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List of works by Zhiwei Chen

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

scientific article published on 01 December 2022

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

scientific article published on 29 January 2015

A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination.

scientific article

A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice

scientific article

AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34 Progenitor Cell Engraftment in Humanized Mice

scientific article published on 30 October 2018

Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope.

scientific article published on March 2010

Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1.

scientific article published on October 2002

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

scientific article published on 25 May 2022

Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.

scientific article

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

article

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

scientific article

Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells.

scientific article published on 28 September 2015

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

scientific article published on 17 April 2020

Brain Invasion by CD4(+) T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice

scientific article

Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents.

scientific article

Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues

scientific article published on 10 December 2007

Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1

scientific article

Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

scientific article published on 25 April 2016

Closing the door to human immunodeficiency virus ⬇️

scientific article published on March 12, 2013

Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

scientific article published on 27 April 2015

Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

scientific article published on 09 March 2021

Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody

scientific article published on 04 November 2008

Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'.

scientific article published on April 2008

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

scientific article published on 19 April 2022

Enhanced infectivity of an R5-tropic simian/human immunodeficiency virus carrying human immunodeficiency virus type 1 subtype C envelope after serial passages in pig-tailed macaques (Macaca nemestrina).

scientific article

Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques ⬇️

scientific article published on February 2, 2011

F18, a novel small-molecule nonnucleoside reverse transcriptase inhibitor, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis.

scientific article published on 28 October 2011

Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City.

scientific article

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mang

scientific article published in June 1996

Gut-homing Δ42PD1(+)Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

scientific article published on 14 August 2017

HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China ⬇️

scientific article published on November 21, 2003

HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling.

scientific article published on 11 March 2009

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

scientific article

Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus.

scientific article

High Prevalence of HIV Infection Among Women and Their Children in Henan Province, China

article

High neutralizing antibody titer in intensive care unit patients with COVID-19

scientific article published on 03 July 2020

High prevalence of four novel astrovirus genotype species identified from rodents in China

scientific article published on 25 May 2017

Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain.

scientific article

Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission.

scientific article published on 31 October 2003

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.

scientific article published in May 1997

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model

scientific article

Imbalances of gut-homing CD4+ T-cell subsets in HIV-1-infected Chinese patients.

scientific article published on September 2013

In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors.

scientific article published on 8 January 2015

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

scientific article published on 29 March 2022

Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.

scientific article published in May 1995

Lignosulfonic acid exhibits broadly anti-HIV-1 activity--potential as a microbicide candidate for the prevention of HIV-1 sexual transmission

scientific article

Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus.

scientific article published on 20 December 2006

Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china

scientific article published on December 2004

Monkey Models and HIV Vaccine Research

article

Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.

scientific article

Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine: vaccinia Tiantan strain

scientific article

Multiple-site DNA vaccination enhances immune responses in mice

scientific article published on 08 August 2005

Mycobacterium tuberculosis infection and vaccine development.

scientific article published on 27 February 2016

Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.

scientific article

Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus

scientific article published in January 1998

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.

scientific article published in July 1998

Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC ⬇️

scientific article published on February 17, 2012

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

scientific article published on 22 July 2020

Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine.

scientific article published on 16 April 2013

Primary SIVsm Isolates Use the CCR5 Coreceptor from Sooty Mangabeys Naturally Infected in West Africa: A Comparison of Coreceptor Usage of Primary SIVsm, HIV-2, and SIVmac ⬇️

scientific article published on June 20, 1998

Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

scientific article

Reactivity of a new Pan-B monoclonal antibody (MA6) against human leukaemias

scientific article published on 01 January 1989

Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.

scientific article

Repressive effect of primary virus replication on superinfection correlated with gut-derived central memory CD4(+) T cells in SHIV-infected Chinese rhesus macaques

scientific article

SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus.

scientific article

Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain.

scientific article

Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques.

scientific article published on 09 December 2015

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.

scientific article published on 20 February 2018

The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1.

scientific article published on 21 September 2016

The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes.

scientific article

The development of an AIDS mucosal vaccine.

scientific article

The development of anti-HIV-1 drugs.

scientific article published on February 2010

The function of simian chemokine receptors in the replication of SIV ⬇️

scientific article published on June 1, 1998

The route of inoculation determines the tissue tropism of modified vaccinia Tiantan expressing the spike glycoprotein of SARS-CoV in mice.

scientific article published in May 2010

Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.

scientific article

Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment.

scientific article published on 14 August 2014

Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice

scientific article published on 01 March 2019

Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

scientific article published on 16 October 2018

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

scientific article published on 28 August 2020

α4β7+ CD4+ effector/effector memory T cells differentiate into productively and latently infected central memory T cells by TGFβ1 during HIV-1 infection.

scientific article published on 31 January 2018

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