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List of works by Michael Huang

Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia.

scientific article published on August 2013

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

scientific article

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

scientific article published on 23 June 2016

Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxia

scientific article published on April 2014

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

scientific article published on June 2016

Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression.

scientific article published in June 2013

Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.

scientific article

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

scientific article

Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

scientific article published on 16 November 2016

Making a case for albumin – a highly promising drug-delivery system.

scientific article published in January 2015

Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia.

scientific article published on 4 August 2017

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

scientific article

Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.

scientific article published on 22 July 2013

Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1)

scientific article published on 8 March 2017

Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+ /NADH ratios

scientific article published on 02 January 2020

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies

scientific article published on 16 November 2018

Potent antimycobacterial activity of the pyridoxal isonicotinoyl hydrazone analog 2-pyridylcarboxaldehyde isonicotinoyl hydrazone: a lipophilic transport vehicle for isonicotinic acid hydrazide.

scientific article

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

scientific article published in April 2015

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

scientific article published on February 2016

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

scientific article published on 5 May 2016

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

scientific article published on 19 February 2016

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

scientific article published on 07 April 2019

The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia.

scientific article published on 09 December 2009

The metastasis suppressor, NDRG1, attenuates oncogenic TGF-β and NF-κB signaling to enhance membrane E-cadherin expression in pancreatic cancer cells

scientific article published on 01 July 2019

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

scientific article published on 3 November 2015

The potential of the novel NAD+ supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich's ataxia

scientific article published on 04 February 2020

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

scientific article published in April 2015

The role of NDRG1 in the pathology and potential treatment of human cancers

scientific article published on 08 June 2013

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

scientific article published on 5 January 2018

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

scientific article published in 2020

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