List of works - Conor McClenaghan

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

scientific article published on 01 October 2019

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

scientific article published on 01 June 2019

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

scientific article published on 24 March 2017

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms.

scientific article

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry

scientific article published on 01 December 2019

Cardiovascular consequences of KATP overactivity in Cantu syndrome

article

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel

scientific article published on 23 August 2017

GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells

scientific journal article

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity

scientific article published on 01 March 2020

Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience

scientific article published on 07 June 2019

Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport

scientific article published on 03 November 2011

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

scientific article published in March 2015

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

scientific article published on 01 October 2018

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states