List of works - Alan J Russell

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

scientific article

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

scientific article

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

scientific article published on 13 February 2018

Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

scientific article published in July 2001

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model ⬇️

scientific article

GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women

scientific article published on 01 September 2018

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

scientific article published on 13 November 2018

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear

scientific article published on January 2017

Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organization

scientific article

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.

scientific article published on 28 March 2016

Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.

scientific article

Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear.

scientific article published on 8 February 2017

Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.

scientific article

Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis

article

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

scientific article published on 19 July 2018

The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.

scientific article

The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.

scientific article published on 2 April 2004

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans

scientific article published on December 2014

beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.

scientific article

List of works by Alan J Russell

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model ⬇️

GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear

Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organization

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.

Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.

Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear.

Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.

Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.

The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans

beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.