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List of works by Jan Voorberg

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

scholarly article by Maaike Rijkers et al published October 2018 in Haematologica

Absence of mutations at the activated protein C cleavage sites of factor VIII in 125 patients with venous thrombosis

scientific article published on 01 March 1996

Acquired TTP: ADAMTS13 meets the immune system

scientific article

Acquired thrombotic thrombocytopenic purpura. Development of an autoimmune response

scientific article

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis

scientific article published on 8 October 2013

Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.

scientific article

An open conformation of ADAMTS13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura.

scientific article published on 9 December 2017

Analysis of factor VIII inhibitors in a haemophilia A patient with an Arg593-->Cys mutation using phage display.

scientific article

Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation

scientific article published on 30 June 2016

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease

article

Angiogenic characteristics of blood outgrowth endothelial cells from patients with von Willebrand disease

scientific article published on 21 September 2015

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

scientific article published on 20 September 2018

Antibodies against recombinant alpha-galactosidase A in Fabry disease: Subclass analysis and impact on response to treatment

scientific article published on 17 November 2018

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

scientific article published on 01 June 1994

Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry.

scientific article published on September 1995

Biogenesis and exocytosis of Weibel-Palade bodies.

scientific article

Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation ⬇️

scientific article published on December 29, 2011

CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides.

scientific article

Characterization of three different flavodoxins from Azotobacter vinelandii.

scientific article

Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells.

scientific article published on 12 October 2017

Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus

scientific article published on 25 February 2015

Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions

scientific article published on July 2008

Dangerous liaisons: how the immune system deals with factor VIII ⬇️

scientific article published on January 1, 2013

Decrypting C2 inhibitors

scientific article published on 01 April 2014

Desmopressin in moderate hemophilia A patients: a treatment worth considering.

scientific article published on 5 January 2018

Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease

scientific article published on 01 December 2006

Disappearing acts of ADAMTS13

scientific article

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.

scientific article published on 19 April 2018

Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells.

scientific article published on 20 October 2005

Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice

scientific article

Effect of laminar shear stress on the distribution of Weibel-Palade bodies in endothelial cells

scientific article published on 07 September 2012

Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies

scientific article published on 19 September 2007

Emerging Concepts in Immune Thrombocytopenia.

scientific article

Enhanced thrombin sensitivity of a factor VIII-heparin cofactor II hybrid

scientific article published on 01 August 1996

Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells

scientific article published on 21 November 2016

Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.

scientific article published on 28 July 2011

Establishment of outgrowth endothelial cells from peripheral blood

scientific article published on 23 August 2012

Evaluation of the haemostatic potential of factor VIII‐heparin cofactor II hybrid proteins in a mouse model ⬇️

scientific article published on November 1, 2003

Evaluation of the role of the GPIb-IX-V receptor complex in development of the platelet storage lesion.

scientific article published on 17 May 2016

Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura

scientific article

Factor V Arg506-->Gln mutation in patients with antiphospholipid antibodies

scientific article published on 01 August 1996

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

scientific article published on 5 September 2013

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies

scientific article published on 22 September 2011

Factor VIII inhibitor in a patient with mild haemophilia A and an Asn618-->Ser mutation responsive to immune tolerance induction and cyclophosphamide.

scientific article published in April 2002

Factor VIII-specific B cell responses in haemophilia A patients with inhibitors.

scientific article published on May 2010

Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking

scientific article published on 5 January 2017

Functional architecture of Weibel-Palade bodies

scientific article

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.

scientific article

HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg593 to Cys mutation.

scientific article

Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura ⬇️

scientific article published on July 1, 2011

Hunting down factor VIII in the immunopeptidome

scientific article

Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13.

scientific article

Identification of glycans on plasma-derived ADAMTS13.

scientific article published on 29 August 2016

Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro.

scientific article published in September 2003

Improving on nature: redesigning ADAMTS13.

scientific article

Individual with subclinical atherosclerosis have impaired proliferation of blood outgrowth endothelial cells, which can be restored by statin therapy

scientific article

Inhibitors in Nonsevere Hemophilia A: What Is Known and Searching for the Unknown

scientific article published on 13 February 2018

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

scientific article published on 5 January 2018

Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A.

scientific article published in February 2000

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles

scientific article published on 16 December 2008

Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A.

scientific article published on September 1996

Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease

scientific article published on 19 May 2011

KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

scientific article published on 02 February 2006

Limited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII.

scientific article published on 14 November 2013

Long-term expression of human coagulation factor VIII in a tolerant mouse model using the φC31 integrase system.

scientific article published on 26 January 2012

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

scientific article published on 22 March 2018

Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry.

scientific article published on 8 September 2017

Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura.

scientific article published on 8 August 2006

Patient‐derived monoclonal antibodies directed towards beta2 glycoprotein‐1 display lupus anticoagulant activity ⬇️

scientific article published on April 1, 2011

Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies.

scientific article

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

scientific article

Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells

scientific article

Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.

scientific article

Proteomic screen identifies IGFBP7 as a novel component of endothelial cell-specific Weibel-Palade bodies

scientific article published on 12 April 2012

Rational design of small molecules targeting the C2 domain of coagulation factor VIII.

scientific article published on 13 November 2013

Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies.

scientific article published on 3 April 2003

Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

scientific article published on 26 October 2011

STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a

scientific article published on 3 April 2014

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

scientific article published in 2022

Slipping out the Weibel-Palade body

scientific article published on 01 June 2008

Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells.

scientific article

Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells

scientific article published on 01 June 2001

Small GTP-binding proteins in human endothelial cells

scientific article

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.

scientific article

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

scientific article published on 31 March 2009

Storage and secretion of naturally occurring von Willebrand factor A domain variants

scientific article published on 08 August 2014

Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells

scientific article

T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site.

scientific article

The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells

The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies.

scientific article

To serve and protect: The modulatory role of von Willebrand factor on factor VIII immunogenicity

scientific article

Up or out: polarity of VWF release.

scientific article

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

scientific article published in October 2011

VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

scientific article

Variation in baseline factor VIII concentration in a retrospective cohort of mild/moderate hemophilia A patients carrying identical F8 mutations

scientific article published on 10 December 2016

Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line.

scientific article published on May 2003

von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.

scientific article

von Willebrand factor remodeling during exocytosis from vascular endothelial cells

scientific article published in November 2013

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