List of works - Leslie B Poole

A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope

scientific article

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.

scientific article published on 20 March 2012

Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids

scientific article published on 06 May 2020

AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.

scientific article

Amphibacillus xylanus NADH oxidase and Salmonella typhimurium alkyl-hydroperoxide reductase flavoprotein components show extremely high scavenging activity for both alkyl hydroperoxide and hydrogen peroxide in the presence of S. typhimurium alkyl-hy ⬇️

scientific article published on October 27, 1995

An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.

scientific article

An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.

scientific article published in February 2002

An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.

scientific article

An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack.

scientific article published in September 2005

Analysis of the Kinetic Mechanism of Enterococcal NADH Peroxidase Reveals Catalytic Roles for NADH Complexes with both Oxidized and Two-Electron-Reduced Enzyme Forms ⬇️

scientific article published on October 31, 1995

Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin

scientific article

Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis

scientific article

Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.

scientific article

Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function

scientific article

Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.

scientific article published on 15 September 2015

Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases

scientific article

Chemical approaches to detect and analyze protein sulfenic acids

scientific article

Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase

scientific article published on August 2010

Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry ⬇️

scientific article published on April 30, 2011

Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.

scientific article

Cysteine p K a Values for the Bacterial Peroxiredoxin AhpC † ‡

scientific article

Cysteine-Based Redox Switches in Enzymes ⬇️

scientific article published on September 17, 2010

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.

scientific article published on 28 August 2015

D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing

scientific article published on 06 September 2013

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).

scientific article published on 27 July 2008

Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.

scientific article published on 19 March 2018

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes

scientific article published on 09 January 2019

Discovering mechanisms of signaling-mediated cysteine oxidation.

scientific article published on February 2008

Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC

scientific article published on 10 February 2015

Distribution and Features of the Six Classes of Peroxiredoxins

scientific article

Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model.

scientific article

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.

scientific article

Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling

scientific article

Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.

scientific article published on January 2013

Experimentally Dissecting the Origins of Peroxiredoxin Catalysis

scientific article

Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice

scientific article

Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins

scientific article

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.

scientific article

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

scientific article published on 06 September 2018

Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines

scientific article (publication date: April 2003)

Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH

scientific article published on 01 February 2003

Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.

scientific article

Introduction to approaches and tools for the evaluation of protein cysteine oxidation

scientific article published on 01 February 2020

Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

scientific article

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species ⬇️

scientific article published on June 13, 2011

Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.

scientific article

Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis ⬇️

scientific article published on July 25, 2011

Mapping the Active Site Helix-to-Strand Conversion of CxxxxC Peroxiredoxin Q Enzymes ⬇️

scientific article published on September 14, 2012

Measurement of Protein Sulfenic Acid Content ⬇️

scientific article published on November 1, 2008

Mitochondria-targeted Probes for Imaging Protein Sulfenylation.

scientific article

Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity

scientific article

NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion

scientific article published on 01 October 2018

Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.

scientific article

Novel Application of 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole To Identify Cysteine Sulfenic Acid in the AhpC Component of Alkyl Hydroperoxide Reductase ⬇️

scientific article published on December 2, 1997

Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins

scientific article published on 08 June 2018

Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.

scientific article published on February 2006

Overview of peroxiredoxins in oxidant defense and redox regulation.

scientific article

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

scientific article published on 21 January 2016

Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.

scientific article

PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family

scientific article

Peroxiredoxin II Regulates Effector and Secondary Memory CD8+T Cell Responses ⬇️

scientific article published on October 10, 2012

Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.

scientific article published on February 2012

Peroxiredoxins in Cancer and Response to Radiation Therapies

scientific article published on 01 January 2019

Peroxiredoxins in parasites.

scientific article

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

scientific article

Protein sulfenic acids in redox signaling.

scientific article published on January 2004

Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.

scientific article

Redox proteins

scientific article published on 01 January 2019

Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.

scientific article published in January 2008

Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.

scientific article published on June 2009

Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy.

scientific article published on 10 September 2015

Requirement for the Two AhpF Cystine Disulfide Centers in Catalysis of Peroxide Reduction by Alkyl Hydroperoxide Reductase ⬇️

scientific article published on October 28, 1997

Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.

scientific article published in October 1997

SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites

scientific article published on 26 July 2018

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins ⬇️

scientific article published on July 8, 2011

Structural Changes Common to Catalysis in the Tpx Peroxiredoxin Subfamily

scientific article

Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization

scientific article

Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.

scientific article published on 4 April 2012

Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin

scientific article

Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form

scientific article published on 22 November 2015

Structure, mechanism and regulation of peroxiredoxins

scientific article (publication date: 2003)

Structure-based Insights into the Catalytic Power and Conformational Dexterity of Peroxiredoxins ⬇️

scientific article published on April 20, 2011

Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin

scholarly article

Synthesis of chemical probes to map sulfenic acid modifications on proteins.

scientific article

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.

scientific article published on 8 September 2017

The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

scientific article

The Sensitive Balance between the Fully Folded and Locally Unfolded Conformations of a Model Peroxiredoxin

scientific article

The basics of thiols and cysteines in redox biology and chemistry

scientific article

The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.

scientific article

The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.

scientific article published on August 2012

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.

scientific article published on 16 October 2013

Tuning of peroxiredoxin catalysis for various physiological roles

scientific article

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

scientific article published on 24 March 2009

Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY

scientific article

Water-soluble triarylphosphines as biomarkers for protein S-nitrosation

scientific article

List of works by Leslie B Poole

A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.

Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids

AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.

Amphibacillus xylanus NADH oxidase and Salmonella typhimurium alkyl-hydroperoxide reductase flavoprotein components show extremely high scavenging activity for both alkyl hydroperoxide and hydrogen peroxide in the presence of S. typhimurium alkyl-hy ⬇️

An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.

An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.

An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.

An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack.

Analysis of the Kinetic Mechanism of Enterococcal NADH Peroxidase Reveals Catalytic Roles for NADH Complexes with both Oxidized and Two-Electron-Reduced Enzyme Forms ⬇️

Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin

Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis

Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.

Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function

Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.

Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases

Chemical approaches to detect and analyze protein sulfenic acids

Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase

Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry ⬇️

Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.

Cysteine p K a Values for the Bacterial Peroxiredoxin AhpC † ‡

Cysteine-Based Redox Switches in Enzymes ⬇️

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.

D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).

Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes

Discovering mechanisms of signaling-mediated cysteine oxidation.

Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC

Distribution and Features of the Six Classes of Peroxiredoxins

Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model.

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.

Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling

Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.

Experimentally Dissecting the Origins of Peroxiredoxin Catalysis

Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice

Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines

Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH

Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.

Introduction to approaches and tools for the evaluation of protein cysteine oxidation

Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species ⬇️

Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.

Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis ⬇️

Mapping the Active Site Helix-to-Strand Conversion of CxxxxC Peroxiredoxin Q Enzymes ⬇️

Measurement of Protein Sulfenic Acid Content ⬇️

Mitochondria-targeted Probes for Imaging Protein Sulfenylation.

Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity

NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion

Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.

Novel Application of 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole To Identify Cysteine Sulfenic Acid in the AhpC Component of Alkyl Hydroperoxide Reductase ⬇️

Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins

Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.

Overview of peroxiredoxins in oxidant defense and redox regulation.

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.

PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family

Peroxiredoxin II Regulates Effector and Secondary Memory CD8+T Cell Responses ⬇️

Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.

Peroxiredoxins in Cancer and Response to Radiation Therapies

Peroxiredoxins in parasites.

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

Protein sulfenic acids in redox signaling.

Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.

Redox proteins

Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.

Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.

Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy.

Requirement for the Two AhpF Cystine Disulfide Centers in Catalysis of Peroxide Reduction by Alkyl Hydroperoxide Reductase ⬇️

Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.

SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins ⬇️

Structural Changes Common to Catalysis in the Tpx Peroxiredoxin Subfamily

Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization

Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.

Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin