List of works - Alexandra M Antunes

2'-Deoxythymidine adducts from the anti-HIV drug nevirapine.

scientific article

A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications

scientific article published on 31 July 2019

Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.

scientific article published in May 2010

Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir

scientific article

Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes

scientific article published on 20 May 2020

Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz

scientific article published on 08 May 2012

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.

scientific article published on 19 September 2013

Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry.

scientific article

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.

scientific article published on 16 August 2016

Electronic communication in linear oligo(azobenzene) radical anions

scientific article published on 5 December 2013

Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity ⬇️

scientific article published on June 28, 2012

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study

scientific article published on 12 March 2019

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study.

scientific article published on 14 July 2016

High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches

scientific article published on 25 March 2018

Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges

scientific article published on 23 April 2019

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease

scientific article published on 09 January 2019

Molecular motions in amorphous ibuprofen as studied by broadband dielectric spectroscopy.

scientific article published on 8 August 2008

Monitoring abacavir bioactivation in humans: screening for an aldehyde metabolite

scientific article published on 04 March 2013

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model

scientific article published on 03 June 2020

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach

scientific article published on 24 November 2015

New Syntheses of DNA Adducts from Methylated Anilines Present in Tobacco Smoke

scientific article published on 01 December 1999

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

scientific article published on 4 November 2016

N‐terminal valine adduct from the anti‐HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo ⬇️

scientific article published on November 1, 2012

Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

article

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR

Protein adducts as prospective biomarkers of nevirapine toxicity.

scientific article

Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity

scientific article published on 11 November 2011

Scavenging activity of aminoantipyrines against hydroxyl radical.

scientific article published on 2 February 2010

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.

scientific article published on 7 May 2015

Severe Acute Kidney Injury and Double Tubulopathy Due to Dual Toxicity Caused by Combination Antiretroviral Therapy.

scientific article published on 28 November 2018

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats.

scientific article published on 27 March 2015

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

scientific article published on 01 February 2019

Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells.

scientific article published on 8 May 2013

Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

scientific article published on 3 July 2008

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

scientific article published on 12 June 2013

Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium-Chrysin Polyurea Dendrimer Nanoformulation

scientific article published on 19 October 2019

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals

article

The mercapturomic profile of health and non-communicable diseases

scientific article published on 23 April 2019

The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt

scientific article published on 31 December 2013

The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study.

scientific article published on September 2013

Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms.

scientific article published on 6 May 2017

List of works by Alexandra M Antunes

2'-Deoxythymidine adducts from the anti-HIV drug nevirapine.

A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications

Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.

Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir

Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes

Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.

Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry.

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.

Electronic communication in linear oligo(azobenzene) radical anions

Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity ⬇️

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study.

High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches

Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease

Molecular motions in amorphous ibuprofen as studied by broadband dielectric spectroscopy.

Monitoring abacavir bioactivation in humans: screening for an aldehyde metabolite

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach

New Syntheses of DNA Adducts from Methylated Anilines Present in Tobacco Smoke

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

N‐terminal valine adduct from the anti‐HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo ⬇️

Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR

Protein adducts as prospective biomarkers of nevirapine toxicity.

Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity

Scavenging activity of aminoantipyrines against hydroxyl radical.

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.

Severe Acute Kidney Injury and Double Tubulopathy Due to Dual Toxicity Caused by Combination Antiretroviral Therapy.

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats.

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells.

Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium-Chrysin Polyurea Dendrimer Nanoformulation

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals

The mercapturomic profile of health and non-communicable diseases

The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt

The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study.

Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms.