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List of works by Luis Miguel Ruiz-Pérez

1,2-Diphenoxiethane salts as potent antiplasmodial agents.

scientific article

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

scientific article published on 01 July 1996

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

scientific article published in February 2004

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

scientific article published on 8 September 2011

Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

scientific article published on 3 April 2018

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

scientific article published on February 1999

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

scientific article published in October 2003

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

scientific article

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

scientific article published on October 14, 2013

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

scientific article

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

scientific article published on July 2000

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

scientific article

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

scientific article published on August 11, 1995

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

scientific article

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

scientific article published on 8 April 2008

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

scientific article published on 5 July 2008

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

scientific article published on July 1997

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

scientific article published on 10 July 2008

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

scientific article published on 3 May 2006

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

scientific article

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

scientific article published on 19 March 2007

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

scientific article published on 01 April 1985

Effect of poly-l-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells

scientific article published on 01 January 1985

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

scientific article published on 29 August 2012

Evaluation of azasterols as anti-parasitics.

scientific article published in October 2006

Evidence for a wide occurrence of proton-translocating pyrophosphatase genes in parasitic and free-living protozoa

scientific article published on 01 June 2002

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

scientific article published on 14 August 2010

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

scientific article

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

scientific article published on July 2006

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

scientific article published on 30 January 2009

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

scientific article

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

scientific article

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

scientific article published on 01 December 1986

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

scientific article published on 17 August 2017

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

scientific article

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured Vero cells

scientific article published on 01 January 1985

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

scientific article published on 22 December 2011

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

scientific article published on 9 June 2008

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

scientific article published in January 2002

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

scientific article published on 01 February 2009

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

scientific article

MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353

scientific article published on 20 June 2018

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

scientific article

New Antiparasitic Agents

scientific article published on 01 January 1988

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

scientific article

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

scientific article published on August 2004

Novel inhibitors of Leishmanial dihydrofolate reductase.

scientific article published in April 2001

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

scientific article published on 24 March 2005

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

scientific article published on 05 May 2007

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

scientific article published on 6 August 2010

Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics.

scientific article published in September 2005

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

scientific article published in February 2000

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

scientific article published on 01 January 1990

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation

scientific article published on 01 January 1984

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

scientific article published on 29 November 2012

Resistance to reinfection of HeLa cells parasitized by Trypanosoma cruzi

scientific article published on 01 October 1984

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

scientific article

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

scientific article

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

scientific journal article

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article published on May 1999

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents ⬇️

scientific article published on October 29, 2011

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

scientific article

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

scientific article published in February 2005

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