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List of works by Long-Sheng Song

A comparison of murine smooth muscle cells generated from embryonic versus induced pluripotent stem cells.

scientific article

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

scientific article

Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo

scientific article published on 29 March 2017

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

scientific article

AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytes

scientific article

CaMKII determines mitochondrial stress responses in heart

scientific journal article

Calcium biology of the transverse tubules in heart

scientific article

Calcium flickers steer cell migration.

scientific article

Calmodulin Regulation of Excitation-Contraction Coupling in Cardiac Myocytes

Calmodulin kinase II inhibition protects against structural heart disease

scientific article published on 27 March 2005

Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure

scientific article

Calsequestrin Accumulation in Rough Endoplasmic Reticulum Promotes Perinuclear Ca2+ Release ⬇️

scientific article published on March 28, 2012

Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction

scientific article published on 01 July 1999

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release

scientific article published on 10 July 2011

Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II.

scientific article

Ca²⁺ microdomains organized by junctophilins

scientific article published on 25 January 2015

Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes

scientific article published on 30 May 2016

Critical Roles of STAT3 in β-Adrenergic Functions in the Heart

scientific article

Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy by Regulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-Activated Protein Kinase Pathways.

scientific article published in June 2017

Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes.

scientific article

E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator

scientific article published in Science

Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.

scientific article published in January 2005

Effects of propofol on ischemia-induced ventricular arrhythmias and mitochondrial ATP-sensitive potassium channels ⬇️

scientific article published on September 17, 2012

Emerging mechanisms of T-tubule remodelling in heart failure ⬇️

scientific article published on 07 February 2013

FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice

scientific article published on 3 March 2011

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

scientific article (publication date: 27 June 2003)

Genetic Inhibition of Na + -Ca 2+ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate ⬇️

scientific article published on November 27, 2012

Ginsenoside Rg1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of p38.

scientific article published on July 2016

I(f) and SR Ca(2+) release both contribute to pacemaker activity in canine sinoatrial node cells

scientific article

In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts

scientific article published on 6 May 2015

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

scientific article published on 7 July 2015

Joiner et al. reply.

scientific article published in September 2014

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

scientific article published on 27 May 2013

LRRC10 (Leucine-Rich Repeat Containing Protein 10) and REEP5 (Receptor Accessory Protein 5) as Novel Regulators of Cardiac Excitation-Contraction Coupling Structure and Function

scientific article published on 3 February 2018

Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.

scientific article published on 15 July 2009

MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.

scientific article

MicroRNA: a toolkit fine-tuning the dyadic "fuzzy space"?

scientific article published on September 2012

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

scientific article published on 11 February 2014

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

scientific article published on 10 June 2015

Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia

scientific article published on 13 September 2016

Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.

scientific article published on 08 July 2015

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy.

scientific article published on 20 December 2015

Orphaned ryanodine receptors in the failing heart.

scholarly article

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.

scientific article

Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

scientific article

PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes

scientific article (publication date: 2011)

Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy.

scientific article published on 28 July 2005

Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes.

scientific article published in December 1997

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice

scientific article published on 15 July 2013

Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes.

scientific article

Propofol and arrhythmias: two sides of the coin

scientific article

Regional distribution of T-tubule density in left and right atria in dogs

scientific article published on 23 September 2016

Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure

scientific article published on 3 March 2015

Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia.

scientific article published in April 2018

Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads.

scientific article published on 16 December 2013

Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model

scientific article

Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.

scientific article published on 27 December 2011

Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.

scientific article

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

scientific journal article

Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis

scientific article published on 19 January 2018

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

scientific article

T-tubule remodeling during transition from hypertrophy to heart failure.

scientific article published on 24 June 2010

Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models

scientific article published on 28 August 2018

Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes

scientific article published on December 1998

The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.

scientific article

The mitochondrial uniporter controls fight or flight heart rate increases.

scientific article

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

scientific article

Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity

scientific article published on 4 January 2018

Twenty years of calcium imaging: cell physiology to dye for.

scientific article

β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.

scientific article

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