List of works - Frank Bosmans

A disease mutation reveals a role for NaV1.9 in acute itch

scientific article published on 05 November 2018

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

scientific article

A first exploration of the venom of the Buthus occitanus scorpion found in southern France.

scientific article published on 10 January 2014

A painful tale about synthetic scorpion toxins

scientific article published on 10 March 2016

A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.

scientific article

Adaptive evolution of scorpion sodium channel toxins.

scientific article published in February 2004

Animal peptides targeting voltage-activated sodium channels.

scientific article published on January 2008

Animal toxins can alter the function of Nav1.8 and Nav1.9.

scientific article

Animal toxins influence voltage-gated sodium channel function.

scientific article published on January 2014

Binary architecture of the Nav1.2-β2 signaling complex

scientific article published on 19 February 2016

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.

scientific article

Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias

scientific article published on 16 September 2020

BjalphaIT: a novel scorpion alpha-toxin selective for insects--unique pharmacological tool

scientific article published in March 2005

Crystallographic insights into sodium-channel modulation by the β4 subunit

scientific article

Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity.

scientific article published on 14 October 2006

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

scientific article

From foe to friend: using animal toxins to investigate ion channel function

scientific article

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana

scientific article

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

scientific article

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

scientific article published on 13 April 2003

Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri

scientific article

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2

scientific article

Interactions between lipids and voltage sensor paddles detected with tarantula toxins ⬇️

scientific article

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

scientific article published on 25 October 2016

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity

scientific article

Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1.

scientific article published on 27 January 2005

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

scientific article

NaV1.1 inhibition can reduce visceral hypersensitivity

scientific article published on 07 June 2018

Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents

scientific article (publication date: 16 May 2014)

New rule(r)s for FRET.

scientific article published on December 2013

Palmitoylation influences the function and pharmacology of sodium channels.

scientific article published on 28 November 2011

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

scientific article

Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch.

scientific article published in May 2005

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

scientific article published on 12 June 2017

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.

scientific article published on 5 December 2006

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

scientific journal article

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

scientific article published on 4 March 2015

Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves

scientific article published on 27 April 2017

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

scientific article

Spider toxin inhibits gating pore currents underlying periodic paralysis.

scientific article published on 10 April 2018

Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.

scientific article published on 22 September 2005

Structural basis of α-scorpion toxin action on Nav channels

scientific article

Targeting voltage sensors in sodium channels with spider toxins.

scientific article

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

scientific article published on 17 June 2015

The hitchhiker's guide to the voltage-gated sodium channel galaxy

scientific article

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

scientific article

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

scientific article

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension

scientific article published on 03 August 2018

The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins.

scientific article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating.

scientific article published on 29 November 2017

List of works by Frank Bosmans

A disease mutation reveals a role for NaV1.9 in acute itch

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

A first exploration of the venom of the Buthus occitanus scorpion found in southern France.

A painful tale about synthetic scorpion toxins

A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.

Adaptive evolution of scorpion sodium channel toxins.

Animal peptides targeting voltage-activated sodium channels.

Animal toxins can alter the function of Nav1.8 and Nav1.9.

Animal toxins influence voltage-gated sodium channel function.

Binary architecture of the Nav1.2-β2 signaling complex

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.

Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias

BjalphaIT: a novel scorpion alpha-toxin selective for insects--unique pharmacological tool

Crystallographic insights into sodium-channel modulation by the β4 subunit

Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity.

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

From foe to friend: using animal toxins to investigate ion channel function

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2

Interactions between lipids and voltage sensor paddles detected with tarantula toxins ⬇️

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity

Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1.

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

NaV1.1 inhibition can reduce visceral hypersensitivity

Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents

New rule(r)s for FRET.

Palmitoylation influences the function and pharmacology of sodium channels.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch.

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Spider toxin inhibits gating pore currents underlying periodic paralysis.

Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.

Structural basis of α-scorpion toxin action on Nav channels

Targeting voltage sensors in sodium channels with spider toxins.

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

The hitchhiker's guide to the voltage-gated sodium channel galaxy

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension

The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating.