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List of works by Farid J Ghadessy

A generic scaffold for conversion of peptide ligands into homogenous biosensors.

scientific article published on 29 March 2013

Analysis of p53 binding to DNA by fluorescence imaging microscopy

scientific article published on 06 April 2012

Analysis of the transactivation domain of the androgen receptor in patients with male infertilitv ⬇️

scientific article published on September 1, 1998

Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides

scientific article published on 04 April 2016

Compartmentalized linkage of genes encoding interacting protein pairs.

scientific article

Compartmentalized self-replication: a novel method for the directed evolution of polymerases and other enzymes.

scientific article published in January 2007

Conservative site-specific and single-copy transgenesis in human LINE-1 elements.

scientific article published on 15 December 2015

Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli

scientific article published on 19 August 2019

Development and structural characterization of an engineered multi-copper oxidase reporter of protein-protein interactions

scientific article published on 15 February 2019

Development of a novel multiplex in vitro binding assay to profile p53-DNA interactions

scientific article published in August 2010

Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization.

scientific article

Directed evolution of λ integrase activity and specificity by genetic derepression

scientific article

Engineered RebH Halogenase Variants Demonstrating a Specificity Switch from Tryptophan towards Novel Indole Compounds

scientific article published on 29 July 2021

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

scientific article

Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases.

scientific article published on 7 September 2016

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

scientific article

Inhibition of nutlin-resistant HDM2 mutants by stapled peptides

scientific article

Laccase-catalyzed synthesis of low molecular weight lignin-like oligomers and their application as UV blocking materials

scientific article

Long Polyglutamine Tracts in the Androgen Receptor Are Associated with ReducedTrans-Activation, Impaired Sperm Production, and Male Infertility1 ⬇️

scientific article published on November 1, 1997

Mdm2 and p53 are highly conserved from placozoans to man.

scientific article

Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions

scientific article published on 11 February 2014

Protein and Protease Sensing by Allosteric Derepression

scientific article published in January 2017

Rapid colorimetric detection of p53 protein function using DNA-gold nanoconjugates with applications for drug discovery and cancer diagnostics

scientific article published on 05 May 2018

Rapid screening of protein-protein interaction inhibitors using the protease exclusion assay

scientific article

Selection of bacteriophage lambda integrases with altered recombination specificity by in vitro compartmentalization.

scientific article

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

scientific article

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

scientific article published on 11 December 2017

Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion ⬇️

scientific article published on August 1, 1998

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