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List of works by Sarah Lummis

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function

scientific article

5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems

scientific article published on 7 May 2015

A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists ⬇️

scientific article published on January 25, 2011

A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor

scientific article published in September 2005

A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue

scientific article published on October 2008

A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

scientific article published on 22 May 2008

A single amino acid determines the toxicity of Ginkgo biloba extracts ⬇️

scientific article published on January 17, 2012

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors

scientific article

An efficient and information-rich biochemical method design for fragment library screening on ion channels

scientific article published on November 2010

Anaesthetic impairment of immune function is mediated via GABA(A) receptors

scientific article

Aromatic Residues in the Fourth Transmembrane-Spanning Helix M4 Are Important for GABAρ Receptor Function

scientific article published on 9 November 2017

Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.

scientific article

Calcium modulation of 5-HT3 receptor binding and function

scientific article published on 16 July 2008

Characterization of Residues in the 5-HT3 Receptor M4 Region That Contribute to Function

scientific article published on 05 March 2019

Characterization of a 5-HT3-ELIC Chimera Revealing the Sites of Action of Modulators

scientific article published on 06 March 2018

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

scientific article

Crotonic Acid Blocks the Gloeobacter Ligand-Gated Ion Channel (GLIC) via the Extracellular Domain

scientific article published on 14 October 2016

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors

scientific article published in PLoS ONE

Cys-loop receptor channel blockers also block GLIC.

scientific article

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor

scientific article published on September 2006

Design, Synthesis, and Structure–Activity Relationships of Highly Potent 5-HT3 Receptor Ligands ⬇️

scientific article published on October 12, 2012

Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia

scientific article

Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor

scientific article published on 20 September 2013

Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory.

scientific article published on December 2006

FlexStation examination of 5-HT3 receptor function using Ca2+ - and membrane potential-sensitive dyes: advantages and potential problems.

scientific article published on 20 July 2005

GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study ⬇️

scientific article published on November 20, 2012

Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site ⬇️

scientific article published on November 5, 2010

Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.

scientific article published on 08 June 2009

Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor

scientific article published on 27 June 2018

Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors

scientific article

Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models

scientific article published on 18 January 2014

Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.

scientific article

Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket

scientific article published on 5 June 2006

M4, the Outermost Helix, is Extensively Involved in Opening of the α4β2 nACh Receptor

scientific article published on 09 December 2020

Many Proline Residues in the Extracellular Domain Contribute to Glycine Receptor Function

scientific article published on 10 August 2020

Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors

scientific article

Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104.

scientific article published on 18 July 2008

Molecular modeling of the GABA(C) receptor ligand-binding domain

scientific article published on 26 October 2005

Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket

scientific article published on 15 December 2011

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

scientific article published on 22 March 2013

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop

scientific article published on 4 April 2006

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

scientific article

Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function

scientific article

Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

scientific article published on April 2003

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC

scientific article published on 21 June 2018

Proline Residues Contribute to Efficient GABAp Receptor Function

scientific article published on 17 November 2020

Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT3 and nACh Receptors

scientific article published on 05 July 2019

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

scientific article published on 19 June 2021

Structural Principles of Serotonin and Granisetron Recognition in a 5-HT3 / Binding Protein Chimera

scholarly article by Divya Kesters et al published January 2012 in Biophysical Journal

Structural basis of ligand recognition in 5-HT3 receptors

scientific article

Structure–Activity Relationships of Quinoxaline‐Based 5‐HT3A and 5‐HT3AB Receptor‐Selective Ligands ⬇️

scientific article published on May 2, 2013

Subtle Differences among 5-HT3AC, 5-HT3AD, and 5-HT3AE Receptors Are Revealed by Partial Agonists

scientific article

The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation

scientific article published on 31 October 2007

The M4 Helix Is Involved in α7 nACh Receptor Function

scientific article published on 04 May 2020

The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain.

scientific article published on 6 April 2017

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors

scientific article

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

scientific article published on May 2015

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor ⬇️

scientific article published on June 4, 2012

The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine

scientific article

The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.

scientific article published on 3 March 2004

The roles of aromatic residues in the glycine receptor transmembrane domain

scientific article published on 06 September 2018

The structural basis of function in Cys-loop receptors.

scientific article published on 20 September 2010

Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives

scientific article

Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.

scientific article published on September 2009

Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors

scientific article published on 02 July 2007

Two amino acid residues contribute to a cation-π binding interaction in the binding site of an insect GABA receptor ⬇️

scientific article published on August 24, 2011

Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

scientific article published in October 2004

Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97

scientific article published on January 2007

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP

scientific article published on 19 February 2015

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