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List of works by David H. Sherman

A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ

scientific article published on 21 June 2018

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. ⬇️

scientific article published on 27 April 2017

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

scientific article published on 2 November 2017

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

scientific article published on 24 August 2017

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

scientific article published on 03 February 2020

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster

scientific article published on 18 June 2018

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

scientific article published on 29 August 2016

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module

scientific article published on 08 May 2018

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

scientific article

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways

scientific article (publication date: 2014)

Characterization of the initial enzymatic steps of barbamide biosynthesis

scientific article published on 01 June 2006

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

scientific article published on 19 May 2017

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria ⬇️

scientific article

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics

scientific article published on 08 October 2020

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

scientific article published on 08 September 2020

Conformational switch triggered by  -ketoglutarate in a halogenase of curacin A biosynthesis

scientific article

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases

scientific article published on 13 February 2020

Correction to “Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications” ⬇️

scientific article published on 13 December 2017

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

scientific article

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching

scientific article

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

scientific article

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

scientific article

Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973

scientific article published on 19 July 2019

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units

scientific article published on 24 January 2019

Enzyme evolution in fungal indole alkaloid biosynthesis

scientific article published on 01 April 2020

Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows ⬇️

scientific article

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

scientific article published on 05 September 2019

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

scientific article published on 4 August 2017

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

scientific article published on 23 September 2019

GNAT-like strategy for polyketide chain initiation

scientific article

Heterologous Production of 4-O-Demethylbarbamide, a Marine Cyanobacterial Natural Product ⬇️

scientific article published on November 13, 2012

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

scientific article

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair

scientific article published on 01 July 2006

Metamorphic enzyme assembly in polyketide diversification

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway

scientific article published on 16 January 2020

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway

scientific article published on 04 November 2020

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria

scientific article published on 21 March 2009

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

scientific article published on 23 July 2019

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis

scientific article published on November 2009

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

scientific article published on 19 June 2017

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis

scientific article published on 27 November 2019

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

scientific article

Stereoselective Synthesis of Baulamycin A

scientific article published on 07 February 2020

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase

scientific article

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways ⬇️

scientific article published on September 26, 2012

Structural Basis of Polyketide Synthase O-Methylation

scientific article published on 03 December 2018

Structure and activity of DmmA, a marine haloalkane dehalogenase ⬇️

scientific article published on January 4, 2012

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

scientific article

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

scientific article

The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

scientific article published on 23 December 2015

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

scientific article

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

scientific article published on 04 May 2010

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity

scientific article

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