 October 2011

Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation.

scientific article published on 14 March 2013

Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes.

scientific article published on January 2008

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

scientific article published on 21 August 2019

Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice

scientific article published on 21 November 2012

Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.

scientific article published on 3 November 2009

Blockade of 4-1BB and 4-1BBL interaction reduces obesity-induced skeletal muscle inflammation.

scientific article published on 18 December 2013

Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.

scientific article published on August 2004

Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism

scientific article published on 16 November 2020

Comparative and stability analyses of 9- and 13-Oxo-octadecadienoic acids in various species of tomato

scientific article published on 07 August 2011

Correction to Rice Koji Extract Enhances Lipid Metabolism through Peroxisome Proliferator-Activated Receptor Alpha (PPARα) Activation in Mouse Liver.

scientific article published on 28 December 2016

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells.

scientific article published on 16 October 2013

Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes.

scientific article published on July 2011

Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.

scientific article published in September 2009

Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein

scientific article published on 07 February 2011

Development of a novel transgenic rice with hypocholesterolemic activity via high-level accumulation of the α' subunit of soybean β-conglycinin

article

Dietary factors evoke thermogenesis in adipose tissues

scientific article published on 18 January 2014

Dietary low-fat soy milk powder retards diabetic nephropathy progression via inhibition of renal fibrosis and renal inflammation.

scientific article published on 17 October 2016

Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.

scientific article

Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice.

scientific article published on 24 November 2010

Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes ⬇️

scientific article published on 11 January 2019

Epigallocatechin gallate changes mRNA expression level of genes involved in cholesterol metabolism in hepatocytes.

scientific article published on 19 August 2011

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

scientific article published on 23 August 2011

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

scientific article published on August 2011

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.

scientific article

Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.

scientific article

Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice.

scientific article published on 29 February 2016

Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

scientific article published on 25 May 2010

Genome science of lipid metabolism and obesity.

scientific article published on 07 April 2009

Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes

scientific article published on 09 April 2020

Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes.

scientific article published on 23 September 2015

Hypothalamic lipid-laden astrocytes induce microglia migration and activation.

scientific article published on 21 May 2017

Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly

scientific article published on 21 August 2014

Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.

scientific article published on 9 January 2013

Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.

scientific article published on 12 September 2007

Involvement of mast cells in adipose tissue fibrosis

scientific article published on 10 December 2013

Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

scientific article published on 11 February 2016

Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.

scientific article published on 27 November 2013

Localization of 9- and 13-oxo-octadecadienoic acids in tomato fruit

scientific article published on 25 July 2014

Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes

scientific article published on 10 October 2019

Long-chain free fatty acid profiling analysis by liquid chromatography-mass spectrometry in mouse treated with peroxisome proliferator-activated receptor α agonist.

scientific article published on 7 November 2013

Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation.

scientific article published on 23 October 2009

Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice.

scientific article

Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α.

scientific article published on 15 December 2014

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

scientific article

Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling.

scientific article published on 23 November 2016

Over-expression of PPARα in obese mice adipose tissue improves insulin sensitivity.

scientific article published on 15 September 2017

Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.

scientific article published on 23 April 2014

Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

scientific article

Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes

scientific article

Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice

scientific article (publication date: 2012)

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes.

scientific article published on 7 November 2015

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

scientific article published on 3 February 2010

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction

scientific article published on 23 June 2017

Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy

scientific article

Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1.

scientific article

Rice Koji Extract Enhances Lipid Metabolism through Proliferator-Activated Receptor Alpha (PPARα) Activation in Mouse Liver.

scientific article published on 10 November 2016

Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

scientific article published in 2021

Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity

scientific article published on 15 February 2018

Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes

scientific article published on 02 May 2019

Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.

scientific article

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation.

scientific article published on 10 June 2017

Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes.

scientific article published on 19 May 2017

Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.

scientific article published on 12 August 2013

Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism.

scientific article

The Mevalonate Pathway Is Indispensable for Adipocyte Survival

scientific article published on 21 October 2018

The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice

scientific article published on 19 September 2018

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

scientific article published on 12 April 2017

The hypocholesterolemic activity of transgenic rice seed accumulating lactostatin, a bioactive peptide derived from bovine milk β-lactoglobulin

scientific article published on 28 March 2011

The involvement of 4-1BB/4-1BBL signaling in glial cell-mediated hypothalamic inflammation in obesity.

scientific article

Theobromine enhances absorption of cacao polyphenol in rats

scientific article published on 31 July 2014

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

scientific article published in September 2011

Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract

scientific article published on 16 December 2011

Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages.

scientific article

Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

scientific article published on 09 November 2011

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.

scientific article published on 3 June 2010

Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions.

scientific article published on 12 January 2018

Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses.

scientific article published on 13 September 2016

Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes

l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.

scientific article published on 18 July 2017

α-Linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40.

scientific article

β-Cryptoxanthin Induces UCP-1 Expression via a RAR Pathway in Adipose Tissue

scientific article published on 11 September 2019

β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte

scientific article published on 17 August 2018

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