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List of works by Don A McClain

A genetic mechanism for Tibetan high-altitude adaptation

scientific article

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues

scientific article published on 01 June 1997

Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

scientific article published on 18 December 2003

Adipocyte iron regulates adiponectin and insulin sensitivity

scientific article

Adipocyte iron regulates leptin and food intake

scientific article

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

scientific article

Analysis of hepatic glycogen-associated proteins.

scientific article

Analysis of the stimulation-inhibition paradox exhibited by lymphocytes exposed to concanavalin A ⬇️

scientific article published on December 1, 1976

Anti-obesity and pro-diabetic effects of hemochromatosis

scientific article

Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.

scientific article published on 25 August 2004

Chimeric receptors expressing juxtamembrane sequences of the insulin receptor undergo rapid endocytosis in the absence of receptor tyrosine kinase activity.

scientific article published in June 1995

Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.

scientific article published on 16 January 2007

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

scientific article published on 2 April 2009

Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

scientific article published on 27 September 2012

Diabetes and hemochromatosis

scientific article published on January 2014

Dietary iron controls circadian hepatic glucose metabolism through heme synthesis

scientific article

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

scientific article published on 01 May 1991

Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison.

scientific article

Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia

scientific article published on 01 April 2000

Further insights into leptin action

scientific article published on 01 September 1998

Genetic determinants of Tibetan high-altitude adaptation.

scientific article

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease

scientific article

Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway

scientific article published on 01 August 1993

Hexosamines as mediators of nutrient sensing and regulation in diabetes.

scientific article

Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.

scientific article published on 27 September 2005

Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13

scientific article

Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.

scientific article

Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway

scientific article

Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study.

scientific article

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

scientific article published on 01 April 1998

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

scientific article published on January 2003

Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae)

scientific article published on 07 February 2015

Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

scientific article published in May 2014

Introduction to a mini-forum on "glyconutrients"

scientific article published on 01 September 2008

Iron and diabetes risk

scientific article published on March 2013

Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB

scientific article published on 01 February 2019

Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. ⬇️

scientific article

Iron regulates glucose homeostasis in liver and muscleviaAMP‐activated protein kinase in mice ⬇️

scientific article published on March 20, 2013

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

scientific article

Local release of masitinib alters in vivo implantable continuous glucose sensor performance.

scientific article published on 14 September 2015

Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion

scientific article published on 31 January 2013

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.

scientific article

Metabolic aspects of high-altitude adaptation in Tibetans.

scientific article published on 06 June 2015

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

scientific article

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

scientific article published on 09 September 2012

Muscle damage and muscle remodeling: no pain, no gain?

scientific article

MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.

scientific article published on 12 May 2015

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

scientific article published on 15 February 2009

Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis

scientific article

Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.

scientific article

PAS kinase is required for normal cellular energy balance

scientific journal article

Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic β-cell function and vascularization.

scientific article

Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells

scientific article published on 03 January 2008

Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes

scientific article published on 5 April 2012

Regulation of Akt signaling by O-GlcNAc in euglycemia.

scientific article published on 26 August 2008

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

scientific article published on 26 April 2013

Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans

scientific article

Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

scientific article published on 18 March 2016

Systemic PPARγ Deletion Impairs Circadian Rhythms of Behavior and Metabolism ⬇️

scientific article published on August 10, 2012

The 3T3-L1 adipocyte glycogen proteome.

scientific article

The Utah Center for Clinical and Translational Science: transformation through collaboration

scientific article published on October 2012

The effects of sodium metaperiodate on T and B lymphocytes

scientific article

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts

scientific article published on July 1990

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

scientific article published on 29 January 2009

Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors ⬇️

scientific article published on June 1, 1992

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

scientific article published on 01 January 1997

Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.

scientific article published on 10 December 2008

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