List of works - Dmitri R Davydov

A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).

scientific article

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

scientific article published on 01 December 2008

Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.

scientific article published on 8 June 2007

Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.

scientific article

Aluminum‐substituted heme domain of P450BM‐3 (BMP): Introducing a heme‐derived fluorescent probe for studies of substrate binding and protein–protein interactions in cytochromes P450 ⬇️

scientific article published on January 1, 2013

CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450.

scientific article published on 25 January 2013

Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. II. Kinetic parameters of reductase and monooxygenase reactions

scientific article published on 01 November 1992

Compressibility of the heme pocket of substrate analogue complexes of cytochrome P-450cam-CO. The effect of hydrostatic pressure on the Soret band

scientific article published in October 1995

Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations

scientific article

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

scientific article published in December 2003

Constrained water access to the active site of cytochrome P450 from the piezophilic bacterium Photobacterium profundum

scientific article published on December 2010

Cytochrome C (Fe2+) as a competitive inhibitor of NADPH-dependent reduction of cytochrome P450 LM2: locating protein-protein interaction sites in microsomal electron carriers

scientific article published on September 1, 1992

Cytochrome P450 from Photobacterium profundum SS9, a piezophilic bacterium, exhibits a tightened control of water access to the active site

scientific article published on 23 November 2010

Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4

scientific article published on 01 January 1999

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.

scientific article published on 11 January 2008

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

scientific article published on 21 December 2009

High pressure induced inactivation of ferrous cytochrome P-450 LM2 (IIB4) CO complex: evidence for the presence of two conformers in the oligomer

scientific article published on 01 October 1992

High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

scientific article published in July 1995

Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

scientific article

Interactions of cytochrome P450 2B4 with NADPH-cytochrome P450 reductase studied by fluorescent probe

scientific article published on 01 January 1996

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

scientific article published on October 2005

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.

scientific article published on 7 December 2007

Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

scientific article published on January 2007

Mechanisms that regulate production of reactive oxygen species by cytochrome P450.

scientific article published in September 2004

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.

scientific article published on 12 March 2011

Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.

scientific article

Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)

scientific article

Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

scientific article published on July 2013

Random distribution of NADPH-specific flavoprotein and cytochrome P-450 in liver microsomes

scientific article published on 01 December 1982

Reduction and catalytic properties of cytochrome P-450 LM2 in reconstituted system containing monomeric carriers

scientific article published on 01 September 1987

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

scientific article published on 3 May 2005

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

scientific article published on 12 January 2007

Stabilization of P450 2B4 by its association with P450 1A2 revealed by high-pressure spectroscopy.

scientific article published in October 2000

The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes

scientific article

Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450

scientific article published on 26 April 2006

List of works by Dmitri R Davydov

A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.

Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.

Aluminum‐substituted heme domain of P450BM‐3 (BMP): Introducing a heme‐derived fluorescent probe for studies of substrate binding and protein–protein interactions in cytochromes P450 ⬇️

CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450.

Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. II. Kinetic parameters of reductase and monooxygenase reactions

Compressibility of the heme pocket of substrate analogue complexes of cytochrome P-450cam-CO. The effect of hydrostatic pressure on the Soret band

Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

Constrained water access to the active site of cytochrome P450 from the piezophilic bacterium Photobacterium profundum

Cytochrome C (Fe2+) as a competitive inhibitor of NADPH-dependent reduction of cytochrome P450 LM2: locating protein-protein interaction sites in microsomal electron carriers

Cytochrome P450 from Photobacterium profundum SS9, a piezophilic bacterium, exhibits a tightened control of water access to the active site

Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

High pressure induced inactivation of ferrous cytochrome P-450 LM2 (IIB4) CO complex: evidence for the presence of two conformers in the oligomer

High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

Interactions of cytochrome P450 2B4 with NADPH-cytochrome P450 reductase studied by fluorescent probe

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.

Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

Mechanisms that regulate production of reactive oxygen species by cytochrome P450.

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.

Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.

Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)

Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

Random distribution of NADPH-specific flavoprotein and cytochrome P-450 in liver microsomes

Reduction and catalytic properties of cytochrome P-450 LM2 in reconstituted system containing monomeric carriers

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

Stabilization of P450 2B4 by its association with P450 1A2 revealed by high-pressure spectroscopy.

The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes

Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450