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List of works by Hui-Chih Hung

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22

scientific article published on 20 October 2016

A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence

scientific article published on 19 May 2015

Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade.

scientific article published in October 2006

Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase

scientific article published on 17 December 2020

Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme

scientific article

Biphasic denaturation of human placental alkaline phosphatase in guanidinium chloride

scientific article published on 01 October 1998

Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme).

scientific article

Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase

scientific article published on 12 December 2019

Critical factors determining dimerization of human antizyme inhibitor.

scientific article published on 27 July 2009

Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor.

scientific article

Determinants of nucleotide-binding selectivity of malic enzyme

scientific article

Determinants of the differential antizyme-binding affinity of ornithine decarboxylase

scientific article

Determinants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of glutamine 362

scientific article (publication date: 11 August 2006)

Differentiation of the slow-binding mechanism for magnesium ion activation and zinc ion inhibition of human placental alkaline phosphatase

scientific article

Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.

scientific article published on 13 May 2009

Effects of C-terminal truncation on autocatalytic processing of Bacillus licheniformis gamma-glutamyl transpeptidase

scientific article published on July 2010

Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme.

scientific article published on 27 June 2009

Engineering of the cofactor specificities and isoform-specific inhibition of malic enzyme.

scientific article

Equilibrium protein folding-unfolding process involving multiple intermediates.

scientific article

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme

scientific article

Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4) ⬇️

scientific article published on June 22, 2011

Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

scientific article published on 24 June 2019

Functional role of fumarate site Glu59 involved in allosteric regulation and subunit-subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme.

scientific article published on 12 January 2009

Functional roles of the dimer-interface residues in human ornithine decarboxylase

scientific article

Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4

scientific article

Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion

scientific article published on 9 September 2014

Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346.

scientific article published in November 2008

Inhibitory effect of magnesium ion on the human placental alkaline phosphatase-catalyzed reaction in a reverse micellar system

scientific article published on 01 February 1998

Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme.

scientific article

Metal-Induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme.

scientific article published in February 2004

Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor.

scientific article

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4.

scientific article published on 17 February 2017

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

scientific article

Multiple unfolding intermediates of human placental alkaline phosphatase in equilibrium urea denaturation

scientific article published in December 2001

Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells.

scientific article

Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.

scientific article published on 04 January 2008

Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.

scientific article published in February 2006

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.

scientific article

Slow Binding of Metal Ions to Pigeon Liver Malic Enzyme: A General Case†

scientific article published on 01 November 2000

Structural basis of antizyme-mediated regulation of polyamine homeostasis

scientific article

Structural characteristics of the nonallosteric human cytosolic malic enzyme

scientific article

Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoforms

scientific article published on 01 July 2007

Structure of Stenotrophomonas maltophilia FeoA complexed with zinc: a unique prokaryotic SH3-domain protein that possibly acts as a bacterial ferrous iron-transport activating factor

scientific article

The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells

scientific article published on 11 January 2007

Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.

scientific article

miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity

scientific article published on 05 August 2021

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