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List of works by Evripidis Gavathiotis

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival ⬇️

scientific article published on September 21, 2012

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

scientific article published on 02 March 2020

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

scientific article

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

scientific article published on 21 September 2021

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

scientific article published on 01 October 2016

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

scientific article published on 12 July 2016

An interconnected hierarchical model of cell death regulation by the BCL-2 family

scientific article

BAX activation is initiated at a novel interaction site

scientific article

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

scientific article

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

scientific article published on November 2010

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

scientific article published on 01 February 2019

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

scientific article published on 22 April 2021

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

scientific article published on 13 January 2021

Chemical genetics: Unraveling cell death mysteries.

scientific article published on June 2016

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

scientific article

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study ⬇️

scientific article published on December 19, 2001

Correcting mitochondrial fusion by manipulating mitofusin conformations

scientific article

Current Insights of BRAF Inhibitors in Cancer.

scientific article published on 20 February 2018

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

scientific article published on 2 May 2017

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.

scientific article

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

scientific article

Direct and selective small-molecule activation of proapoptotic BAX

scientific article published on 27 May 2012

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

scientific article published on 3 January 2014

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

scientific article

Editorial overview: Chemical genetics and epigenetics.

scientific article published on 8 August 2017

Eltrombopag directly inhibits BAX and prevents cell death

scientific article published on 18 February 2021

Erratum: Corrigendum: Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

scholarly article published in Nature Chemical Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

scientific article

ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation.

scientific article published on 20 April 2018

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

scientific article

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

scientific article published on 12 February 2015

Inhibitors of BRAF dimers using an allosteric site

scientific article published on 01 September 2020

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

scientific article published in April 2018

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3

scientific article published on July 2013

New perspectives for targeting RAF kinase in human cancer.

scientific article

Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

scientific article published on 11 January 2019

Pharmacological inhibition of the transcription factor PU.1 in leukemia

scientific article published on 30 October 2017

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

scientific article

Progress in targeting the BCL-2 family of proteins.

scientific article

Pulling the BAX trigger for tumor cell death.

scientific article published on 12 January 2018

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

scholarly article by Evripidis Gavathiotis et al published 17 December 2001 in Angewandte Chemie International Edition

Self-regulation of BAX-induced cell death.

scientific article published on 10 September 2016

Small-molecule allosteric inhibitors of BAX

scientific article published on 04 February 2019

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

scientific article

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations

scientific article

Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.

scientific article

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

scientific article published on 02 May 2019

The structure of FADD and its mode of interaction with procaspase-8

scientific article published on 01 June 2006

Tracking BAX once its trigger is pulled ⬇️

scientific article published on March 15, 2011

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