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List of works by Peter Duewell

A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice

scientific article published on 31 May 2016

An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma.

scientific article

Assessment and quantification of crystal-induced lysosomal damage.

scientific article published in January 2013

Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.

scientific article published on May 2013

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

scientific article published on 04 May 2010

Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8(+) T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model.

scientific article published on 3 January 2014

Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies.

scientific article

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

scientific article published on 15 November 2018

ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.

scientific article

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

scientific article published on 06 November 2019

Immunotherapy in Tumors.

scientific article

Induction of immunogenic cell death by targeting RIG-I-like helicases in pancreatic cancer.

scientific article published on October 2014

Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant

scientific article published on 07 March 2014

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

scientific article published on 28 November 2018

NLRP3 inflammasome activation in inflammaging

scientific article published on 26 September 2018

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article (publication date: 29 April 2010)

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

scientific article published on 8 March 2018

P10. Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8+ T cell and B cell responses but improves clinical efficacy in a murine pancreatic carcinoma model.

scientific article published on 12 March 2014

P17. RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells

scientific article published on 12 March 2014

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

scientific article published on 30 August 2018

Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer

scientific article published on 8 March 2016

Proapoptotic and antiapoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells toward gemcitabine and T-cell-mediated cytotoxicity

scientific article

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors

scientific article published on 11 October 2012

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

scientific article published on 18 November 2019

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells

scientific article

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells.

scientific article

Strategies to relieve immunosuppression in pancreatic cancer.

scientific article published on January 2015

Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

scientific article published on 24 May 2020

Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.

scientific article published on 14 April 2015

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer

scientific article published on 21 January 2013

Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages

scientific article published in January 2017

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

scientific article published in January 2018

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