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List of works by Timothy S Pardee

A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies.

scientific article

Animal models of leukemia: any closer to the real thing?

scientific article

Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia.

scientific article published on 06 January 2015

Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML).

scientific article published on 23 October 2013

Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner

scientific article

Improving nucleoside analogs via lipid conjugation: Is fatter any better?

scientific article published on 21 January 2016

Mitochondria in cancer metabolism, an organelle whose time has come?

scientific article published on 26 May 2018

Mouse models of human AML accurately predict chemotherapy response

scientific article published on April 2009

Mutational Analysis of the D1/E1 Core Helices and the Conserved N-Terminal Region of Yeast Transcription Factor IIB (TFIIB): Identification of an N-terminal Mutant That Stabilizes TATA-Binding Protein-TFIIB-DNA Complexes ⬇️

scientific article published on December 1, 1997

Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome.

scientific article published on 4 November 2012

Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction ⬇️

scientific article published on August 14, 2012

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity ⬇️

scientific article published on October 17, 2012

Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results

scientific article published on 30 July 2020

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial

scientific article

The N-terminal Region of Yeast TFIIB Contains Two Adjacent Functional Domains Involved in Stable RNA Polymerase II Binding and Transcription Start Site Selection ⬇️

scientific article published on July 10, 1998

The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.

scientific article

The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae.

scientific article published on February 1995

The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia

scientific article

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

scientific article

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).

scientific article

The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study

scientific article published on 12 February 2020

Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway

scientific article published on 29 November 2014

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

scientific article published on 23 February 2012

Yeast and Human RNA polymerase II elongation complexes: evidence for functional differences and postinitiation recruitment of factors

scientific article

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