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List of works by Satoshi Obika

1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three AgI Ions in a Duplex

scientific article published on 10 April 2019

2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex

scientific article published on 18 October 2018

2′‐O,4′‐C‐Aminomethylene‐Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH

scientific article published on January 24, 2011

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 04 July 2019

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

scientific article published on 20 May 2019

A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes

scientific article published on September 27, 2010

Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication

scientific article published on 10 December 2020

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease

scientific article published on 21 May 2019

Amido‐Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency

scientific article published on October 18, 2012

Antisense Drug Discovery and Development

scientific article published on March 1, 2011

Bridged nucleic acid conjugates at 6′-thiol: synthesis, hybridization properties and nuclease resistances

scientific article published on 03 June 2011

Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH

scientific article published on January 9, 2012

Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth

scientific article published on 15 January 2019

Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates

scientific article published on December 20, 2011

Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening.

scientific article

Correction: Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

article

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

scientific article published on 11 December 2020

Design and Concise Synthesis of a Novel Type of Green Fluorescent Protein Chromophore Analogue

scientific article published on August 16, 2012

Design, Synthesis, and Properties of Boat-Shaped Glucopyranosyl Nucleic Acid

scientific article published on October 17, 2011

Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

article

Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides.

scientific article

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])

scientific article published on 01 September 2018

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

scientific article published on 28 August 2019

High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives

scientific article published on 07 January 2019

Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase

scientific article published on 24 January 2019

Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides

scientific article published on 6 December 2017

Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy

scientific article published on July 29, 2011

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

scientific article published on 01 November 2019

Interrupted 2′-O,4′-C-Aminomethylene Bridged Nucleic Acid Modification Enhances Pyrimidine Motif Triplex-Forming Ability and Nuclease Resistance Under Physiological Condition

scientific article published on January 1, 2011

Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties

scientific article published on 29 November 2019

Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction

scientific article published on November 19, 2010

Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates

scientific article published on November 12, 2010

Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

scientific article published on September 26, 2012

Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

scientific article published on 09 April 2020

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.

scientific article

Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages

scientific article published on 07 January 2020

Synthesis and Properties of a Bridged Nucleic Acid with a Perhydro-1,2-oxazin-3-one Ring

scientific article published on November 15, 2011

Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure

scientific article published on May 22, 2012

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides

scientific article published on 12 November 2020

Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base.

scientific article published on 18 September 2017

Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides

scientific article published on 10 October 2019

Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

scientific article published on 12 October 2019

Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction.

scientific article published on 12 March 2018

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA

scientific article published on 24 January 2020

Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability

scientific article published on 04 March 2019

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.

scientific article