List of works - Michela De Bellis

A long-term treatment with taurine prevents cardiac dysfunction in mdx mice

scientific article published on 28 September 2018

Calcium Homeostasis Is Altered in Skeletal Muscle of Spontaneously Hypertensive Rats

scientific article published on 30 July 2014

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

scientific article

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

scientific article published on January 2013

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

scientific article

Corrigendum to A long-term treatment with taurine prevents cardiac dysfunction in mdx mice [Translational Research Volume 204 (February 2019) Pages 82-99]

scientific article published on 01 September 2020

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

scientific article published in January 2017

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

scientific article published on 23 July 2008

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

scientific article published on 10 March 2017

Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.

scientific article published on August 2010

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

scientific article published on 12 October 2016

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine.

scientific article

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

scientific article

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

scientific article

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

scientific article published in October 2003

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

scientific article

Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

scientific article published on 11 October 2011

Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ.

scientific article published on 20 March 2014

Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy

scientific article

Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo

scientific article published on 20 March 2020

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

scientific article

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

scientific article published in July 2016

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

scientific article

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

scientific article published in March 2010

Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery

scientific article

List of works by Michela De Bellis

A long-term treatment with taurine prevents cardiac dysfunction in mdx mice

Calcium Homeostasis Is Altered in Skeletal Muscle of Spontaneously Hypertensive Rats

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

Corrigendum to A long-term treatment with taurine prevents cardiac dysfunction in mdx mice [Translational Research Volume 204 (February 2019) Pages 82-99]

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine.

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ.

Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy

Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery